International Journal Of Bio-Inorganic Hybrid Nanomaterials
Volume:7 Issue: 4, Winter 2018

An ionic liquid (IL) is a salt in the liquid state. In some contexts, the term has been restricted to salts whose melting point is below some arbitrary temperature, such as 100 °C. While ordinary liquids such as water and gasoline are predominantly made of electrically neutral molecules, ionic liquids are largely made of ions and short-lived ion pairs. These substances are variously called liquid electrolytes, ionic melts, ionic fluids, fused salts, liquid salts, or ionic glasses. They are known as "solvents of the future" as well as designer solvents. Very polar reactions can be carried out in these liquid in the absence of or with a controlled amount of water, and crystalline nanoparticles can be synthesized conveniently at ambient temperatures. The pronounced self-organization of the solvent is used in the synthesis of self-assembled, highly organized hybrid nanostructures with unparalleled quality. The extraordinary potential of ionic liquids in materials synthesis is described in this mini-review and a physicochemical explanation is given.

Nowadays carbon nanoparticles are applied on the island of single electron transistor and Nano-transistors. The basis of single electron devices (SEDs) is controllable single electron transfer between small conducting islands. Based on the important points in quantum mechanics, when a wave passes through several spatial regions with different boundaries, the wave function of the first region differs from the second and third wave functions. But the boundary conditions are similar in neighboring areas. The single-electron transistor as a nano-switch can control the current. In the single electron transistor, the velocity of current is influenced by the characteristics of materials such as conductivity. Therefore, the choice of two-dimensional graphene as a material with high conductivity can be increase speed in single-electron transistor. In this research, proposed a model of conductivity for single electron transistor with island as bilayer graphene. Also, the diagram of G-Vg is plotted and the number of key factors is checked.

The objective of this work was to characterize the cinnamon oil nanocapsule that contained alginate-chitosan as coating agents. In this work, cinamonn oil loaded chitosan nanoparticles (CS-alginate NP-cinamonn) are prepared by a two-step process including oil/water emulsion and ionic gelation. In this study, cinamon as a core material was nanoencapsulated with chitosan alginate at a ratio of 1:4 (core: wall). Fourier transform–infrared analysis revealed potential interactions among the constituents in the composite NPs. Scanning electron microscopic analysis showed that the particles were nearly spherical in shape with an average size of 100±20 nm. Encapsulation efficiency (%) of cinamonn in composite NPs showed considerable increase over ALG-CS NPs with tween 80. Results showed that emulation drop let size by this method were 40.2 ± 2.4 nm. TEM, it was indicated that particles size varies from the range of 50nm.

In this study, we reported a method to associate doxorubicin drug on folic acid functionalized SiO2/ZnO nanoparticles (NPs) in rod and spherical shapes. The clinical usage of the anticancer drug, doxorubicin (DOX), is limited by severe side effects and cell resistance. Targeted drug delivery by binding DOX to nanoparticles could overcome these limitations. The surface functionalization of the ZnO nanoparticles with silica and folic acid (FA) was confirmed by fourier transform infra-red spectra (FTIR) and Ultraviolet-visible spectroscopy. Drug is bound to the nanoparticle surface through electrostatic interactions. The potential of as-prepared anticancer drug loaded nanoparticles against the leukemia cancer cells, K562, was evaluated using the MTT assay and its anti tumor efficacy was clearly enhanced compared with free drug. Cell viability reached nearly 21% and 25% by drug loaded nanoparticles, whereas DOX itself led to only 40% viability at a concentration of 5 mg/ml. Moreover, the results showed that the rod- shaped particles have better cytotoxicity against leukemia cells than spherical particles because of their samller sizes.

A novel, simple, sensitive and effective method has been developed for preconcentration of the trace Pb (II) ions in aqueous Samples by CNT carboxyl which in order to improve the performance of extraction and preconcentration was used. Amounting of the ions density in solution was performed by the method of flame atomic absorption spectrometry. The effective parameters on extraction such as: effect of pH, the amount and eluent solvent, time of extraction and effect of other cation were optimized. Concentrate factor was found 30 and LOD method of limit of detection was found to 0.17µg.L-1. The relative standard deviation is 1.70% (RSD%).

Methanol (CH3OH) is a colorless liquid with a mild odor. The wide ranges of applications, toxicity and clinical implications of methanol have made necessary to develop reliable and high-performance methanol sensors. In this paper, WO3 thin films were deposited on SiO2/Si substrates by e-beam evaporation technique under normal and oblique angles and then post-annealed at 500 °C with a flow of oxygen for 4h to achieve a good crystallinity. The crystalline structure of the samples was confirmed by X-ray diffraction analysis while the physical adsorption isotherm was used to measure the porosity and effective surface area. These results reveal that the deposited sample under oblique angle shows more crystallinity, and porosity relative to the sample deposited at the normal angle. The response of the samples was tested with respect to methanol vapour with different concentrations in the temperature range of 140–260 °C. Reproducibility and stability of the samples were also investigated.

Dasatinib is a tyrosine kinase inhibitor (TKI) that is used to treat chronic myeloid leukemia and in the management of ulcerative colitis (UC) and to provide appropriate results in treatment. Dasatinib is significantly higher and faster than full cytogenetic and large molecular responses as compared to imatinib. In the recent study, using the NMR data, the frequency and thermochemical properties of the dasatinib structure and the attached form of this molecule have been explored and analyzed. In this paper, we will examine some computational studies on this subject using semi-empirical and Monte Carlo methods. The Hyperchem 8.0 and Gaussian 09 and Gauss View 5 were used to do methods for simulating molecular mechanics (MM+) and semi empirical. Quantum mechanics was calculated using B3LYP methods and the theoretical method of 6-31G. As a result, our findings indicate that the presence of Dasatinib can express the results of this molecule as anticancer agents.

To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Carbon nanotubes hold tremendous potential as an effective drug delivery system. The carboxylated multi-walled carbon nanotube was modified by p-amino acetanilide and 5-aminoisophthalic acid. The modified multi-walled carbon nanotube was used to adsorption and determines the amount of Buspirone drug in the human urine. The synthesized adsorbent was characterized using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX) and Thermogravimetric analysis (TGA). The developed method was utilized for determination of Buspirone drug in pharmaceutical and human urine samples by high performance liquid chromatography (HPLC).