فاطمه رحیمی

C-Kit, a receptor tyrosine kinase involved in intracellular signaling, has a mutated form that significantly contributes to the development of certain cancers. This study aimed to evaluate a series of benzo[a]phenazin-5-ol-tethered tri-substituted methane derivatives as potential pharmacophores for inhibiting C-Kit kinase.

Benzo[a]phenazine-5-ol derivatives were sketched and converted into Mol2 files using Marvin software. Their three dimensional (3D) structures were generated and saved in PDB format. Molecular docking studies with the C-Kit kinase (PDB code 1t46) were performed using AutoDock 4.2. Additionally, the derivatives' physicochemical properties, ADME characteristics, and drug-likeness parameters were assessed with the SwissADME online tool.

Molecular docking studies of benzo[a]phenazin-5-ol derivatives (A-L) against C-kit kinase revealed that compounds A and C exhibited greater selectivity and stronger inhibitory effects than the reference drug, Sunitinib. Ligplot analysis demonstrated that compound A formed four hydrogen bonds with Arg791(A), Ile789(A), and His790(A), while compound C formed two hydrogen bonds with Ile571(A) and Ile789(A). ADME analysis indicated that all compounds, except C, D, and I, are potential P-gp substrates. Drug-likeness analysis showed one or two violations of Lipinski's rule of five.

In summary, molecular docking studies identified compounds A and C as promising lead candidates for inhibiting C-kit kinase, demonstrating superior binding to the active site compared to Sunitinib. ADME and drug-likeness analysis revealed that compound A is a potential P-gp substrate with one violation of Lipinski's rule of five, making it the closest pharmacological match to Sunitinib and a strong candidate for further investigation.

Today, the water resources contamination due to petroleum compounds and its health effects on human and the environment is considered as an important issue. The removal of these pollutants is done by various methods among which, biological methods are superior due to their cost effectiveness, easy access, etc. In this study, a variety of biological methods have been investigated to remove petroleum compounds from water.

Keywords and phrases such as Bioremediation, petroleum compounds, Bio adsorbents, petroleum removal, petroleum bioremediation, petroleum phytoremediation and their Persian equivalents were searched in the databases include; Google Scholar, PubMed, ScienceDirect, Magiran, ResearchGate, SID, Wiley to find content related to the current study and after reviewing the available studies, 28 of the most relevant articles from 2018 to 2023 were reviewed for the intended study.

According to the research carried out, bioremediation and the use of natural adsorbents along with native microorganisms that decompose hydrocarbons are noted to remove petroleum compounds. Although these methods require to long time and adaptation of microorganisms to environmental conditions but due to benefits such as high efficiency, biocompatibility, safety, cheapness and availability, they are recommended over other existing methods to remove petroleum pollution from water. Furthermore, to increase the speed of bioremediation by microorganisms, strategies of biological stimulation and reinforcement can be used, which increases the growth of petroleum hydrocarbon decomposers.

Considering the importance of health and preserving human health and the environment, the removal of petroleum pollutants from the aquatic environment is very important. A review of the biological methods used to remove these pollutants shows the use of microorganisms that decompose petroleum compounds, that adapted to environmental conditions and parameters such as temperature, pH, etc. over time and generate biosurfactant, is recommended in the long term.

Considering the tendency of the new generation, especially students, to use virtual spaces, it seems that the internet can be considered as a medium of influence in academic and personal life. The aim of the study was to predict body dysmorphic based on internet addiction and loneliness in medical students.

The type of present study was descriptive-correlation. 190 medical students from west of Mazandaran were included in the study by stratified random sampling method. Data were collected using Kimberly Young's Internet Addiction Questionnaire, Rabiei et al.'s body dysmorphic Questionnaire, and Russell's Loneliness Questionnaire. Descriptive statistics, Pearson correlation test and stepwise regression were used for analysis.

The results showed that there was a significant relationship between internet addiction and feeling lonely with body dysmorphic in West Mazandaran medical students (P<0.01). The results of the regression analysis showed that in the first step, the feeling of loneliness variable alone predicts 44% of the variance of the body dysmorphic variable (P<0.01). In the second step of this analysis, the variable of internet addiction was added as another variable after the variable of loneliness into the prediction equation of students' body dysmorphic, and with the addition of this variable, the predictive power increased to 50% (P<0.01).

the variables of internet addiction and feeling of loneliness are predictors of body dysmorphic in medical students, in such a way that body dysmorphic disorder increases with more feeling of loneliness and higher dependence on the internet.

Cardiovascular diseases are one of the most important causes of death and disability worldwide, and interventions to prevent risk factors and timely treatment can prevent mortality.

The objective of the study was to compare the epidemiology of CABG with an emphasis on the awareness of changes in demographic characteristics.

This cross-sectional study was conducted on patients referred to the specialized cardiology hospital of Guilan province who underwent CABG. The study period was divided into two time periods: 2018-2019 and 2020-2021, and the demographic and clinical characteristics of the patients and the outcomes of the operation were compared between the two time periods. Chi-square test, Fisher's exact test and Mann-Whitney U test were used to compare qualitative and quantitative variables.

The median age of people in the period of 2018-2019 was 60 years and in the period of 2020-2021 was 60.5 years. The BMI of the patients in the first and second period respectively was 26.7 and 26.6 kg/m2. In the first period, 69.3% were male, 57. 7% lived in the city, and 43.5% smoked. The distribution of age, sex, body mass index, smoking and residence of people in the two studied periods were similar (P-value>0.05). FBS, LDL, TG and Chol of the patients were higher and HDL was lower in the second period. The percentage of people with DM, IHD, CHF, MI was lower in the first period. But this difference was not statistically significant (P-value>0.05).The mean diastolic blood pressure in the first period was lower and a higher percentage of people had HLP and HTN in the second period, which was statistically significant (P-value<0.05).

According to the results of the research, the incidence or progress of previous diseases should be reduced to a great extent by properly planning and holding training classes in the field of reducing or controlling stress and emphasizing continuous follow-up of one's health status and quitting smoking.

The present study aimed to investigate the relationship between Hardiness psychology and academic well-being and the mediating role of students' Cognitive emotion regulation. The design of this research was descriptive and correlational. The statistical population of the research was made up of all the second high school students in the academic year of 2022-2023 in Qir city of these, 244 people were selected by convenience. Data were collected by Academic Well-being Questionnaire (AWBQ; Tuominen-Soini et al, 2012), the Psychological Hardiness Questionnaire  (PHQ; Kobasa et al, 1982), and the Cognitive Emotion Regulation Questionnaire (CERQ; Garnefski- Kraaij, 2006) The data were analyzed using the structural equation modeling method. The results showed that Hardiness psychology directly and positively affects academic well-being (P<0.05). Other results showed that cognitive emotion regulation has a mediating role between Hardiness psychology and academic well-being (P<0.05); Also, the fit indices showed that the proposed model has a good fit. Therefore, according to the results of the present study and the role of Hardiness psychology and cognitive emotion regulation in the academic well-being of students, it is suggested to develop and implement educational programs in this field for students.

Population aging is accompanied by an increase in the elderly's demand for long-term care, which is mainly provided by family caregivers. Providing quality elderly care, while maintaining the health of caregivers, requires recognition of facilitators and the educational needs. Therefore, this study aims to investigate facilitators of elderly care at home and the educational needs of the family caregivers of older adults in the south of Tehran, Iran.

This is a qualitative study using the conventional content analysis method. To collect data, we conducted semi-structured telephone interviews. Seventeen family caregivers aged ≥18 years with at least one month of caregiving experience and at least six hours of caregiving per week were selected using purposive and snowball sampling methods until data saturation from January to April 2021. After transcribing the recorded interviews, the data were entered into the MAXQDA 2018 software and analyzed.

Personal factors included personal characteristics of caregivers, Capability in caregiving, perceived benefits of caregiving, and self-care activities of caregivers. Interpersonal factors included proper relationship with older adults, older adults’ partial  dependence on caregivers, cooperation and support of family members, and receiving others’ support. Supportive environments included physical environment, receiving support from work environments and organizations providing elderly care services. The most important educational needs of family caregivers were the needs to learn how to prepare nutritious foods for the elders, the way to nourish older adults with dysphagia, and how to move the physically disabled older adults.

Family caregivers of older adults in the south of Tehran should have access to affordable elderly care and home care services based on their educational needs that require planned support from service providers.

The purpose of this study was to investigate the relationship between organizational citizenship behavior and job performance among public librarians in Ilam province.

The methodology applied for this research was descriptive and correlational in nature, with data collected through survey methods. Utilizing the organizational citizenship behavior questionnaire developed by Podsakoff et al. (1990) and the job performance questionnaire by Paterson (1970), the study focused on the librarians in Ilam province in 2023. With three predictor variables considered, a confidence level of 0.95, test power of 0.90, and G*Power software indicating a minimum required sample size of 99 individuals, a total of 103 participants were included in the analysis after accounting for an additional 5% sample volume.

The findings revealed significant relationships between altruism and civil virtue among librarians, as well as associations between respect for librarians and their job performance. However, no significant correlations were found between conscientiousness or chivalry and job performance.

In democratic systems, increasing attention is being placed on citizen participation. Active engagement from organizational members as good citizens is crucial for fostering positive behaviors within an organization. Recognizing organizational citizens as valuable resources, their behavior plays a key role in overall success. This study highlights the positive link between organizational citizenship behavior and librarian performance in Ilam province.

Value: 

This study adds to the existing literature by examining the impact of organizational citizenship behavior on librarian job performance and underscores the importance of this relationship in enhancing professional performance. The results can offer valuable insights for cultural officials, public library managers, and policymakers seeking to motivate library staff effectively.

Depression in teenagers can severely disrupt personal and professional growth. The aim of the present study was to compare the effectiveness of metacognitive therapy and compassion-based therapy on emotional repression and self-disclosure in adolescents with depression.

It was a semi-experimental research based on a pre-test and post-test design with a control group. The statistical population of the research included teenagers suffering from depression who referred to the Education Counseling Center of District 5 of Tehran in 2022, and 45 people were selected by available sampling method. Randomly, they were placed in three groups: metacognitive therapy, compassion-based therapy, and control group. Experimental group 1 underwent metacognitive therapy sessions and experimental group 2 underwent compassion therapy sessions. The research tools included Beck's (1996) depression questionnaire, Larson and Justin's (1990) emotional suppression questionnaire, and Weinberger's (1971) adjustment questionnaire. Data were analyzed using SPSS-24 software and multivariate covariance test.

The results showed that there is a significant difference between the two experimental groups and the control group (P<0.05). Also, metacognitive therapy was more effective than compassion therapy in reducing emotional suppression and self-disclosure in adolescents (P<0.05).

Based on the findings of the research, metacognitive therapy with emotional reorganization, cognitive control and tolerance led to the reduction of emotional repression and self-disclosure in adolescents with depression; Therefore, it is suggested to use these methods along with other treatment methods to improve the quality of life of teenagers suffering from depression.

Hafez's poetry has the greatest capability to be analyzed from the perspective of discourse analysis due to the accumulation of metaphors and ambiguities that double its evasiveness and fluidity. In the meantime, examining the fatalistic propositions in Hafez's poetry, beyond their apparent implication of extreme belief in fate reveals the connection of these propositions with the social, political, and ideological realities of the time of the narration of the text, and factors such as "historical context" and "power relations in the society". Considering the discourse of fatalism in Hafez's poetry as a construction of the relationship between the structure and themes of his poetry with extra-textual factors, the present research tried to give a new formulation of it that is compatible with Hafez's free-thinking and critical views. This study is written using a descriptive-analytical method. The research showed that Hafez, behind the face of the text, and beyond the outward expressions of his poetry, which speaks of submission to fate, is trying to build a critical discourse through the use of language, to bring about changes in the macro social structures and struggle with power institutions and ideologies related to them. In the process of a language game, while expanding his popular ideology under the guise of fatalism, he pursues a goal beyond the spread of fatalism in his poetry and tries to reproduce and induce a new message and meaning of fatalism in the audience's mind.