فهرست مطالب
Research in Cardiovascular Medicine
Volume:2 Issue: 3, Apr-Jun 2013
- تاریخ انتشار: 1392/02/08
- تعداد عناوین: 8
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Pages 79-84BackgroundIntrapulmonary shunt as a result of atelectasis following cardiac surgeries is an important and common postoperative complication that results into pulmonary dysfunction typically lasting more than a week following surgery. Different methods have been provided to prevent these complications..ObjectivesIn order to prevent postoperative pulmonary complications, investigation of the effectiveness of continuous positive airway pressure (CPAP) and intermittent mandatory ventilation (IMV) during cardiopulmonary bypass (CPB) in patients undergoing coronary artery bypass grafting (CABG)..Materials And MethodsIn this prospective interventional study, 300 patients, candidate for elective CABG (On-Pump), were randomly allocated to 3 groups: A, B, C. Group A (CPAP) patients received CPAP at 10 cm H2O during CPB. Group B (IMV) patients received IMV with a tidal volume of 2 cc/kg and respiratory rate of 15/min and group C (control) patients did not receive any type of ventilation during CPB. Other procedures were similar between groups. Arterial blood samples were taken at 8 moments and arterial blood gas (ABG) analysis were compared between groups. Chest x-rays after CABG were also evaluated with respect to atelectasis..ResultsThe demographic data were similar in between three groups. Graft number, pump time and preoperative ABGs were not significantly different. Postoperative PaO2 were significantly higher in the CPAP and IMV groups and (A-a) DO2 were significantly lower in these two groups, compared to the control group..ConclusionsIn the present study, applying positive airway pressure methods (CPAP or IMV) during CPB was associated with better postoperative ABG measurements and (A-a) DO2..Keywords: Continuous Positive Airway Pressure, Coronary Artery Bypass Grafting, Cardiopulmonary Bypass
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Pages 85-89BackgroundAtrial fibrillation (AF) is the most common clinically significant cardiac arrhythmia. However, diagnosis of intraventricular dyssynchrony in patients with AF is difficult due to beat-to-beat variation. Additionally, evaluation of mechanical dyssynchrony in the traditional method is based on average of 5 to 10 beats, which is exhausting and time consuming. Single-beat evaluation of a beat with equal subsequent cardiac cycles has been proposed as an accurate method in patients with AF..ObjectivesWe proposed to evaluate intraventricular mechanical dyssynchrony by measuring time-to-peak systolic velocity between basolateral and basoseptal segments (septum to lateral wall delay) using Tissue Doppler Study (TDI) by two different methods..Materials And Methods31 patient (68 ± 10.3 years) with heart failure (EF < 35%) and AF rhythm, R-R cycle length more than 500 msec were evaluated. We found a target beat in which preceding R-R (R-R1) to pre-preceding R-R (R-R2) ratio was 1(RR1/RR2 = 1) then measured the intraventricular dyssynchrony in that cycle. Intraventricular dyssynchrony was also determined and averaged for 8 consecutive cardiac cycles. The values at RR1/RR2 = 1 were compared with the average of intraventricular dyssynchrony in eight cycles and the relationship between dyssynchrony were evaluated by paired T-test, linear Pearson correlation (r2), linear regression analysis..ResultsThe average of dyssynchrony in eight cycles showed a positive correlation with dyssynchrony in target beat RR1/RR2 = 1. Average of dyssynchrony in target beat was 46.77 msec, and average of 8 cycle was = 47.701, (P value = 0.776, Pearson linear correlation 0.769)..ConclusionsMeasurement of intraventricular dyssynchromy in basoseptal and basolateral segments in AF and heart failure patients in a single beat with RR1/RR2 = 1, were very similar to the average value of eight cardiac cycle..Keywords: Atrial Fibrillation, Heart Failure, Systole, Auditory neuropathy
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Pages 90-94BackgroundDespite technical refinements and improved long-term efficacy of the ablation procedure for treating AFL (AFL), the subsequent occurrence of AF (AF) following this procedure remains a significant clinical problem..ObjectivesTo determine long-term incidence and predictors of AF after catheter ablation of typical AFL..Material And MethodsBetween March 2005 and February 2010, a total of 84 consecutive patients who underwent catheter ablation of documented typical AFL were enrolled..ResultsCavotricuspid isthmus ablation was successful in terminating and preventing the re-induction of AFL in all 84 patients (100%). The mean follow-up duration for study was 26± 22 months. During the follow-up period, early AF occurred in 5% after successful catheter ablation of AFL and late AF in 11% of the patients. The clinical variables associated with the occurrence of AF after catheter ablation of AFL were female, a history of AF before AFL ablation, body mass index (BMI), and left atrial abnormality. However, logistic multivariate analysis demonstrated that only BMI was independently associated with the late AF (OR 1.36, 95% CI 1.11-1.70, P = 0.004)..ConclusionsCatheter ablation of flutter circuit will not prevent later manifestation of AF in 16% of the patients undergoing catheter ablation of the typical AFL. BMI was the only independent predictor of AF following catheter ablation of the typical AFL..Keywords: Atrial Flutter, Ablation, Atrial Fibrillation
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Pages 95-98BackgroundTIMI Frame Count (TFC) is one of the methods to estimate the coronary blood flow velocity. This is a simple, inexpensive, quantitative, reproducible, and continuous variable method. Many studies have been conducted on TFC assessment in ST elevation myocardial infarction (STEMI) patients..ObjectivesThe present study is aimed to measure the TFC in the coronary arteries of UA/NSTEMI patients to find abnormalities in diseased or patent vessels and compare with the normal values..Patients andMethodsThe participants were 105 consecutive UA/NSTEMI patients who underwent coronary angiography in Shahid Rajaie Cardiovascular Medical and Research Center, Tehran, Iran in 2009. Exclusion criteria were history of CABG, PCI, or STEMI or presence of occluded arteries in angiography. We measured the coronary TFC in these patients. We examined also 55 stable patients without coronary lesions and with TIMI 3 flow to have an estimation of normal TFCs..ResultsFrom a total of 105 patients, 25 (23.8%) had no significant coronary lesion (> 60%); 35 (33.3%) were diagnosed with single vessel disease; 22 (21%) were 2VD; and 23 (21.9%) were 3 VD.). In overall, mean TFC in UA/NSTEMI group was 28.7 (± 14) frames compared to 23.8 (± 7.8) frames in the normal group (P < 0.05). In the vessels with significant lesions, TFC was significantly higher than normal (30.84 vs. 23.8; P < 0.001) and also significantly higher than patent vessels of the same patients (30.84 vs. 26.10; P = 0.029). In these patients, patent vessels had higher TFC values compared to normal coronaries (26.10 vs. 23.8), but the difference was not significant (P = 0.12). In the patients with significant lesions, mean TFC was higher than the same value in acute coronary patients without significant lesions (29.3 vs. 27.2), but the difference was not significant (P = 0.114). In the patients who underwent PCI and stenting, TFC changed significantly after PCI toward the normal value (P = 0.001). In the patients with elevated cardiac enzymes, TFC was higher but the difference was not significant (P = 0.35)..ConclusionsPatent coronaries of UA/NSTEMI patients have a trend to higher TFCs compared to normal values. Presence of significant coronary lesions in these patients significantly increases TFC..Keywords: Angina, Unstable, Myocardial Infarction, Coronary Angiography
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Pages 99-103BackgroundCatheter Related Blood stream Infections (CRBSI) are prevalent and a potentially fatal complication pertaining to cardiovascular implant devices. There have been no major studies on bacterial colonization of catheters in cardiovascular patients in Iran..ObjectivesTo evaluate the incidence of catheter colonization of bacteria in the largest Iranian cardiovascular center..Patients andMethodsMarch 2011 to 2012, Cauterization procedures performed on 60 patients hospitalized in Rajaie Cardiovascular Medical and Research Center, Tehran, Iran, with arterial or venous catheterization, inserted 48 hours or more, catheter evaluations done by culture methods. Blood cultures were also obtained simultaneously..ResultsForty-four out of 60 catheters (73.3%) were positive with a significant colony count. Of 44 positive cases, 11 patients had positive blood culture. Three most frequently isolated microorganisms were Staph Albus [14 (32%)], Entrococcu [12 (27%)] and Acinetobacter [5 (11%)]. gram-positive cocci were sensitive to Vancomycin and Linezolid and gram-negative bacilli were sensitive to Amikacin, Gentamicin, Tobramycin and Imipenem..ConclusionsThe study findings revealed that the catheter infection in our patients had sources other than normal skin flora. These results will assist in determining the possible source of the infections, furthermore, how they are transmitted, moreover aid in controlling and preventing these dangerous in- infections..Keywords: Catheter, Related Infections, Cardiovascular Diseases, Bacteremia, Hospitalization, Iran
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Pages 104-105A 64-year-old female with history of previous aortoiliac occlusion and aortoiliac bypass operation four months ago presented with dyspnea, ascites and leg edema. She has been suffering from bloody diarrhea since two weeks earlier. Laboratory data showed important eosinophilia and stool examination was positive for Strongyloides stercoralis. Patient had clinical signs of heart failure. A cardiac MRI revealed hypersignal subendocardium in favor of endomyocardial fibrosis. Hypereosinophilic syndrome is defined by persistent hypereosinophilia for more than 6 months. The association with different etiologies is known but the report of cardiac involvement due to S. stercoralis infection is not very common. Cardiac manifestation is characterized by a restrictive cardiomyopathy due to toxic damage produced by activated eosinophils..Keywords: Endomyocardial Fibrosis, Strongyloides stercoralis, Magnetic Resonance Imaging
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Pages 106-108A 53-year-old male was referred to our Department for refractory primary hypertension. Despite high doses of 6 anti-hypertensive drugs, ambulatory monitoring of blood pressure (BP) revealed a mean BP of 160/90 mmHg. Under local anaesthesia, renal denervation with radiofrequency was performed supported by high-resolution 3D angiography, which helped confirm the position of the applications in a spiroid fashion..Keywords: Hypertension, Cardiovascular Disease, Denervation, Angiography