مجله تعالی بالینی
سال هفتم شماره 1 (پیاپی 14، تابستان 1396)

Benign prostatic hyperplasia (BPH) is a common disease in elderly men also cancer prostate is the most common malignancy in males of developed countries. Different Natural supplements have been found to effect the growth and proliferation of prostate cancer cells as evident in epidemiological, experimental and clinical studies. There is good evidence of protective effects of Natural supplements against prostate cancer are Explained.
In this paper, using online databases Iranmedex Pubmed, Medline, Google scholar, Scopous, Science direct, SID and Iranmedex on various aspects of medicinal plant stinging nettle was proposed up to 2016, with using keywords Benign prostatic hyperplasia, Urtica dioica, Saw palmetto, Pygeum africanum, Cucubita pepo, VitE and Vit B6 therapeutic effect and medicinal plant were studied.
Urtica dioica can be used as an effective drug for the management of Prostate disorders. Effects of U.dioica on benign induced by testosterone have been exhibited. Studies were conducted to assess the 5α-reductase inhibitory potential of this plant. Saw palmetto is an herbal product used in the treatment of symptoms related to benign Prostate disorders. Saw palmetto appears to have efficacy similar to that of medications like finasteride, but it is better tolerated and less expensive. Pumpkin seed extracts (Cucurbita pepo) contain oily substance composed of linolic acid sterols, seleneniume, magnesium and carotinoid that they have mechanism of action is thought to be antiandrogenic and antiphlogistic. Furthermore, many vitamins and chemicals, including vitaminE, vitaminB6 and Zinc have shown their anticancer activities as anti-oxidants. The use of medicinal herbs with BPH therapeutic properties can be used as a substitute or complementary of the chemical drugs that are effective in the treatment of prostate disorders.

Alzheimer's disease is one of the most common and common causes of dementia and a chronic, complex, and progressive neurological disorder. As family caregiver’s play an all-encompassing role in Alzheimer's elderly care, resilient learning gives them the opportunity to better understand and respond appropriately in challenging situations. Due to the importance of the subject and the existence of few studies in this field, the present study was carried out. This study is a overview study that focuses on the effect of resilient interventions on the family mental health of elderly people with Alzheimer's disease from 1995 to the end of 2016. Using keyword search in the title or abstract of the articles in the Magiran, SID, Medlib, Iranmedex databases for Farsi language studies and full-text articles in English at Produce Elsevier, Ovid, Pubmed, Science Direct sites using the following keywords were searched in the title of the article. Persian words including mental health, family caregivers, Alzheimer's disease, and resilient. These keywords in English include mental health, Family caregivers, Alzheimer’s disease, Resilient, with every single word aging, elder, ageing, older people elderly. After searching the available databases with proper keywords in both Farsi and English, 54 articles were obtained without time limit. Of these, 11 articles with the most relevance to our goals were selected and examined.
The results showed; the pressure from nursing care affects all physical, psychological, social, spiritual, and quality of life of family caregivers, and the pressure of care severely affects caregiver's mental health. Therefore, the need to intervene to reduce care pressure and provide resilience education to family caregivers improve the quality of care for the elderly with Alzheimers.

Aflatoxins are secondary metabolites of fungi, particularly Aspergillus flavus and Aspergillus parasiticus, that known to be the most dangerous mycotoxin. Among the more than 20 types of aflatoxin identified, four types of AFB1, AFB2, AFG1, AFG2, and two AFM1 and AFM2 (hydroxylated metabolites of AFB1 and AFB2 in animals and livestock products, respectively) have been identified as major contributors to pathogenicity. The carcinogenic role of these toxins recognized in liver target tissue.
Human exposure to mycotoxins occurs directly through the intake of contaminated agricultural products or indirectly through the consumption of products of animal origin prepared or obtained from animals that were fed with contaminated material. For detoxification and reduce threats to public health in the context of communities, and the economic damage caused by the aflatoxins in food products of animal and plants, different techniques (physical, chemical and biological) has been studied.
All of these methods, by modifying and destroying the toxin molecular structure, inhibit its transfer to the digestive system, and reduce the accessibility of toxins to the target tissue and eliminate it. The current review performed based on search in database Scopus, Elsevier, PubMed, Google scholar, Science Direct, Iranmedex, Magiran, SID and Irandoc of biological substance (bacteria, fungi, and algae) reviews the biological degradation of AFs by fungal microorganisms and converting it into non-toxic, or less toxic products, and providing appropriate solutions.

Territorial Agenda is a comprehensive process of planning to use advantage and talent of regional s for their growth and excellence. The development of the education system is one of the most effective action and guarantor of the sustainable development of societies. The implementation of the program on the development and innovation of medical education with the use of the capacity of the territorial planning program began in the country in 2015. The purpose of this study is to explain the Process of Establishment of Territorial Agenda and Development and Innovation in Medical Education in Iran. Using the keyword search about the title or abstract In the books compiled by the Ministry of Health and Education and in the databases like Magiran, SID, Medlib, Iranmedex, Google Scholar databases for Persian language studies and articles in English on the databases as PubMed, Science direct, Google Scholar between 2000 and 2016 The related articles were searched. The results showed that with the implementation of the program, targeted engagement between the universities of the region and the discourse of development and innovation in the academic atmosphere argos. Also, some packages such as the accreditation of institutions and educational centers, the upgrading of the testing system and the monitoring of development packages have made the results more tangible, and in some packages, such as the internationalization of medical education, virtual education and the promotion of professional ethics, good efforts have begun. And in moving packages to third-generation universities, accountable and advocacy education and promotion of educational infrastructure require better attention and planning. Considering the provision of sustainable resources and strengthening of educational infrastructure and faculty member's empowerment to achieve success in the program seems essential.

The lesson plan is one of the effective factors in the educational process. The main purpose of the lesson design is to facilitate learner learning. The present study aims to provide comprehensive information for use in medical science education. Using structured review criteria, this study examines the status of the design of the lesson plan and existing barriers. Using the keywords of the lesson plan, course design, teaching quality, effective teaching, curriculum, and medical science, the search for relevant articles was done in the databases.Databases are Science Direct, Irandoc, Google Scholar, Pudmed, SID, Scopus, Web of Science, Iranmedex, Magiran. Using the process of structured studies, using the process of structured studies, data was studied. In this study, the lesson plan was examined from various aspects.
The results showed that more than half of the lessons were in a moderate condition. Most of the weaknesses were related to minor goals and behavioral goals, assessment methods, teaching aid and how to use it. The presentation of the lesson plan in the classroom was not in desirable condition, most faculty members agreed to formulate the lesson plan before the start of the training, but the high workload, the constraints of facilities and training facilities, and the high number of students prevented the preparation of the course. The lesson plans were based on the curriculum, and the classroom teachers were guided by the lesson plan. Considering the necessity and importance of developing lesson plans in improving the quality of student's education, holding workshops on teachers can provide their knowledge and attitudes for the formulation and implementation of lesson plans.