Regression of giant olfactory groove meningioma and complete visual acuity recovery after discontinuation of cyproterone acetate

To report on the medical management of meningioma with compression of the optic chiasm associated with the use of cyproterone acetate (CA).
Case Report: A 65-year-old woman who was being treated with CA presented with a recent decrease in visual function, leading to discovery of a giant olfactory groove meningioma with compression of the optic chiasm. CA was discontinued immediately, and her visual function improved dramatically. At 13 months, in addition to a significant improvement in visual and neurocognitive symptoms, the tumor volume was reduced by 50%.
In meningiomas associated with CA, treatment cessation may result in prompt improvement in symptoms and a reduction in tumor volume, even if the tumor is large and causing neurologic impairments.