Effect of Swimming Exercise to Cardiac PGC-1 α and HIF-1 α Gene Expression in Mice
Article Type:
Research/Original Article (دارای رتبه معتبر)
Abstract:
Background
Hypoxia caused by exercise condition may alter PGC-1α and HIF-1α expression in cardiac cells. Both factors are transcriptional factors which play a role in conserving energy during metabolic process. However, there is less information about the effects of long term moderate intensity exercise such as swimming on PGC-1α and HIF-1α expression in cardiac cells.
Objectives
Aim of this study is to observe the effect of force swimming exercise on the expression PGC-1α and HIF-1α gene expression in cardiac muscle of mice.
Methods
Male BALBc mice were divided into two groups (n = 10): control (C) and swimming (ST). ST group was subjected to moderate intensity swimming for 4 weeks, 30 minutes/day for 5 days. Hearts of animal models were preserved for cardiac morphology study using HE staining, PGC-1α and HIF-1α mRNA expression study.
Results
We observed that cardiac PGC-1α expression in ST was significantly increased 1.5 fold compared with control group (0.64 vs 0.44; CI = 95%, -0.378 - 0.019; P = 0.035), but expression of HIF-1α was significantly decreased 0.4 times lower than control group (0.35 vs 0.52; CI = 95%, 0.27 - 0.31; P = 0,025).
Conclusions
Taken together, ST group increased the expression of PGC-1α but decreased the expression of HIF-1α in mice cardiac muscle in response to chronic hypoxia condition.Language:
English
Published:
Asian Journal of Sports Medicine, Volume:9 Issue: 4, Dec 2018
Page:
8
magiran.com/p1909166
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یکساله به مبلغ 1,390,000ريال میتوانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
- حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران میشود.
- پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانههای چاپی و دیجیتال را به کاربر نمیدهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required
Personal subscription
Subscribe magiran.com for 70 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!