Journal of Applied Organometallic Chemistry
Volume:1 Issue: 4, Oct 2021

Stemona alkaloids, are structurally complex and polycyclic alkaloids, obtained from a novel class of natural plants which are extracted, separated, and purified from Stemonaceae family. They are abundantly and more exclusively obtained from the renowned three classes namely: Stemona, Stichoneuron, and Croomia of monocotyledonous family Stemonaceae. They are structurally distinguished by the presence of a central pyrroloazepine core. By 2019, almost 215 Stemona alkaloids were isolated from nature. More than 80 members already discovered and many more are in pipeline likely to be isolated. Traditionally, their roots have been used for centuries in Chinese medicine for a variety of purposes including (but not limited to): treatment of bronchitis, tuberculosis, pertussis, as well as anti-parasitic agents. By rational comparing and contrasting, the multidimensional bioactivities of Stemona alkaloids specifically stemofoline-type derivatives are the most promising compounds representing many lead structures for further development of commercial agents used in pharmaceutical and chemical industries. Here, to this our total synthesis proposal, we vividly explained step by step the total synthesis procedure to get the Stemona alkaloid: Tuberostemonamide. This renowned Stemona alkaloid has potent pharmaceutical effects in the treatment of different neurodegenerative diseases and inflammatory conditions. For such fascinating future work and robust research scope, we interested to propose and work on a unique and effective total synthetic pathway for the Tuberostemonamide synthesis which can be used in synthetic organic lab. We believe our proposed synthetic process discussed here would be utilized efficiently and give highest possible yield (%).

We report a novel and eco-friendly methods approving the green synthesis of various Schiff’s bases by sonication, microwave irradiation, stirring and grinding methods using DHE and various aromatic aldehydes. We also offer the synthesis of aryl azo Schiff base by different ways and compare of the way of synthesize it. As a result, Sonication and microwave irradiation is the modest technique to synthesis aryl azo Schiff base. This technique is experimentally green, simple, greater yielding, clean, and with compact reaction times. Also, the synthesized compounds were tested for their antibacterial activity. The most admirable results were observed and it could be a potential starting point to develop innovative lead compounds fight against a panel of some human disease-causing pathogens bacteria

In the study, magnetic nanoparticles (MNPs) of the immobilized SbFx species on copper or nickel ferrite as CuFe2O4@SbFx and NiFe2O4@SbFx were synthesized. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), vibrating sample magnetometer (VSM), Brunauer-Emmett-Teller (BET) analysis and inductively coupled plasma optical emission spectroscopy (ICP-OES) were employed to characterize the prepared nanocatalysts. Catalytic activity of the naomaterials was more studied towards reduction and reductive acetylation of structurally diverse aromatic nitro compounds as well as acetylation of arylamines. Among the examined nanocatalyst systems, CuFe2O4@SbFx was used for reduction and reductive acetylation of aromatic nitro compounds, whereas, NiFe2O4@SbFx showed an activity towards acetlyaltion of arylamines. All reactions were carried out successfully in H2O as a green solvent under reflux conditions. After completion of the reactions, the examined nanocatalysts were easily removed from the reactions mixture by an external magnetic field. Their reusability was also examined for 5 consecutive cycles without the significant loss of the catalytic activity.

In this study, the application of the Diels-Alder cycloaddition reactions between methyl acrylate and cyclopentadiene has been studied using a silica-supported catalyst with various concentrations of Zn2+ ion (Silica@Zn+2) as Lewis acid catalyst without using the solvent. The effective role of silanol groups in increasing stereoselectivities of products was also studied.

A mild procedure for the diastereoselective Diels-Alder reaction of methyl acrylate and cyclopentadiene was performed using modified silica with different concentrations of metal ions as Lewis acid support. According to the results, among the tested metal ions, cadmium ion supported on the silica was the best diastereoselective catalyst in this reaction.

Today, nanotechnology is widely used in science and technology are growing rapidly. Nanoparticles synthesized with the help of plant extracts, due to the lack of use of external chemical agents, can have fewer side effects in medical applications.In this article, we synthesize silver nanoparticles (AgNPs) using the aqueous extract of Stachys lavandulifolia vahl. Plant extract in the synthesis of nanoparticles acts as a reducing and stabilizing agent and can also have fewer side effects in medical use and is environmentally friendly. The average size of nanosilver synthesized by this method is 68-69 nm and factors such as temperature, concentration, pH and time were investigated to optimize the reaction. Formation of silver nanoparticles was confirmed by UV–Vis spectroscopy, Energy Dispersive Spectroscopy (EDS) analysis , X-ray diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM)