The normal distribution of corneal eccentricity and its determinants in two rural areas of north and south of Iran

PurposeThe aim of this study was to determine the distribution of corneal eccentricity (E-value) in a normal population and to examine related factors.
MethodsIn this cross-sectional study, two villages were selected in Iran using multistage cluster sampling. Selected persons were invited to have a comprehensive eye examination. Examinations in each village were performed at a specific location under standard conditions. After testing for vision and refraction and conducting the slit-lamp exam, E-value was measured with Pentacam.
ResultsOf the 3851 selected individuals, 3314 participated in the study. After applying the exclusion criteria, data from 2610 subjects was used in the analysis for this report. Mean E-value was 0.53 [95% confidence interval (CI): 0.52 to 0.54]. E-value was not significantly different between males and females. Mean E-value reduced with age from 0.60 in subjects aged 6–20 years to 0.47 in subjects older than 70 years. The hyperopic group of participants had significantly lower E-value than myopic and emmetropic ones (P ConclusionsThe results of this study showed that the cornea in normal populations is prolate, and the degree of prolateness varies by age, such that older age is associated with a less prolate cornea. This study showed that factors such as age and refractive errors and anterior chamber indices influence the E-value.