Lack of Association between ctla - 4A49G Polymorphism and Vitiligo

Vitiligo is an acquired skin disorder that selectively destroys melanocytes in epidermis with an unknown etiology.

To investigate the exon 1 A49G polymorphism of cytotoxic T lymphocyte antigen-4 (ctla-4) gene in vitiligo patients.

The A49G polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method in 101 patients and 208 normal healthy age/ethnicity matched individuals.

The frequencies of heterozygote genotypes in patients and controls were found to be 42 (41. 6%) of 101 and 85 (40. 9%) of 208، respectively. The frequencies of homozygote A and G genotypes were 49 (48. 5%) and 10 (9. 9%) in 101 patients، whereas، these frequencies in 208 control individuals were 103 (49. 5%) and 20 (9. 6%)، respectively. There was no significant difference between the genotype (P = 0. 98) and allele (P = 0. 86) frequencies of A49G polymorphism in patients and normal healthy individuals.

Our results indicate that in contrast to several immune mediated disorders، there is no association between ctla-4 A49G gene polymorphism and vitiligo.