Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats

Abstract: To assess the effect of supplementation with vitamins A, E and C and ω-3 fatty acids on lipid peroxidation in strepto zotocin (STZ) induced diabetic rats. Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, dia betic with vitamin A, E as well as C supplementation and diabetic with ω-3 fatty acids supplementation. After four weeks of treat ment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart ho mogenate. In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P< 0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P< 0.05). A signifi cant decrease in heart MDA (P< 0.05) was observed in diabetic rats with ω-3 fatty acids supplementation. Supplementation of vitamin A, E and C and ω-3 fatty acids was found to decrease lipid peroxidation to some ex tent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes.