The Antiapoptotic Effect of Curcumin in the Fibroblast of the Cochlea in an Ototoxic Rat Model

This study aimed to show the potency of curcumin as an antiapoptotic agent that decreases the apoptotic index in the cochlea lateral wall in ototoxic rat models.

A total of 24 Rattus norvegicus were divided into eight groups: Group 1 (control group), Group 2 (gentamicin ()), Group 3 (gentamicin curcumin 20 mg/day), Group 4 (gentamicin curcumin 40 mg/day), Group 5 (gentamicin curcumin 20 mg/day for 7 days), Group 6 (gentamicin curcumin 40 mg/day for 7 days), Group 7 (curcumin 20 mg/day for 3 days gentamicin), and Group 8 (curcumin 40 mg/day for 3 days gentamicin). After the division, the rats were terminated in order to measure the apoptotic index using a terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling (TUNEL) assay in the fibroblasts of the cochlea lateral walls. The data were analyzed using analysis of variance (ANOVA), and P

Administration of gentamicin showed significant differences (P

This study concluded that the apoptotic index can be decreased by curcumin and has a preventive benefit toward ototoxic rat models. The administration of curcumin depended on the dose and duration.