Serum levels of serotonin as a biomarker of newly diagnosed fibromyalgia in women: Its relation to the platelet indices

Tis study aimed to assess the serum serotonin levels in the newly diagnosed fbromyalgia (FM) and to relate these levels to the presenting signs and symptoms.
Tis case–control study included 35 healthy women (Group I) served as controls and 130 women with newly diagnosed FM (Group II). Te diagnosis of FM was confrmed by the diagnostic criteria of the American College of Rheumatology?10. Te assessment of pain using a revised fbromyalgia impact questionnaire and tender points scoring, blood platelet indices, and serum serotonin levels were determined.
Group II patients had signifcantly (P Newly diagnosed FM women have signifcantly low?serum serotonin levels, which does not correlate with a signifcant increment of the platelet activity expressed as increase MPV and platelet width distribution percentage. Terefore, this study highlighted that the correction of serum serotonin level by medicines could help the patients.