ahmed galal
-
Introduction
Scleroma is a chronic, specific granulomatous disease that affects the head and neck mucosa. Its common sites are the nose and larynx; however, it might affect other areas. One of the rare sites to be affected is the middle ear and mastoid cavity, for which the term otoscleroma was coined. We present such a rare case in this report.
Case Report:
A 47-year-old patient with a history of both old laryngoscleroma and recent Rhinoscleroma. He presented with symptoms of ear discharge and facial palsy. Examination revealed complete facial nerve palsy and an external auditory canal polyp. A decision was made to perform subtotal petrosectomy with facial nerve decompression and maximum debulking to be sent for histopathology. The result came typical of otoscleroma
ConclusionOtoscleroma is a fairly rare occurrence. It might be primary, with no evidence of Scleroma in other sites or following rhino and/or laryngoscleroma. It might be unilateral or bilateral. It might mimic the clinical picture of chronic suppurative otitis media and its complications. Tympano-mastoidectomy is recommended to stop the discharge, obtain a proper biopsy and decompress the facial nerve if needed. Otoscleroma should be suspected in the case of previous Scleroma in other sites, and otitis media or complications like manifestations.
Keywords: Otoscleroma, Rhinoslceroma, Facial Palsy, Subtotal Petrosectomy, Facial Nerve Decompression -
Purpose
Herein we introduce a simple and sensitive sensor for the electrochemical determination of neurotransmitters compounds and anti-Parkinson drugs.
MethodsThe electrochemical sensor (Au/CILCE) based on gold nanoclusters modified carbon ionic liquid crystal (ILC) electrode was characterized using scanning electron microscopy and voltammetry measurements.
ResultsThe effect of ionic liquid type in the carbon paste composite for the electro-catalytic oxidation of L-dopa was evaluated. Highest current response was obtained in case of ILC compared to other studied kinds of ionic liquids. The effective combination of gold nanoclusters and ILC resulted in extra advantages including large surface area and high ionic conductivity of the nanocomposite. L-dopa is considered one of the most important prescribed medicines for treating Parkinson’s disease. Moreover, a binary therapy using L-dopa and carbidopa proved effective and promising as it avoids the short comings of L-dopa mono-therapy for Parkinson’s patients. The Au/CILCE can detect L-dopa in human serum in the linear concentration range of 0.1 μM to 90 μM with detection and quantification limits of 4.5 nM and 15.0 nM, respectively. Also, the Au/CILCE sensor can simultaneously and sensitively detect L-dopa in the presence of carbidopa with low detection limits.
ConclusionThe sensor is advantageous to be applicable for electrochemical sensing of other biologically electroactive species.
Keywords: Neurotransmitters, Anti-Parkinson drugs, Gold nanoclusters, Carbon ionic liquid crystal electrode, L-dopa, Carbidopa -
PurposeDrug-abuse, namely morphine (MO) affects the metabolism of neurotransmitters such as dopamine (DA). Therefore, it is crucial to devise a sensitive sensing technique to simultaneously determine both compounds in real samples.MethodsThe fabrication of the sensor is based on in situ modification of a carbon paste (CP) electrode with cobalt oxide nanoparticles, graphene, and ionic liquid crystal in presence of sodium dodecyl sulfate; CoGILCCP-SDS. The modified sensor is characterized using scanning electron microscopy, electrochemical impedance spectroscopy and voltammetry measurements.ResultsElectron transfer kinetics and analytical performance of the proposed sensor were enhanced due to the synergistic role of all the modifiers. The simultaneous determination of MO and DA achieved low detection limits of 0.54 nmol L−1 and 0.25 nmol L−1, respectively. Besides, a carbon-based electrochemical sensor is fabricated for the nano-molar determination of MO in real samples and formulations. The sensor showed fouling resistance and anti-interference ability in presence of other species in human fluids. The real sample analysis of MO was successfully achieved with good recovery results in urine samples and pharmaceutical tablets. Linear dynamic range, sensitivity, detection limit and quantification limit of MO in urine were 5 nmol L−1 to 0.6 μmol L−1, 6.19 μA/μmol L-1, 0.484 nmol L−1 and 1.61 nmol L−1, respectively.ConclusionThis sensor has great ability to be extended for electrochemical applications in assaying of many drugs.Keywords: Morphine, Dopamine, Cobalt oxide nanoparticles, Graphene, Ionic liquid crystal
- در این صفحه نام مورد نظر در اسامی نویسندگان مقالات جستجو میشود. ممکن است نتایج شامل مطالب نویسندگان هم نام و حتی در رشتههای مختلف باشد.
- همه مقالات ترجمه فارسی یا انگلیسی ندارند پس ممکن است مقالاتی باشند که نام نویسنده مورد نظر شما به صورت معادل فارسی یا انگلیسی آن درج شده باشد. در صفحه جستجوی پیشرفته میتوانید همزمان نام فارسی و انگلیسی نویسنده را درج نمایید.
- در صورتی که میخواهید جستجو را با شرایط متفاوت تکرار کنید به صفحه جستجوی پیشرفته مطالب نشریات مراجعه کنید.