Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis
Author(s):
Zheng Zhang , Xing Tong , Yu-Lu Wei , Lin Zhao , Jia-Ying Xu , Li-Qiang Qin
Article Type:
Review Article (دارای رتبه معتبر)
Abstract:
Background
Pycnogenol exhibits many biological activities, including control of blood pressure (BP). However, the reported results are inconsistent because of varied characteristics of participants and quality of studies. Thus, a meta-analysis was conducted to examine the effect of Pycnogenol supplementation on BP.Methods
This literature search of PubMed, the Web of Science and the Cochrane library was performed in May 2016 to identify eligible studies. Reference lists of the retrieved articles were also reviewed. Either a fixed-effects or, in the presence of heterogeneity, a random-effects model was used to calculate the effect of combined treatment.Results
We identified nine trials involving 549 participants who received Pycnogenol supplementation ranging from 150 mg/d to 200 mg/d. Compared with the control, the pooled estimate of change in systolic and diastolic BPs were -3.22 mmHg (95% CI: -6.20, -0.24) and -3.11 mmHg (95% CI: -4.60, -1.62), respectively. Subgroup analyses showed higher BP reduction among hypertensive participants or those who received intervention for more than 12 wk. However, this significant reduction was not observed in well-designed trials.Conclusion
This meta-analysis with nine trials provides better evidence that Pycnogenol exerts beneficial effects on BP.Keywords:
Language:
English
Published:
Iranian Journal of Public Health, Volume:47 Issue: 6, Jun 2018
Pages:
779 to 787
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