Mycosis fungoides with an unusual clinicopathological presentation

It is a challenging task to diagnose mycosis fungoides (MF), a type of primary cutaneous lymphoma, in the early stages of its development, due to the unspecific presentations associated with the disease. Histopathology and immunohistochemistry conduce to a more definite diagnosis. Presence of atypical T-cells in epidermis and upper dermis is the most significant pathologic finding. Herein, we present an 80-year-old lady with unusual generalized lesions resembling prurigo nodularis for 3 years, who was finally diagnosed as a case of MF with eosinophilic infiltrations in her lesions and serum eosinophilia.