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فهرست مطالب نویسنده:

ali ashraf

  • Parinaz Sedadi, Ali Ashraf, Ali Pourramazni, Roghaye Zareh
    Background

    Post-traumatic stress disorder (PTSD) is a psychological disorder resulting from a previous traumatic experience. The objective of the present study was to investigate the prevalence of PTSD and its related risk factors among Intensive Care Unit (ICU) survivors.

    Methods

    A total of 152 patients were followed up prospectively for one month. All included participants had Glasgow Coma Scale scores ranging from 12 to 15. PTSD was assessed using a Persian-translated version of the PTSD Checklist (PCL). Data were analyzed using SPSS 22.0 software.

    Results

    Among the participants, seventy-two (47.4%) men and eighty (52.6%) women with a mean age of 54.5 ± 19.19 years responded to the questionnaire. The prevalence of post-discharge PTSD was 87.5%. There was a significant correlation between PTSD mean score and clinical factors such as hospitalization reason, self and familial history of psychological disorders, and Richmond Agitation Sedation Score (RASS) (p < 0.05).

    Conclusions

    Our findings suggest that, despite often being ignored, post-discharge PTSD is a significant psychological issue for ICU survivors. This highlights the importance of supportive care plans for patients with a history of mental disorders and agitation. The involvement of psychotherapists is crucial to improving postdischarge quality of life.

    Keywords: Post-Traumatic Stress Disorder, Intensive Care Unit, Trauma, ICU Survivors
  • علی اشرف هواسی*، فرامرز نعمتی میری
    بحران های قومی دهه اول انقلاب اسلامی زمینه ساز تاثیرات بسیاری بر امنیت ملی جمهوری اسلامی ایران بود. سوال اصلی این گونه مطرح شده است که حرکت های تجزیه طلبانه در یک دهه اول انقلاب اسلامی چه تاثیری بر امنیت ملی جمهوری اسلامی ایران داشته است؟ در پاسخ این فرضیه مطرح شده است که حرکت های تجزیه طلبانه در یک دهه اول انقلاب اسلامی زمینه ساز تضعیف امنیت ملی جمهوری اسلامی ایران شده است. یافته های مقاله نشان می دهد که به طور کلی در دهه اول انقلاب اسلامی، وجود بحران های مختلف در ابعاد گوناگون زمینه ساز به خطر افتادن امنیت ملی جمهوری اسلامی ایران شد. در این بین، وجود گروه های تجزیه طلب در کردستان، سیستان و بلوچستان، گنبد و... زمینه ساز تضعیف امنیت اقتصادی، سیاسی، نظامی و... شد. از سوی دیگر، از آن جا که جمهوری اسلامی ایران درگیر جنگ با عراق بود و همچنین به تازگی با سرنگونی حکومت پهلوی یک حکومت جمهوری اسلامی تاسیس شده بود، وجود حرکت های تجزیه طلبانه بیش از پیش در به مخاطره افکندن امنیت ملی جمهوری اسلامی ایران موثر بود. نوع روش تحقیق حاضر، توصیفی - تحلیلی می باشد. همچنین در جهت حمایت نظری از این تحقیق، از نظریه های امنیت ملی استفاده شده است.
    کلید واژگان: بحران، بحران های قومی، امنیت ملی، تجزیه طلبی
    Ali Ashraf *, Faramarz Nemati Miri
    The ethnic crises of the first decade of the Islamic Revolution caused many effects on the national security of the Islamic Republic of Iran. The main question has been raised as follows: What effect did separatist movements have on the national security of the Islamic Republic of Iran in the first decade of the Islamic Revolution? In response to this hypothesis, it has been proposed that separatist movements in the first decade of the Islamic Revolution have become the basis for weakening the national security of the Islamic Republic of Iran. The findings of the article show that, in general, in the first decade of the Islamic Revolution, the existence of various crises in various dimensions contributed to endangering the national security of the Islamic Republic of Iran. In the meantime, the presence of separatist groups in Kurdistan, Sistan and Baluchistan, Gonbad, etc. caused the weakening of economic, political, military, etc. security. On the other hand, since the Islamic Republic of Iran was involved in the war with Iraq and also had recently established an Islamic Republic government with the overthrow of the Pahlavi government, the existence of separatist movements is more effective in jeopardizing the national security of the Islamic Republic of Iran. was The current research method is descriptive-analytical. Also, in order to theoretically support this research, national security theories have been used.
    Keywords: Crisis, Ethnic Crises, National Security, Separatism
  • Ali Ashraf*, Zoheir Rehanian, Kamran Ezzati, Roxana Mahdavi, Habib Eslami Kenarsari, Sedigheh Samimian
    Introduction

    Nursing is a job with high physical activity; therefore nursed are at high risk of work-related musculoskeletal disorders, including neck pain. 

    Objective

    This study aims to investigate the prevalence and risk factors of neck pain in nurses working in intensive care units (ICUs) of teaching hospitals in Rasht, north of Iran.

    Materials and Methods

    In this cross-sectional study, 120 nurses working in the ICUs of seven educational therapeutic hospitals in Rasht in 2019 participated. Required data were collected using a two-part questionnaire. The first part surveyed sociodemographic information. The second part was the Persian version of the neck disability index. For statistical analysis, chi-square test, Fisher’s test, and logistic regression analyses were used.

    Results

    The mean age of nurses was 35.7±5.8 years, and 97.5% of them were female. Their mean work experience was 11.1±5.6 years. The overall prevalence of neck pain was 82.5% (n=99). The frequency of neck pain among nurses with more than 15 years of work experience (P=0.019), age 30-39 years (P=0.031) and no sports activity (P=0.031) was more. The risk of neck pain in nurses who had a history of exercise was 3.277 times higher (95% CI; 1.030%, 10.43%, P=0.045) and in married nurses was 2.92 (95% CI; 0.920%, 9.274%, P=0.069) that was borderline significant.

    Conclusion

    There is a high prevalence of neck pain among nurses working in the ICUs of educational therapeutic hospitals in Rasht. Hence, it is necessary for hospital managers to take the necessary measures to reduce these complications in order to protect the health of nurses and improve the quality of patient care.

    Keywords: Neck Pain, Intensive Care Units (Icus), Critical Care Nursing
  • Zoheir Reihanian, Ali Ashraf, Malihe Mashategan, Behrad Eftekhari, Zahra Pourhabibi, Nooshin Zaresharifi*
    Background

    Changes in the body fluid and serum electrolyte status following major operations, such as brain tumor resection, are always expected. These changes can increase post-operation morbidity and mortality.

    Objectives

    We aimed to evaluate the changes in serum electrolyte levels and renal function parameters in brain tumor patients after operation.

    Materials & Methods

    This cross-sectional study was performed on 168 patients with supratentorial tumors in Poursina Hospital, Rasht City, Iran, in 2020. The study parameters included patients’ demographics, hemodynamic stability, serum sodium, potassium, blood urea nitrogen (BUN) and creatinine levels, urine specific gravity, and urinary output, measured immediately and 12 hours after the operation.

    Results

    This study revealed statistically significant increases in serum sodium level (from 139.70±5.60 meq/L to 140.34±6.23 meq/L, P=0.002), urinary output (from 1043.70±455.00 mL to 1967.50±661.10 mL, P=0.008), urine specific gravity (from 1.010±0.007 to 1.012±0.008, P=0.011), and in serum BUN level (from 17.46±6.92 to 18.41±6.40, P=0.001), but significant decrease in serum potassium level (from 3.88±0.49 meq/L to 3.78±0.28 meq/L, P=0.017) during the first 12 hours after operation. However, the change in serum creatinine level was not significant (from 1.18±2.08 mg/dL to 1.17±2.08 mg/dL, P=0.787).

    Conclusion

    Significant changes in serum electrolytes (sodium and potassium) and renal function indicators (urine output, specific gravity, and serum BUN) are expected within the first 12 hours after brain tumor operation.

    Keywords: Brain neoplasms, Operation, Electrolytes, Inappropriate ADH syndrome, Diabetes insipidus
  • Ali Ashraf*, Shahrokh Yousefzadeh-Chabok, Mehrnoosh Shakeri Boroujeni, Amirhossein Fahimi, Talat Kaviyani Jebeli, Habib Eslami Kenarsari
    Background and Aim

    One of the common complications in craniotomy surgery is bleeding, which is associated with serious and sometimes life-threatening complications. It is essential to accurately estimate the amount of blood lost and compensate for it. This study was conducted to examine the relationship between suctioned blood volume, blood gauze volume, and hemoglobin (Hb) drop rate after craniotomy surgery and identify factors affecting it in hospitalized patients. The results of this research can help doctors accurately predict the amount of blood loss during the operation and avoid unnecessary blood transfusions.

    Methods and Materials/Patients:

     Ninety-seven patients with a history of craniotomy surgery in the first 6 months of 2019 were included in the study. The information on the patients was recorded based on laboratory documentation. To calculate the volume of blood lost during the operation, the volume of blood suctioned from the operation description sheet and the volume of blood absorbed by gauzes were calculated and recorded by weighing them. Data were analyzed with SPSS software, version 22.

    Results

    In this study, 32% of patients received blood during craniotomy. According to the obtained results, the blood volume obtained from blood gauze and suctioned blood and the total blood volume were significantly related to Hb drop, and their ability to predict Hb drop were 6.6%, 14.1%, and 11.2%, respectively. Based on Spearman’s correlation coefficient, the intensity of the correlation between the number of blood gauzes and the amount of blood obtained from blood gauzes was greater than the change in the volume of blood sucked and the amount of total bleeding.

    Conclusion

    This study showed that measuring the blood volume of gauze consumed in craniotomy surgery can be more effective in predicting the amount of blood loss and Hb drop of the patient after the operation even than the amount of suctioned blood.

    Keywords: Craniotomy, Hemoglobin (Hb), Anemia, Brain Tumor, Bloodtransfusion
  • Mohammad Taghi Ashoobi, Maryam Shakiba, Atoosa Keshavarzmotamed, Ali Ashraf *
    Background

    Unwanted postoperative hypothermia is an unpleasant event that can cause various complications.

    Objectives

    As this serious complication and its provoking causes have not been investigated sufficiently, this study was designed and conducted to determine the prevalence of hypothermia and its associated factors in the post-anesthesia care unit after elective surgery.

    Methods

    Four hundred patients undergoing elective surgeries were enrolled in the present cross-sectional research after termination of surgery and at the time of arrival at the post-anesthesia care unit of Poursina Public University Hospital. The tympanic membrane temperature was measured and recorded at the time of arrival at the post-anesthesia care unit and every 30 minutes after arrival. The required data were collected in a researcher-made checklist and analyzed after entering the SPSS software version 25.

    Results

    Considering the 5% error, it can be said that the prevalence of hypothermia in patients undergoing elective surgery ranges from 20 to 28% at the time of arrival at the post-anesthesia care unit and 18.5 to 26% 30 minutes after arrival.

    Conclusions

    More than a quarter of patients experienced hypothermia following elective surgery. Therefore, appropriate treatment and control measures are necessary to manage this complication, particularly in patients with predisposing risk factors and comorbidities.

    Keywords: Elective Surgery, Hypothermia, Post-anesthesia Care Unit, Prevalence
  • علی اشرف، رامین ابراهیمیان جیکتاجی، مصطفی سعیدی نیا، گلاره بی آزار*، حبیب اسلامی کنارسری، محمدکاظم بهجت

    زمینه :

    در روند درمان بیماران کووید-19 بستری در بیمارستان، یکی از عوارضی که بیماران را تهدید می کند، آسیب های ریوی از قبیل باروتروماست.

    هدف :

    مطالعه حاضر به منظور بررسی فراوانی عارضه باروترومای ریوی در بیماران مبتلا به کووید-19 بستری در بخش های مراقبت ویژه بیمارستان های رازی و پورسینا شهر رشت انجام شد.

    روش ها:

     این مطالعه، یک مطالعه گذشته نگر است که روی بیماران با تشخیص کووید-19 بستری شده در بخش های مراقبت ویژه بیمارستان های آموزشی درمانی (پورسینا و رازی) شهر رشت در سال 1399 انجام شد. چک لیستی که شامل اطلاعات زمینه ای بیماران و عوارض ریوی بیماران بود، توسط دستیار بیهوشی ثبت شد. 

    یافته ها :

    در کل، اطلاعات 140 بیمار مورد آنالیز قرار گرفت. 81 بیمار (57/9 درصد) تحت تهویه غیرتهاجمی و 59 بیمار (42/1 درصد) تحت تهویه تهاجمی با ونتیلاتور قرار گرفتند. در 9 مورد (6/4 درصد) عارضه باروتروما مشاهده شد که در این میان، 8 مورد (88/9 درصد) عارضه پنوموتوراکس و یک مورد (11/1 درصد) عارضه پنوموتوراکس همزمان با آمفیزم ساب کوتانیوس بود. نتایج نشان داد بروز باروتروما در بیمارانی که تهویه تنفسی تهاجمی دریافت کرده بودند، به طور معنی داری بیشتر بود (0/003=P) اما از نظر انواع تهویه غیرتهاجمی تفاوت معنی داری مشاهده نشد (P>0/05).<p)

    نتیجه گیری :

    شیوع باروتروما در بین بیماران کووید-19 در بیمارستان های مورد مطالعه پایین بود که نشان دهنده عملکرد مناسب پزشکان معالج و رعایت دستورالعمل های استاندارد است.</p)

    کلید واژگان: بیمار، کووید-19، باروتروما، تهویه مکانیکی
    Ali Ashraf, Ramin Ebrahimiyan Jektaji, Mostafa Saeedinia, Gelareh Biazar*, Habib Eslami Kenarsari, MohmmadKazem Behjat
    Background

    In the treatment process of hospitalized patients with COVID-19, one of the threatening complications is pulmonary complications such as barotrauma.

    Objective

    This study aims to investigate the prevalence of barotrauma in COVID-19 patients admitted to intensive care units (ICU) of two hospitals in Rasht, Iran.

    Methods

    This retrospective study was conducted on COVID-19 patients admitted to the ICUs of Razi and Poursina hospitals in Rasht in 2020. Their files were studied, and their demographic/clinical data and pulmonary complications were extracted using a checklist by an anesthesia resident. 

    Results

    Out of 140 patients, 81(57.9%) received non-invasive mechanical ventilation and 59(42.1%) had invasive ventilation. Barotrauma was observed in 9 cases (6.4%), 8(88.9%) in the form of pneumothorax and one (11.1%) in the form of both pneumothorax and subcutaneous emphysema. The results showed that the incidence of barotrauma was significantly higher among patients who received invasive mechanical ventilation (P=0.003). No significant difference was observed among patients received non-invasive ventilation (P>0.05). 

    Conclusion

    The prevalence of barotrauma among COVID-19 patients in the study hospitals is low, which indicates the proper performance of the attending physicians and compliance with the standard guidelines.

    Keywords: COVID-19, Barotrauma, Mechanical Ventilation
  • Alia Saberi, Sajjad Saadat*, Azin Boromand, Ali Ashraf, Robabeh Soleimani
    Background

    The COVID-19 virus epidemic has caused a major physical and psychological burden on nurses in Iran and around the world.

    Objectives

    The purpose of this study was to investigate the role of anxiety and resilience in predicting occupational fatigue in nurses during the COVID ‐ 19 virus epidemic in Iran.

     Materials & Methods

    This cross-sectional online survey was conducted on the nurses of Razi and Porsina public hospitals in Rasht, north of Iran. A total of 160 nurses of were selected using simple random sampling method. Data were collected using the Swedish occupational fatigue inventory (SOFI), the corona disease anxiety scale (CDAS) and the Connor-Davidson resilience scale (CD-RISC).

    Results

    Participation rate was 87.5%. The score level of most nurses in CDAS was low to moderate. The CDAS score was higher in women and those who work in the COVID units than those who work in both the COVID and non-COVID units. The CD-RISC score was higher in married people than singles and in people with permanent employment status than in contract and temporary employment status. SOFI was positively correlated with CDAS and negatively correlated with CD-RISC; But CDAS and CD-RISC were not significantly related (p<0.05). In multivariate linear regression model. Anxiety was the only significant independent predictor of occupational fatigue (B=1.16, P<0.001).

    Conclusion

    Despite the COVID-19 epidemic crisis in the fourth wave and high mortality, anxiety level in nurses was low and moderate, which can be attributed to the COVID-19 vaccine. But the anxiety score still played an important role in occupational fatigue. It is suggested that appropriate interventions be developed and implemented to improve nurses' anxiety to stressful epidemic conditions of Covid-19 and thereafter.

    Keywords: COVID-19, anxiety, resilience, occupational fatigue, nurses
  • علی اشرف، پگاه آقاجانزاده، نیلوفر حامدی، ملیحه اکبرپور*
    زمینه

    بیمارانی که تحت اعمال جراحی بزرگ ارتوپدی قرار می گیرند، به دلیل از دست دادن خون، اختلالات الکترولیتی، عفونت و وجود سایر بیماری های همراه در ریسک ابتلا به آسیب حاد کلیوی هستند. در این مطالعه، فراوانی و عوامل خطر بروز آسیب حاد کلیوی بررسی شد.

    هدف و روش ها

    این پژوهش مقطعی تحلیلی با حجم نمونه 180 نفر انجام شد. جامعه مورد مطالعه بیماران تحت عمل جراحی ارتوپدی بودند. معیارهای خروج شامل سابقه بیماری مزمن کلیه و سابقه دیالیز بود. اطلاعات بیمار شامل سن، جنسیت، سابقه دارویی، سابقه بیماری زمینه ای، تغییرات کراتینین، مدت زمان جراحی، حداقل فشار متوسط شریانی حین و بعد از عمل و استفاده از اینوتروپ در حین و بعد از عمل و سطح کراتینین اندازه گیری و ثبت شد. 

    یافته ها

    میزان بروز آسیب حاد کلیوی 11/11 درصد بود. میانگین سنی بیماران 22/8±47/3 سال بود. بین مصرف برخی داروها، مدت زمان جراحی، حداقل فشار متوسط شریانی و مصرف اینوتروپ رابطه معنا داری مشاهده نشد. بروز آسیب حاد کلیوی با سابقه بیماری قلبی، دیابت و سابقه بیماری کلیوی ارتباط معنا داری داشت. رگرسیون خطی چندگانه نشان داد با هر واحد افزایش کراتینین قبل از عمل و وجود بیماری کلیوی قبل از عمل، کراتینین بعد از عمل 0/3 افزایش می یابد.

    نتیجه گیری

    بروز نارسایی حاد کلیه پس از جراحی ارتوپدی نسبتا زیاد است. نظارت دقیق برعملکرد کلیه قبل، حین و بعد از جراحی مهم است و می تواند از بروز نارسایی حاد کلیه بعد از جراحی جلوگیری کند.

    کلید واژگان: آسیب حاد کلیه، جراحی ارتوپدی، کراتینین، عوامل خطر، بیهوشی
    Ali Ashraf, Pegah Aghajanzadeh, Niloofar Hamedi, Maliheh Akbarpour*
    Background

     Patients who undergo major orthopedic surgery are at risk of acute kidney injury (AKI) due to blood loss, electrolyte disorders, infection, and other co-morbidities. In this study, we aim to investigate the frequency of AKI and its risk factors in patients undergoing major orthopedic surgery in Rasht, Iran.

    Objective

     This is an analytical cross-sectional study on 180 patients undergoing major orthopedic surgery. Those with a history of chronic kidney disease and dialysis were excluded. 

    Methods

     The data including patients’ age, gender, drug history, history of underlying diseases, duration of surgery, mean arterial pressure during and after surgery, and use of inotrope during and after surgery, and creatinine level before and after the surgery. 

    Results

     The mean age of patients was 47.3±22.8 years. The incidence of AKI was 11.11%. The use of some drugs, duration of surgery, MAP, and inotrope use had no significant relationship. The occurrence of AKI had a significant relationship with the history of heart disease, diabetes, and kidney disease. Multiple linear regression analysis results showed that with the increase of one unit in preoperative creatinine level, the postoperative creatinine level increased by 0.3.

    Conclusion

     The incidence of AKI after major orthopedic surgery in Rasht city is relatively high. Careful monitoring of kidney function before, during, and after major orthopedic surgery is important; it can prevent the occurrence of postoperative AKI.

    Keywords: Acute kidney injury, Orthopedic surgery, Creatinine, Risk factor, Anesthesia
  • Zoheir Reihanian, Ali Dolat, Ali Ashraf
    Introduction

     Physicians whether during training years or working years are involved with the shift work system. Night shifts and the sleep deprivation that ensues have many adverse effects both physical and mental. Hence any decrease in doctors’ mental capacities will potentially put his and his patients’ health at risk, we decided to conduct a study to check medical interns’ Visual Short-Term Memory (VSTM) and Response Inhibition Functions changes after a night shift compared to the day before.

    Materials and Methods

     In this study, 32 medical interns from the Guilan University of Medical Sciences were recruited by random sampling. Each participant completed a Pittsburgh Sleep Quality Index questionnaire and was asked about his/her smoking habit and prior night's sleep. Each examinee then was tested in the morning before and after the night shift for VSTM by forward Corsi Block Tapping Test (CBTT) and for Response Inhibition by Stroop Word/Color Test implemented in the PEBL software version 2beta6. The data were coded and analyzed in SPSS v21.

    Results

     There was no significant change in the intern's CBTT and Stroop Test results after a night shift and their VSTM and Response Inhibition Functions remained fairly intact. According to their PSQI results, 29 interns had poor sleep quality and only two had an acceptable PSQI score (5 or less).

    Conclusion

     We argued that the consistent results of the CBTT and the Stroop Color Test could be due to many causes from small sample size to overall lower function under chronic sleep deprivation.

    Keywords: Night Shift, Intern, Visual Short-Term Memory, Response Inhibition, Smoking, Sleep Quality
  • Alia Saberi, Sajjad Saadat *, Ali Ashraf, Masumeh Heydari Lakeh, Marjan Entezari, Hamidreza Hatamian
    Background
    The COVID-19 pandemic has had unpleasant consequences for health care providers, including medical stagers and intern students; due to the importance of this issue, this study was conducted to evaluate anxiety, resilience and burnout.
    Methods
    This cross-sectional analytical study was performed on stager and intern medical students of Guilan University of Medical Sciences in Rasht, Iran. Data were collected using a list containing Student Demographic Information, Maslach Burnout Inventory-Student Survey (MBISS), Academic Resilience Inventory (ARI) and Corona Disease Anxiety Scale (CDAS). Data analysis was performed using SPSS v.19 at the level of significance 0.05.
    Results
    High levels of burnout and anxiety were calculated to be 21.1 and 7%, respectively. Burnout score was higher in people with grade point average less than 17 (p=0.014); burnout score was also higher in males (p=0.009). Other results showed that COVID-19 anxiety score was significantly higher in females (p=0.029). The results of multivariate linear regression indicated that the variables including academic resilience (β=0.330) and COVID-19 anxiety (β=0.218) significantly explain 20% of the variance of burnout in students. Also, with the introduction of demographic variables, it was increased to 31% in which the share of gender variable (β=0.283) was significant in this model.
    Conclusion
    Academic resilience, anxiety and gender had an effective role on the rate of student burnout. Accordingly, it is suggested that health care providers and psychologists pay attention to student empowerment by providing appropriate therapeutic interventions during and after the COVID-19 epidemic.
    Keywords: anxiety, burnout, COVID-19, Medical students, Resilience
  • Yousef Jamshidbeigi *, Aliashraf‎ Mozafari, Amir Reza‎ Jamshidbeigi, Gholamreza‎ Kalevandi ‎, Mohammadreza Kaffashian, Azra Kenarkoohi, Ali Nazari, Iraj Ahmadi
    Background
    COVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Infected subjects are at high risk for coagulation diseases such as venous thromboembolism.
    Objectives
    The aim of the present study was to investigate the consequences of delayed referral of patients with COVID-19 in Ilam.
    Methods
    In this investigation, a present prospective study was performed in 2020 on the registry data of patients with COVID-19 disease in the infectious ward of Shahid Mostafa Khomeini Hospital in Ilam. In this study, the effect of delay in hospitalization from the onset of the first symptom of the disease on death and intubation of patients in special and general wards in 2350 patients with COVID-19 was investigated. The statistical software of SPSS 16 was used for analyzing data.
    Results
    The results of univariate logistic regression analysis for the main causes of death due to COVID-19 disease according to hospitalization in ICU and general ward showed that the variables of age, sex, marital status, heart disease, blood pressure, diabetes, chronic lung disease, chronic disease Kidney, neurological disease, cancer, and delayed referral were statistically significant which were associated with death at the 5% error level. The chance of death for delayed referral in ICU patients is equal (OR ICU ADMISSION = 1.06; 95% CI, 1.01-1.12; P value=0.01) and in normal ward patients (OR =0.88; 95% CI, 0.79-0.97), the P-value=0.01 was obtained.
    Conclusions
    The final regression model which was adjusted to the other variables, in hospitalized patients, each day of delay in hospitalization meant a 0.08% increase in the odds of mortality rate and a 0.05% increase in the odds of intubation.
    Keywords: Referral delay, Complications, COVID-19‎. ‎
  • مریم شریفی لویه، علی اشرف، زوبین سوری، علی مجتهدی، ملک مسعود انصار*
    زمینه و اهداف

      در دسامبر 2019، یک نوع جدیدی از پنومونی کورونا ویروس (SARS-CoV-2) با نام (COVID-19) در ووهان گزارش گردید و به سرعت در سراسر جهان گسترش یافت. این مطالعه به منظور بررسی علایم بالینی بیماران COVID-19 طراحی گردید.

    مواد و روش کار

      در این مطالعه گذشته نگر، ما داده های 132 بیمار فوت شده از COVID-19 را جمع آوری نمودیم. داده های دموگرافیک، اپیدمیولوژیکی و بالینی و نتایج تست های آزمایشگاهی در روزهای 1، 3 و 6 پذیرش تجزیه و تحلیل گردیدند.

    یافته ها

      اکثر موارد در گروه سنی 75-65 بودند که 64/39 درصد آنها مرد بودند. سه روز بعد از پذیرش، 55/3 درصد بیماران فوت نمودند. شایع ترین تظاهرات بالینی شامل سرفه خشک (70/45 درصد) و تب (54/54 درصد) بودند که در حین بستری افزایش یافتند. دیابت و فشار خون شایع ترین بیماری زمینه ای گزارش شدند. لنفوپنی و افزایش تعداد گلبول های سفید در اکثر بیماران مشاهده گردید. سطوح ESR (92/5 درصد) و LDH (94/64 درصد) بالاتر از محدوده نرمال بودند. علاوه بر این، 42/85 درصد و 44/73 درصد بیماران به ترتیب سطوح افزایش یافته ALT و AST داشتند.

    نتیجه گیری

      یافته های این مطالعه نشان داد که مردان با احتمال بیشتری با SARS-CoV-19 آلوده می شوند. بیماری های زمینه ای در میان بیماران شایع بود و علایم بالینی و آزمایشگاهی با افزایش زمان بستری تشدید شد.

    کلید واژگان: COVID-19، ویژگی های بالینی، اپیدمیولوژی، ایران، SARS-CoV-19
    Maryam Sharifi Luyeh, Ali Ashraf, Zobin Souri, Ali Mojtahedi, Malek Masoud Ansar*
    Background and Objective

     In December 2019, a new type of Coronavirus (SARS-CoV-2) pneumonia (COVID-19) was reported in Wuhan and quickly spread worldwide. This study was designed to investigate the clinical symptoms of the COVID-19 patients.

    Methods

     In this retrospective study, we collected data of 132 COVID-19 dead patients. Demographic, epidemiological, and clinical data and laboratory test results were analyzed on days 1, 3, and 6 of admission.

    Results

    Most cases were in the 66-75 age group, 64.39% of which were males. Three days after admission, 55.3% of patients died. The most frequent clinical manifestations were dry cough (70.45%) and fever (54.54%), which increased during hospitalization. Diabetes and blood pressure were reported as the most prevalent underlying diseases. Lymphopenia and an increase in leucocyte number were observed in most patients. ESR (92.5%) and LDH (94.64%) levels were above normal. Furthermore, 42.85% and 44.73% of patients had elevated ALT and AST levels, respectively.

    Conclusion

     The results of this study revealed that males are more likely to be infected with SARS-CoV-19. Underlying diseases were common among patients and clinical and laboratory symptoms aggravated with a rise in hospitalization time.

    Keywords: Clinical features, COVID-19, Epidemiology, Iran, SARS-CoV-2
  • Ali Ashraf *, Maryam Shakiba, Alireza Sharifi Rad, Parstoo Pourali, Khadije Movaghari, Banafshe Bakhshi, Zainab Jahri
    Introduction

     Hypothermia is often present in trauma patients at the time of arrival to the hospital. Moderate hypothermia can be associated with an increased patient mortality rate. Early diagnosis and treatment can be effective in better patient outcomes.

    Materials and Methods

     In this analytic cross-sectional study, 325 trauma patients admitted to the emergency room (ER) of Poursina hospital were evaluated. The initial temperature was recorded as the tympanic temperature of the first 15 minutes of patients' arrival to the ER department by the infrared thermometer TM 80 manufactured by Healer Company. Other variables included: age, sex, IV fluid injected volume, method of patient transport, systolic blood pressure, and heart rate. After collecting data, analysis was done using SPSS software version 25.

    Results

     According to the findings of our study, 56 trauma patients out of 325 patients were hypothermic (17.2%). The average systolic blood pressure was lower in hypothermic patients and the average IV fluids volume injected into hypothermic trauma patients was higher than in other patients. 

    Conclusion

     Trauma patients are prone to hypothermia, although this complication does not have a high prevalence due to its harmful effects such as decreased systolic blood pressure, increased injected IV fluid volume, and increased hospitalization time, trauma patients should be monitored regularly for body temperature and necessary measures should be considered to eliminate hypothermia in trauma patients.

    Keywords: Hypothermia, Trauma, Body temperature
  • Alyeh Besharati, Alia Saberi, Samaneh Ghorbani Shirkouhi, Ali Ashraf, Hamidreza Hatamian, Habib Eslami Kenarsari, Sasan Andalib*
    Background

    Guillain-Barré Syndrome (GBS) is an autoimmune disease that may occur after infections. As Coronavirus Disease 2019 (COVID-19) may bring about GBS, it is important to assess the effect of the COVID-19 pandemic on this disease

    Objectives

    This study aimed to compare the distribution and characteristics of GBS during and before the COVID-19 pandemic in an academic referral hospital in the north of Iran.

    Materials & Methods

    This retrospective study assessed GBS distribution and characteristics during the COVID-19 pandemic period (from March 2020 to the end of February 2021) and before the pandemic (from March 2019 to the end of February 2020) on 5340 patients referred to the Neurology Ward of Poursina Hospital of Guilan Province, in Iran.

    Results

    There was no significant difference between GBS distribution during (0.03%) and before (0.04%) the COVID-19 pandemic (P=0.413). There were also no differences between the two periods regarding the gender (P=0.659) and age (P=0.417) of the patients. The most common subtype of GBS during the COVID-19 pandemic was Acute Motor and Sensory Axonal Neuropathy (AMSAN) (71.4%). In both periods, the most common type of treatment was intravenous administration of immune globulin. There was no significant difference between the two periods (P=0.838) regarding the patients’ treatment response.

    Conclusion

    The distribution of GBS, its subtypes, type of treatment, and response to treatment were not different between the two study periods.

    Keywords: COVID-19, Guillain-Barré syndrome, Autoimmune diseases
  • علی اشرف*، یلدا آشوریان، مرضیه حبیبی، فاطمه نجاتی فر، محمدصادق اسماعیلی دلشاد، صدیقه صمیمیان، سوگند وحیدی، مرتضی رهبر طارمسری، علی اکبر صمدانی
    هدف

    سرطان کولورکتال سومین سرطان شایع در ایران می باشد. مطالعات انجام شده در سراسر دنیا نشان داده اند که سن و جنس با سیر و پیش آگهی سرطان کولورکتال در ارتباط است. با توجه به این که شناخت فاکتورهای موثر بر سرطان کولورکتال باعث ارتقا سیستم غربالگری و انتخاب مدالیته های درمانی بهتری می شود و به دلیل عدم بررسی های این چنینی در ایران، در این مطالعه ارتباط درجه و مرحله بدخیمی با عوامل محیطی، جنسیت و سن بیماران مبتلا به سرطان کولورکتال مورد بررسی قرار گرفت.

    مواد و روش ها

     این مطالعه به صورت توصیفی- مقطعی بوده و گزارش پاتولوژی نمونه های بیماران مبتلا به سرطان کولورکتال بستری شده در طی سال های 1393 تا 1397 در بیمارستان پورسینای رشت از نظر سن، جنس، محل تومور و stage پاتولوژیک بیماران تحت ارزیابی قرار گرفت.

    یافته ها

     از 94 گزارش پاتولوژی مورد بررسی، تعداد مردان بیش تر از زنان و بیش ترین تعداد بیمار در گروه سنی 50-60 سال گزارش شد. درد شکم شایع ترین علامت بالینی هنگام تشخیص بود. بیش تر تومورها در رکتوم قرار داشتند. Stage III دارای بیش ترین فراوانی بود. مرحله های بالاتر با زن بودن ارتباط معنادار آماری داشت. ارتباط معناداری بین سن و مصرف سیگار و الکل با مرحله ی تومور کولورکتال نشان داده نشد. هم چنین درجه ی تومور با سن و جنس و سابقه ی مصرف سیگار و الکل بیماران ارتباط نداشت.

    نتیجه گیری

     در این مطالعه، بین جنس زن و مرحله های بالاتر سرطان ارتباط معناداری یافت شد. ولی ارتباطی بین سن و جنس و مصرف سیگار و الکل با درجه سرطان به دست نیامد. هم چنین بین سن و مصرف سیگار و الکل با مرحله سرطان نیز ارتباطی یافت نشد.

    کلید واژگان: مراحل سرطان، تکثیر سلولی، سرطان های کولون و راست روده، تشخیص زودهنگام سرطان
    Ali Ashraf*, Yalda Ashoorian, Marzieh Habibi, Fatemeh Nejatifar, MohammadSadegh Esmaeili Delshad, Sedigheh Samimian, Sogand Vahidi, Morteza Rahbar Taramsari, AliAkbar Samadani
    Introduction

    Colorectal cancer is the third most common cancer in Iran. Some studies have shown that age and sex are associated with the course and prognosis of colorectal cancer. Due to the fact that recognizing the factors affecting colorectal cancer improves the screening system and selects better treatment modalities, and due to the lack of such studies in Iran, in this study, the relationship between the degree and stage of malignancy with environmental factors, gender and age of patients was examined for colorectal cancer.

    Materials and Methods

    This is a descriptive cross-sectional study and the pathology report of samples of patients with colorectal cancer admitted during 1393-1397 in Poursina Hospital in Rasht (Iran) in terms of age, sex, tumor location and pathological stage of patients undergoing was evaluated.

    Results

    From 94 pathology reports, the number of men was more than women and the highest number of patients were reported in the age group of 50-60 years. Abdominal pain was the most common clinical symptom at diagnosis. Most tumors were located in the rectum. Stage III had the highest frequency. Higher stages were statistically significantly associated with being a woman. There was no significant relationship between age and smoking and alcohol consumption with colorectal tumor stage. Also, the degree of tumor was not related to age and sex and history of smoking and alcohol consumption of patients.

    Conclusion

    In this study, a significant relationship was found between the female gender and the higher stages of cancer. But there was no association between age and sex and smoking and alcohol consumption with the degree of cancer. Also, no relationship was found between age and smoking and alcohol consumption with the stage of cancer.

    Keywords: Neoplasm Staging, Cell Proliferation, Colorectal Neoplasms, Early Detection of Cancer
  • Alia Saberi, Sajjad Saadat*, Ali Ashraf, Tina Nabatchi Ahmadi, Farzin Bagheri Sheykhangafshe, Hamidreza Hatamian, Marjan Entezari
    Background

    Medical students, as part of the healthcare team, are directly exposed to challenging conditions during the COVID-19 epidemic. This study investigated COVID-19 anxiety, burnout, and academic achievement in stagers and interns of Guilan University of Medical Sciences.

    Materials & Methods

    The present analytical cross-sectional study was conducted on medical students and interns studying at Guilan University of Medical Sciences in the 2020-2021 academic year. Of whom, 150 students participated in this study. Corona Disease Anxiety Scale (CDAS) and Maslach Burnout Inventory-Student Survey (MBI-SS) were used to measure anxiety and academic burnout of the students, respectively. Measuring students’ academic achievement was based on Grade Point Average (GPA). Data analysis was performed using chi-square, Mann-Whitney U test, and partial Spearman correlation Coefficient.

    Results

    The participation rate in this study was 92%. The results showed that 6.5% of students had high anxiety, 18.8% reported high academic burnout, and 79% reported the average level of burnout score. Also, the participants’ GPA was 16.76±1.30. The academic burnout score was significantly higher in male students than female ones (t=-2.01; P=0.04). The GPA was significantly higher in students under 24 years old than in older students (t=4.71; P=0.01). The partial correlation coefficient adjusted for sex showed a positive and significant correlation between CDAS and MBI-SS (r=0.346; P<0.001).

    Conclusion

    The present study results showed that medical stagers and intern students had high academic burnout during the COVID-19 epidemic, and there was a weak and direct correlation between academic burnout and COVID-19 anxiety. Accordingly, to reduce the consequences of the COVID-19 epidemic, appropriate therapeutic and educational interventions should be provided to empower stagers and intern students.

    Keywords: COVID-19, Anxiety, burnout, Academic achievement, Medical students
  • Sedigheh Samimian, Sadra Ashrafi, Tahereh Khaleghdoost Mohammadi ∗, MohammadReza Yeganeh, AliAshraf, Hamideh Hakimi, Maryam Dehghani
    Introduction

    The recommended position for measuring Intra-Abdominal Pressure (IAP) is the supine position.However, patients put in this position are prone to Ventilator-associated pneumonia. This study was done toevaluate the relationship between bed head angle and IAP measurements of intubated patients in the intensivecare unit.

    Methods

    In this clinical trial, seventy-six critically ill patients under mechanical ventilation were en-rolled. IAP measurement was performed every 8 hours for 24 hours using the KORN method in three differentdegrees of the head of bed (HOB) elevation (0◦, 15◦, and 30◦). Bland-Altman analysis was performed to identifythe bias and limits of agreement among the three HOBs. According to World Society of the Abdominal Com-partment Syndrome (WSACS), we can consider two IAP techniques equivalent if a bias of <1 mmHg and limitsof agreement of - 4 to +4 were found between them. Data were analyzed using SPSS statistical software (v. 19),and the significance level was considered as 0.05.

    Results

    The prevalence of intra-abdominal hypertension was18.42%. Mean ± standard deviation (SD) of IAP were 8.44 ± 4.02 mmHg for HOB angle 0◦, 9.58 ± 4.52 for HOBangle 15◦, and 11.10 ± 4.73 for HOB angle 30o (p = 0.0001). The IAP measurement bias between HOB angle 0◦andHOB angle 15◦was 1.13 mmHg. This bias was 2.66 mmHg between HOB angle 0◦and HOB angle 30◦.

    Conclusion:

     Elevation of HOB angle from 0 to 30 degree significantly increases IAP. It seems that the measurement ofIAP at HOB angle 15◦was more reliable than 30◦.

    Keywords: Pressure, Intra-abdominal Hypertension, Head of Bed, Critical care, Compartment syndrome, Supine Position
  • Abbas Sedighinejad, Hossein Khoshrang, Mohammad Haghighi, Ali Ashraf, Mostafa Saeedinia *, Gelareh Biazar, Zahra Atrkarroushan, Mahdi Ajdadi
    Background

     Coronavirus disease 2019 (COVID-19) as an alarming attack broke out in China and spread rapidly worldwide.

    Objectives

     Based on a theory indicating the correlation between some viral diseases and blood types, we investigated the relationship between blood groups and coronavirus infection risk in Guilan Province, Iran.

    Methods

     Retrospectively, all the files of the admitted patients with suspected COVID-19, in peak conditions of the disease between March 1 and May 30, 2020, were reviewed using the Census method. The required data, including epidemiological and clinical information and outcomes, were obtained from electronic records.

    Results

     A total of 249 cases were analyzed, of whom 109 were collected from governmental centers, and the rest were collected from private hospitals. The most common co-morbidity was diabetes with 71 (37.6%) cases and the main symptom at the admission time was dyspnea with 170 (24.5%) cases. Of the total patients, 155 (62.2%) were discharged, and the rest died. The most common blood group among our patients was O Rh-positive with 91 (36.5%) cases. No meaningful correlation was found between outcomes and blood groups in terms of ABO types (P = 0.89) or Rh factor (P = 0.456). The Rh-positive proportion was significantly higher in the COVID-19 cases than in the general population (P = 0.038).

    Conclusions

     We found that the Rh-positive proportion was significantly higher in the COVID-19 cases than in the healthy individuals. However, no correlation was observed between the groups regarding ABO typing.

    Keywords: Association, COVID-19, ABO-Rh Blood Groups
  • Sepideh Paybast, Ali Ashraf*, Hakimeh Sarshad, Maryam Shakiba, Yasser Moadabi
    Introduction

    Currently, the most available treatment for acute ischemic stroke (AIS) is thrombolytic therapy with recombinant tissue plasminogen activator (r-TPA). A challenge in r-TPA therapy is the prediction of recovery in each case.

    Objective

    The aim was to find a possible relationship between the cerebral oximetry indexes and the clinical outcome of r-TPA therapy to assess the cerebral oximetry as a non-invasive monitoring agent for therapy.

    Methods

    The inclusion criteria were all patients with AIS who received r-TPA. The neurologic status was evaluated based on the national institutes of health stroke scale (NIHSS) score at arrival, and after a period of 24 hours. In addition, the levels of brain oxygenation in both hemispheres were measured before and continuously over the first 24 hours after r-TPA injection, using an oximetric sensor in the frontal lobes. The clinical success was defined as a 4-point improvement from the baseline NIHSS.

    Results

    Total 44 patients with the mean age of 58.2 ± 2.18 years were enrolled, of whom 68.18% were male. Twenty-eight patients remained clinically unimproved and 16 patients were improved. A significant difference was found in the mean surface area under the brain oximetric curve in the 24 hour, in the affected hemisphere in the improved group, compared to the unimproved group (P = 0.007). There was a significant difference between the mean increase in brain oxygenation within 24 hours in the improved and unimproved groups (P = 0.002).

    Conclusion

    It is likely that, The cerebral oximetry could contribute to predict the likelihood of r-TPA prognosis in patients with AIS.

    Keywords: Spectroscopy, Near-Infrared, Stroke, Oximetry, Tissue Plasminogen Activator, Outcome
  • زینب رحمتی *، بهرام یوسفی، علی اشرف
    این پژوهش با هدف بررسی تاثیر نوگرایی مصرف کنندگان بر سبک های خرید آنان انجام شده است. در این مطالعه، اثر نوگرایی مصرف کنندگان (احساسی و شناختی) بر سبک های خرید آنان بررسی شده است. روش پژوهش، توصیفی- پیمایشی بود و جامعه آماری آن، دانشجویان دانشگاه رازی کرمانشاه بودند. نمونه آماری پژوهش با استفاده از روش نمونه گیری تصادفی متناسب با حجم جامعه انتخاب شد. در پژوهش حاضر، برای گردآوری داده ها از روش میدانی استفاده شد؛ بدین صورت که براساس اختصاص بهینه، تعداد 325 پرسش نامه بین دانشجویان توزیع شد که تعداد 301 پرسش نامه صحیح برگشت داده شد که همین تعداد به عنوان نمونه آماری پژوهش درنظر گرفته شد. روایی پرسش نامه ها به تایید 15 نفر از اساتید متخصص در حوزه مدیریت ورزشی رسیدوپایایی آن هابااستفاده آلفای کرونباخ محاسبه شد که مقدار آن برای پرسش نامه نوگرایی0/84 = α و برای پرسش نامه سبک های خرید 0/80 = α بود که نشان دهنده پایایی قابل قبول مقیاس ها بود. برای تجزیه وتحلیل داده ها مدل معادلات ساختاری در نرم افزار لیزرل به کار گرفته شد. یافته های آزمون مدل پژوهش نشان داد که برازش مدل با داده ها مناسب بود و ضریب تاثیر دو عامل نوگرایی شناختی بر سبک های خریدآگاهی از کیفیت (0/63)، آگاهی از قیمت (0/67) و سردرگمی (0/60)و نوگرایی احساسی بر سبک های خرید مدگرایی (0/79)، عادت گرایی (0/78)، آگاهی از برند (0/76)، صحه گذاری (0/73)، بی برنامگی (64/0) و سرگرمی (0/63) معنا دار بود. نتایج نشان داد که نوگرایی بر هر نه سبک خرید اثرگذار بود. این یافته ها به بازاریابان ورزشی کمک می کنند تا بتوانند برای هدف قراردادن گروه یا بخش خاصی از مصرف کنندگان خود، رویکرد کارآمدتری را اتخاذ کنند.
    کلید واژگان: صحه گذاری، نوگرایی احساسی، نوگرایی شناختی
    Bahram Yoosefy, Zeinab Rahmati *, Ali Ashraf
    The aim of this research was to examine the effect of consumer innovativeness (emotion and cognitive) on shopping styles. This is a descriptive - survey and statistical society type of study. The participants were students of Razi University in Kermanshah. The statistical sample of the research was chosen according to the random-stratified sampling method. The field method was chosen for data collection. On the basis of optimal allocation, 325 questionnaires were distributed among the students and a total of 301 questionnaires were returned correctly and were chosen as the sample. The validity of the questionnaires was confirmed by 15 experts in the field of sports management and their reliability was calculated using the Cronbach's alpha. The value of the questionnaires such as the modernization questionnaire (α = 0.84) and the shopping style questionnaire   (α = 0.80) were calculated. These values showed the reliability of the scales. For data analysis, structural equation modeling was done using the LISREL software.Finally, the results of the research showed that fitting of the model with the data was appropriate. Also, the coefficient of influence of the two factors of cognitive innovativeness on purchasing styles: "quality awareness (0.63), cost awareness (0.67) and confusion (0.60)" and emotional innovativeness on purchasing styles, "fashion-oriented (0.79), habit-oriented (0.78), brand awareness (0.76), inurement (0.73), disorganization (0.64) and entertainment (0.63)" was meaningful. The results showed that innovativeness was effective on nine shopping styles. These findings enable sports marketers to adopt a more effective approach to targeting a particular group of users.
    Keywords: Inurement, Emotional innovativeness, Cognitive innovativeness
  • Siamak Rimaz, Ali Ashraf, Shideh Marzban, Mohammad Haghighi, Seyyed Mahdi Zia Ziabari, Gelareh Biazar *, Sheyda Rimaz, Samad Omidi
    Background
    Myocardial dysfunction is frequently described as an underlying cause of mortality in traumatic brain injury (TBI) known as brain-cardiac link. However the impact on prognosis of a disease remains uncertain.
    Objectives
    The current study aimed at investigating the correlation between TBI and cardiac troponin I (cTnI) rise and in-hospital mortality rate among patients with TBI.
    Methods
    In the current prospective study TBI patients with abbreviated injury scale score (AIS) > 3 and Glasgow coma scale (GCS) score ≤ 8 with cTnI measurement within the first 24 hours of admission were evaluated. Chi-square, Kruskal-Wallis, Mann-Whitney U and Logistic Regression tests were used for data analysis.
    Results
    A total of 166 eligible patients were studied .The mean age of the cases was 37.64 ± 17.21 years, largely under 65 (93.4%) and male (86.7%).The most common injuries were cerebral contusion (35.1%), while motor vehicle crash (MVC) was the most common cause of injuries (83.73%); 59 % of the patients showed detectable cTnI concentrations within 24 hours of admission; 65.7% of the patients expired; they showed higher levels of cTnI compared to survivors that showed lower levels, 0.148 ± 0.074 vs 0.057 ± 0.055, respectively (P < 0.001). Moreover, a significant association was observed between mortality rate and lower admission GCS 3.49 ± 1.08 vs 6.79 ± 1.66, respectively (P < 0.001).
    Conclusions
    Increased cTnI levels could be a predictor of mortality among patients with TBI. Its measurement and investigation for therapeutic strategies could lead to better management of these cases.
    Keywords: Cardiac Troponin I, Traumatic Brain Injury, Mortality
  • مهران فلک ناز، علی اعلمی*، عاطفه صبوری، دانیال کهریزی، علی اشرف

    خشک سالی و آثار ناشی از آن مهم ترین و رایج ترین تنش محیطی است که تولیدات کشاورزی را در جهان با محدودیت روبه رو ساخته است. یکی از راه بردهای مفید اصلاح گیاهان زراعی برای مقاومت به خشکی، حفظ و بهره گیری از تنوع موجود ژرم پلاسم آن ها می باشد. به منظور شناسایی منابع مقاومت به خشکی، 125ژنوتیپ گندم نیای آژیلوپس تائوشی در قالب طرح آگمنت با سه تکرار و تحت دو شرایط بدون تنش (آبیاری تکمیلی در سه مرحله ساقه دهی، گلدهی و پرشدن دانه) و تنش خشکی (بدون آبیاری تکمیلی) کشت و بر اساس شاخص های تحمل به خشکی مورد ارزیابی قرار گرفتند. مطالعه همبستگی عملکرد با شاخص های تحمل نشان داد که شاخص های میانگین حسابی (MP)، میانگین هندسی (GMP)، تحمل به تنش (STI) و تحمل (TOL) برای شناسایی ژنوتیپ های با عملکرد بالا در هر دو شرایط تنش و بدون تنش خشکی مناسب بودند. بر اساس این شاخص ها،به ترتیب ژنوتیپ های شماره 55، 50، 58 و 65 متحمل ترین ژنوتیپ ها و ژنوتیپ های شماره 45، 34، 3 و 9 حساس ترین ژنوتیپ ها تعیین شدند. گروه بندی ژنوتیپ ها بر مبنای شاخص های تحمل با استفاده از تجزیه خوشه ایبه روش متوسط فاصله بین گروه ها (UPGMA)، ژنوتیپ ها را در هفت گروه مختلف دسته بندیکرد. ژنوتیپ های شماره50،55، 58 و 65 کهدارایبیش ترین مقادیر برایاین شاخص ها بودند، در دو گروه سه و پنجقرار گرفتند. نتایج تحلیل های آماری مختلف در این تحقیق نشان داد که دو ژنوتیپ شماره 50 و 55 به عنوان متحمل ترین ژنوتیپ ها بودند و می توانند به عنوان منابع ژنتیکی مناسب در برنامه های به نژادی گندم برای تحمل به خشکی مورد توجه قرار گیرند.

    کلید واژگان: تجزیه خوشه ای، تنش خشکی، ژرم پلاسم، عملکرد دانه
    Mehran Falaknaz, Ali Aalami *, Atefeh Sabouri, Danial Kahrizi, Ali Ashraf

    The drought and its effect are the most important and common environmental stress that has limited agricultural production in the world. One of the useful strategies of crop breeding for drought resistance is maintaining and exploiting the diversity of their germplasms. To identify drought tolerant sources, 125 Aegilops tauschii genotypes in an augmented designwith three replications under twocontrol (supplementary irrigation in three stages of jointing, flowering and seed filling) and drought stress (without supplementary irrigation) conditions were cultivated and evaluated based on tolerance indices. Correlation coefficients between yield and tolerance indices showed that the indices ofmean productivity (MP), geometric mean productivity(GMP), stress tolerance index(STI) and tolerance index (TOL) were suitable for identifying high yielding genotypes under both stress and non-stress conditions. Based on these indices, genotypes 50, 55, 58 and 65 were identified as the most tolerant genotypes and genotypes 45, 34, 3 and 9 as the most sensitive genotypes. Cluster analysis based on tolerance indices using between-group average method (UPGMA) classified the studied genotypes into seven different groups. Genotypes number 50, 55, 58, and 65, with the highest values for above mentioned indices, were placed in two groups three and five. Finally, according to the results of different analyzes, genotypes number 50 and 55 were identified as the most tolerant genotypes, which could be considered as suitable genetic sources in wheat breeding programs for drought tolerance.

    Keywords: Cluster analysis, Drought stress, Germplasm, Grain yield
  • Ali Ashraf, Zoheir Reihanian, Jafar Hoseinzadeh*, Omid Mo'men, Roshanak Sanjabi, Maryam Shakiba
    Background and Aim
    Pain is an experience often caused by tissue damage and is proportional to the severity of the injury. The role of underlying factors in severity of the pain such as prehospital factors have been discussed in some investigations. The current study aimed to assess the effect of different parameters on pain severity in patients with trauma. Methods and Materials/Patients: The current descriptive, cross-sectional study was conducted fully conscious 270 fully patients with trauma admitted to Poursina Hospital in Rast, Guilan, Iran, in 2016. They were assessed in terms of demographic and pre-hospital factors as well as mechanism and severity of trauma based on verbal rating scale.
    Results
    Linear regression analysis demonstrated that among various factors like age, sex, level of education, opium dependence, vehicle type, ventilation, blood pressure, pulse rate, mechanism of trauma, and type of trauma, the highest severity of pain was pertaining to the type of trauma such as multiple trauma and large bone fracture with mean scores of 9.26 and 9.13, respectively. It also revealed that among these parameters, mechanism of trauma, type of trauma, transfer time, type of vehicle, and pulse rate were significantly associated with the severity of the pain.
    Conclusion
    The current study showed that increasing the quality of vehicle, decreasing the transfer time, and paying more attention to hemodynamic factors such as pulse rate, blood pressure, use of analgesic agents, and immobilization of damaged tissue can diminish the severity of pain in patients with trauma.
    Keywords: Severity, Pain, Trauma, Prehospital
  • مریم رجب پور نیکفام، عاطفه قنبری خانقاه *، طاهره خالق دوست محمدی، احسان کاظم نژاد لیلی، علی اشرف
    مقدمه
    شایعترین تشخیص نورولوژیک در میان بیماران بستری در بخش های مراقبت ویژه، دلیریوم می باشد. میزان شیوع دلیریوم بالا و با عوارض فراوانی همراه است.
    هدف
    هدف این مطالعه تعیین عوامل پیش بینی کننده بروز دلیریوم در بیماران بستری در بخش های مراقبت ویژه می باشد.
    روش کار
    این مطالعه یک پژوهش توصیفی- تحلیلی است. جامعه پژوهش شامل کلیه بیمارانی بود. به مدت سه ماه در سال 1392 در بخش های مراقبت ویژه (اعصاب، جنرال و تروما) در یکی از مراکز آموزشی و درمانی شهر رشت بستری شده و قبل از بستری شدن علایم و نشانه های دلیریوم را نداشته اند. جهت انتخاب نمونه ها بدون محدودیت سنی و با حداقل گذشت 24 ساعت از زمان پذیرش در بخش مراقبت ویژه (ICU)، با و بدون تهویه مکانیکی، دارای توانایی بینایی و شنوایی، دانستن زبان فارسی و شرط هوشیار یا نیمه هوشیار بودن، عدم دریافت بلوک کننده های عصبی- عضلانی، کما، سابقه آسیبهای عصبی شدید، نارسایی مزمن کلیوی، سوء مصرف الکل و مواد مخدر وارد پژوهش شدند نمونه ها به صورت تدریجی انتخاب شدند. حجم 81 نفر برآورد گردید. ابزارهای مورد استفاده در این پژوهش شامل Richmond Agitation Sedation Scale RASS)) و Confusion Assessment Method for the Intensive Care Unit (CAM–ICU) بود. ابزار RASS ابزاری استاندارد می باشد و جهت بررسی سطح بی قراری و تسکین بیماران بستری در ICU معتبر شناخته شده است. ابزار CAM-ICU نیز 4 ویژگی اصلی دلیریوم یعنی تغییر حاد یا سیر نوسانی وضعیت ذهنی بیمار، عدم تمرکز، اختلال سطح هوشیاری و تفکر سازماندهی نشده، را مورد بررسی قرار می دهد. بخش اول پرسشنامه مشخصات دموگرافیک بیماران شامل: سن، جنس، شاخص بیماری های همراه چارلسون، امتیاز فیزیولوژی حاد Acute Physicology Score (APS) در سه دامنه 9 – 0، 14 – 10 و ≥ 15 شمارش گلبولهای سفید خون، بیلی روبین توتال سرم، تعداد روزهای تهویه مکانیکی، تعداد روزهای بستری در ICU و بیمارستان بود. شاخص بیماری های همراه چارلسون شامل 19 شرایط بیماری است که به بیمار براساس تاثیر بالقوه آن بر میزان مرگ و میر امتیاز داده می شود. امتیاز فیزیولوژی حاد (APS) نیز بزرگترین قسمت امتیازAPATCH (ارزیابی حاد فیزیولوژی و ارزیابی مزمن سلامتی) می باشد که از 13 نوع اندازه گیری بالینی بدست می آید که 24 ساعت پس از پذیرش بیمار در ICU انجام می گیرد و کسب امتیاز بالاتر در ان وخیم تر بودن وضعیت فیزیکی بیمار را نشان می دهد. بخش دوم بررسی بروز دلیریوم بود که در ابتدا بیمار توسط مقیاس RASS از نظر سطح هوشیاری بررسی می شد. این ابزار شامل 10 گویه و هر یک معرف یکی از سطوح هوشیاری است. برای تعیین امتیازRASS ابتدا بدون هیچ تعاملی، فقط بیمار مشاهده شد و در صورت هوشیاری امتیاز (0 تا 4+) برای او درنظر گرفته شده . در صورت عدم هوشیاری بیمار نام وی را با صدای بلند صدا زده و از او درخواست می شد که به پژوهشگر نگاه کند. اگر بیمار به صدا واکنش نشان داد، امتیاز مناسب (1- تا 3-) در صورت عدم واکنش، شانه بیمار تکان داده می شد. اگر هیچ واکنشی نداشت به شدت جناغ وی را فشرده و امتیاز مناسب (4- تا 5-) نمونه ها در صورت عدم ابتلا به اختلال سطح هوشیاری بر اساس مقیاس RASS با مقیاس CAM-ICU از نظر بروز دلیریوم بررسی شدند که بررسی با این ابزار حدود 5-3 دقیقه طول می کشید. اطلاعات جمع آوری شده با استفاده از آمار توصیفی و تحلیلی (آزمون فیشر و مجذور کای) تجزیه و تحلیل شدند و جهت آنالیز چندگانه عوامل مرتبط با دلیریوم از مدل رگرسیون لجستیک به روش Backward استفاده گردید که در این مدل احتمال معنی داری با 05/0 >P و احتمال خروج از مدل با 1/0 >P در نظر گرفته شد.
    نتایج
    نتایج بیانگر آن بود که 2/64 درصد واحدهای مورد پژوهش مرد و اکثر آنها (1/48 %) در بخش جنرال بستری بودند . اکثریت نمونه ها (4/49 %) از لحاظ امتیاز فیزیولوژی حاد (APS) نمره 9 - 0 را کسب نمودند. در بررسی وضعیت بیماری های همراه چارلسون نیز بیشتر نمونه ها (6/29 %) امتیاز بین 2- 1 داشتند. میانگین سنی واحدهای مورد پژوهش 33/21 ± 95/50 سال، حداکثر روزهای لوله گذاری در تراشه 146 روز، بستری در ICU، 147 روز و بستری در بیمارستان 150 روز بود. همچنین میزان حداکثر بیلی روبین توتال 4/2 میلی گرم در دسی لیتر و بیشترین مقدار تعداد گلبول های سفید خون 2/29 هزار در میلی لیتر بود. بروز دلیریوم با ابزار CAM-ICU در 2/27 درصد مشاهده شد. توزیع دلیریوم بر حسب متغیرهای کیفی جنس، بخش و امتیاز چارلسون معنی دار نبوده اما بر حسب امتیاز APS معنی دار بوده است (048/0P=). همچنین توزیع دلیریوم بر حسب متغیر کمی سن معنی دار بوده (006/0P=)، ولی بر حسب تعداد روزهای تهویه مکانیکی، بستری در بیمارستان و بستری در ICU، بیلی روبین توتال و تعداد گلبولهای سفید از لحاظ آماری معنی دار نبوده است. بر اساس مدل رگرسیون لجستیک، متغیرهای سن، جنس، بخش، تعداد روزهای تحت لوله گذاری در تراشه، روزهای بستری در ICU و بیمارستان، بیلی روبین توتال، تعداد گلبولهای سفید و شاخص چارلسون عوامل پیش بینی کننده دلیریوم نبودند و تنها APS (با در نظر گرفتن محدوده 9 – 0 امتیاز به عنوان گروه مرجع) در دو دامنه امتیاز 14 – 10 (038/0P <) و 15 ≤ (043/0 >P) به عنوان عامل مرتبط پیش بینی کننده دلیریوم شناخته شدند، به طوریکه افراد دارای نمره 14 - 10APS= (3/3OR= و 71/10 – 03/1 : 95% CI) و ≥ 15 APS ≥ (2/4 OR =و7/16 – 08/1 : 95%CI) نسبت به افراد با 9 – 0 APS = از شانس نسبی دلیریوم بیشتری برخوردار بودند.
    نتیجه گیری
    افراد با امتیاز APS بالاتر نسبت به افراد با امتیاز کمتر، بیشتر در معرض ابتلا به دلیریوم هستند
    کلید واژگان: دلیریوم، بخش مراقبت ویژه، بیماران بستری
    Maryam Rajabpour Nikfam, Atefeh Ghanbari Khanghah*, Tahereh Khaleghdoost Mohammadi, Ehsan Kazemnezhad Leili, Ali Ashraf
    Introduction
    Delirium is the most common neurological diagnosis among patients in intensive care units. The prevalence of delirium in the ICU patients is high and this is associated with many complications. Thus, by assessment and identifying predictive factors of delirium, its incidence can largely be prevented in intensive care units.
    Objective
    This study aims to determine predictive factors of delirium incidence in patients hospitalized in intensive care units.
    Methods
    This study is a descriptive-analytic study which included all patients admitted to intensive care units (neurology, general and trauma) in one of the training centers, Rasht for three months in 2013 without any symptoms and signs of delirium before hospitalization. There was no age limit for selection of samples. At least 24 hours after admission to ICU, with and without mechanical ventilation, ability to see and hear, Persian language, conscious or semi-conscious, not receiving neuromuscular blockers, coma, history of severe nerve damage (such as acute stroke, dementia, aphasia), chronic renal failure, alcohol abuse and drug abuse were the study inclusion criteria. Patients who used painkiller and sedatives during the study were excluded. Thus, samples were selected gradually considering the inclusion criteria. Based on the preliminary results with 20 samples, the study sample size was estimated 81. The tools used in this study were Richmond Agitation Sedation Scale (RASS) and Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). RASS is the standard tool to assess the level of restlessness and sedation in ICU patients. CAM-ICU examines four main characteristics of delirium; acute change or fluctuations in mental status, lack of concentration, disturbance of consciousness and unorganized thinking.
    The first part consisted of demographic characteristics including age, sex, Charleson comorbidity index, Acute Physiology Score (APS) in three ranges of 0-9, 10-14-and ≥15, white blood cell count, serum total bilirubin, days of mechanical ventilation, and days of ICU stay and hospitalization. Charlson comorbidity index had 19 conditions in which the patient is scored based on its potential impact on mortality rate. APS is the biggest part of APATCH (Acute Physiology and Chronic Health Evaluation), obtained from 13 clinical evaluations performed 24 hours after ICU admission in which higher scores is indicative of worsening patient's physical condition. The second part consisted of examining the incidence of delirium in which patients were assessed by RASS in terms of level of consciousness. This tool consisted of 10 items, each representing one level of consciousness (of Combative to Unarousable). To determine RASS, without any interaction, the patient was only observed and if conscious, she was scored 0 to . If the patient was unconscious, his/her name was called loudly and asked to look at the researcher. If the patient responded to call, appropriate score (1-3) was assigned. If there was no response, the patient's shoulder was shaken. If no response was observed, his/her sternum was strongly squeezed and appropriate score (4-5) was given. In case of no consciousness level disorder based on RASS, the subjects were assessed by CAM-ICU for examining delirium which took about 3-5 minutes.
    The collected data were analyzed using descriptive and analytical statistics (Fisher and chi-square). For multivariate analysis of the associated factors with delirium, Backward Logistic Regression model was used. P
    Results
    64.2% of the subjects were male and most of them (48.1%) were hospitalized in the general ward. The majority of samples (49.4%) scored 0-9 in terms of APS. Charlson comorbidity index also showed most cases (29.6%) with 1-2 scores. The mean and SD of patients were 50.95 ± 21.33 years, the maximum tracheal intubation days was 146 days. The maximum duration of ICU stay was 147 days and 150 days in the hospital. Furthermore, the maximum total bilirubin was 4.2 mg dl and the highest number of white blood cells was 29.2000 mg dl. Delirium was observed in 27.2% of samples using CAM-ICU. Delirium distribution was not significant based on qualitative variables; sex, ward and Charlson score whereas APS score which was significant (p=0.048). Distribution of delirium was significant in terms of age (P=0.06). However, it was not statistically significant in terms of the number of mechanical ventilation days, hospitalization and ICU stay, total bilirubin and white blood cell count.
    Based on logistic regression model, age, sex, days of tracheal intubation, ICU and hospitalization days, total bilirubin, white blood cell count, and Charlson index were not predictors of delirium. Only APS (considering the range of 0-9 scores as the reference) in two ranges of 10-14 (P
    Conclusion
    Patients with APS points higher than those with lower scores are more likely to develop delirium.
    Keywords: Delirium, Intensive Care Units, Inpatients
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سامانه نویسندگان
  • دکتر علی اشرف جعفری
    دکتر علی اشرف جعفری
    استاد اصلاح نباتات، موسسه تحقیقات جنگلها و مراتع کشور، ، ایران
  • دکتر علی اشرف مهرابی
    دکتر علی اشرف مهرابی
    دانشیار دانشکده علوم کشاورزی، دانشگاه شاهد تهران
  • علی اشرف عیوضی
    علی اشرف عیوضی
    استاد بیولوژی و کنترل ناقلین بیماری ها، دانشگاه علوم پزشکی ایلام، ایلام، ایران
  • سید علی اشرف صدرالدینی
    سید علی اشرف صدرالدینی
    استاد آبیاری و زهکشی، گروه مهندسی آب، دانشگاه تبریز، تبریز، ایران
  • دکتر محمدعلی اشرف گنجوئی
    دکتر محمدعلی اشرف گنجوئی
    دانشجوی دکتری معماری، دانشکده معماری و شهرسازی، دانشگاه هنر اصفهان، اصفهان، ایران
  • علی اشرف سلطانی طولارود
    علی اشرف سلطانی طولارود
    (1391) دکتری علوم و مهندسی خاک گرایش بیولوژی و بیوتکنولوژی خاک، دانشگاه تهران
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