Novel Effects of Rosa damascena Extract on Patients with Neurocognitive Disorder and Depression: A Clinical Trial Study
Author(s):
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Dementia as a major cognitive neurological disorder is defned as impairment in one or more cognitive territories compared with the former level of performance. This disorder disrupts patients independence, and the patient would need others aid in order of doing daily and complex activities. The aim of this study was to evaluate the effcacy of Rosa damascena extract in the improvement of cognitive function in patients with dementia.Methods
This study is a randomized double-blind, placebo-controlled clinical trial on 40 patients older than 55 years with dementia referred to Specialized Elderly Patients Clinic in 20152016. Patients were divided randomly into two groups (control and intervention). The intervention group used donepezil and R. damascena capsules, and in control group, placebo capsule instead of R. damascena added on donepezil. Four test was flled three times at the study initiation, after month one and also after month three: MiniMental State Examination (MMSE) and Addenbrookes Cognitive Examination Revised (ACE-R) were used for cognition evaluation, for depression assessment, Geriatric Depression Scale was administered, and checklist of memory and behavioral disorders were flled.Results
The results showed add-on donepezil and R. damascena versus placebo improved cognitive impairment based on MMSE with P = 0.002, ACE-R with total P = 0.001, depression (P = 0.012), behavioral disorders (P Conclusions
The R. damascena extract affected cognitive impairment of dementia patients signifcantly and also have signifcant effects on improving depression and behavioral problems.Keywords:
Language:
English
Published:
International Journal of Preventive Medicine, Volume:9 Issue: 6, Jun 2018
Page:
4
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