The Effects of Metformin on Thyroid Function among Patients with Subclinical Hypothyroidism and Coexisting Metabolic Syndrome
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
The interference of metformin with thyroid function has been recently reported in several studies. In the present research, we assessed the effect of metformin on thyroid function tests in patients with subclinical hypothyroidism associated with metabolic syndrome.
Method
In a double-blind clinical trial, 60 patients were selected among who referred to outpatient endocrine clinics and met the inclusion and exclusion criteria were considered for the study. Inclusion criteria were the presence of metabolic syndrome and subclinical hypothyroidism (2.5
Results
A total of 44 patients fully participated for the whole study period. The mean age was 44±14 years and 15 patients (34.1%) were male. The mean TSH and FT4 levels before and after intervention were 5.8±2.15, 4.8±2.7 and 1.10±0.19, 1.14±0.26, respectively. The positive TPO-ab was seen among 18 (40.9%) patients. TSH (4.12±2.07, p=0.013) and FT4 (1.18±0.23, p=0.007) levels were decreased and increased, respectively, compared to the placebo group. Furthermore, a reduction in metabolic element was observed.
Conclusion
Our data showed that metformin reduced the TSH level in subclinical hypothyroid patients, especially in patients with TSH baseline level higher than 5mIU/l and TPO-ab positive patients.
Language:
English
Published:
Pharmaceutical Sciences, Volume:24 Issue: 2, Jun 2018
Pages:
118 to 123
magiran.com/p1847929  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!