The Synthesis of Chlorophyll-a Skeleton Homologs Bearing Linear Six-Carbon Chain from Methyl Pheophorbide-a

The synthesis of chlorins bearing 6C-straight chain was accomplished from methyl pheophorbide-a. A series of chemical modifications were employed for the construction of active functional groups, such as bromine atom or aldehyde group, on the periphery of chlorins. These functionalized chlorins further reacted with the reagent containing straight carbon-chain by common chemical reactions to produce target compounds. The structures of all new chlorins were characterized by elemental analysis, IR, UV-Vis and 1H NMR spectra.