bahram pourseyedi

Hemorrhoids can be managed by means of several therapeutic options. Regarding this, it is of fundamental importance to identify the hemorrhoidectomy method with fewer complications (e.g., bleeding, pain, and postoperative infections) or beneficial outcomes (e.g., accelerated speed of wound healing and resumption of normal life activities). Such knowledge can play a significant role in the advancement of medical and educational goals. Therefore, the present study was conducted to compare the clinical results of Milligan-Morgan surgery and hemorapy device in the treatment of patients with hemorrhoids.

This prospective study was conducted on 60 patients aged over 20 years with hemorrhoids referring to Bahonar and Afzalipour hospitals of Kerman, Iran, and diagnosed to need surgery by a surgical specialist. The study population was selected using a simple randomization method and then allocated into two groups of A and B, regardless of gender. Group A was operated by open or Milligan-Morgan technique, while group B was subjected to the hemorapy method. After the surgery, the patients’ data were recorded in specific forms and analyzed by SPSS software (version 21).

Out of 60 patients with hemorrhoids, 37 (64%) cases were male. Regarding the severity of hemorrhoids, 19 (32%) and 41 (68%) patients had fourth-degree and third-degree hemorrhoids, respectively. The mean age of the patients was 35.86±12.84 years. Four weeks after the surgery, the mean pain scores of the patients in the Milligan-Morgan and hemorapy groups were 3.67±1.84 and 1.67±1.35, respectively, showing a statistically significant difference (P=0.001). However, 8 weeks post-surgery, no pain, bleeding events, urinary retention, or incontinence were observed in the patients, except for anal stenosis in two patients treated with the Milligan-Morgan method.

According to the results, the hemorapy method resulted in lower postoperative pain than the Milligan-Morgan method. In addition, the hemorapy technique was accompanied by considerably fewer complications, such as bleeding, urinary retention, gas incontinence, and stenosis, compared to the Milligan-Morgan method. Consequently, the hemorapy method can be recommended for hemorrhoidectomy.

There are various methods to treat hemorrhoids. It is very important to examine which hemorrhoidectomy has fewer complications and also faster recovery and return of the patient to normal life. The aim of this study was to compare the clinical outcomes of two methods, including Milligan-Morgan surgery and the hemorrhoid system in patients with hemorrhoids.
Methods and Materials: In this cross-sectional study, sixteen patients were randomly chosen from all patients with hemorrhoids referring to the clinics of Bahonar and Afzalipour hospitals who needed surgical diagnosis of the surgical specialist. Patients were classified into two groups regardless of gender. Group A was operated by open or Milligan- Morgan and group B was performed by the hemorapy method. After surgery, patients’ information was recorded in a checklist and analyzed by SPSS (version 21) software. 37 patients (64%) were male and 23 (36%) were female. 19 patients (32%) had hemorrhoid Fourth degree, and 41 patients (68%) had hemorrhoid Third-degree. The mean pain of patients after 8 weeks of surgery between the two groups was 1.12±0.57 in the Milligan-Morgan group and 0.55±0.47 in the hemorapy group, respectively. This difference was statistically significant. (pvalue=0.042). However, there were no bleeding events, urinary retention, and incontinence, and in 2 patients treated with the Milligan-Morgan method, it was observed that there was no anal stenosis in patients with hemorapy.
Discussion and The results showed that the postoperative pain was less in the hemorapy method than in the Milligan-Morgan method. Furtheremore, complications such as bleeding, urinary retention and gas incontinency and anal stenosis were much less than the MilliganMorgan method. This method is used for hemorrhoidectomy.

The aim of this study was to evaluate the effects of albumin correction and positive energy balance in the outcome of multiple trauma patients admitted to the intensive care unit.
This cross-sectional study was carried out on 196 patients suffering from multiple trauma admitted to ICU in Bahonar Hospital in Kerman in 2016. Patients were initially sampled to measure serum levels of albumin, then after correction of albumin, the levels of albumin were measured via vial and all data were collected and analyzed.
The mean of standard deviation for serum levels of albumin in patients under study was 3.6 ± 0.9% after admission and 3.45 ± 0.75 after correction. There was no significant relationship regarding albumin level (P value = 0.262).
The results of this study revealed that the degree of malnutrition of patients before admission can be a strong prognosis factor in predicting the rate of mortality of patients in intensive care unit. Moreover, the albumin serum can act as a predictive factor of the mortality of hospitalized patients due to trauma; of course, this needs further studies to be dedicated to.

Breast cancer is formed of a neoplastic component (epithelial) and a non-neoplastic component (stroma). Stromal- stromal and tumor- stromal interactions have been shown in the regulation of cancer cell growth, metastatic capacity and outcome of treatment. Tumor-associated macrophages (TAMs) are a component of tumor stroma reactionsand are considered as an important component of breast cancer tumor tissue which approximately form 50 % to 80 % of tumor tissue.In this study, the frequency of CD68 positive cells in association with other factors such as age, tumor size, ER, PR, Ki-67, Her2-neu receptors, stage and grade in invasive carcinoma tissues were morphologically and statistically evaluated. The frequency of CD68 was also discussed in relation to the number of involved lymph nodes.
A total of 50 invasive breast cancer patients with and without axillary lymph nodes involvement were studied. IHC staining for CD68 and Ki-67 markers was performed. For each tumor, 5 fields with different density of CD68 were counted under 400x by optical microscopy and the average of the five fields was taken as the percentage. Patients were divided into the two groups of low infiltration and high infiltration based on the percentage of CD68.By the same way, patients were divided into the two groups of low infiltration and high infiltration based on Ki67 percentage.
CD68 positive cells had significant correlation with ER negative and higher Ki67. No significant correlation was found between CD68 positive cells and the number of involved lymph nodes, age, size, HER2neu, PR, stage and grade.
It seems that the presence of CD68 -positive macrophages in invasive breast cancers and nearby lymph nodes is associated with a worse prognosis.

Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 is overexpressed in multiple types of cancer including breast cancer and is associated with resistance to treatment. The current study aimed at investigating the expression of SPHK1 in estrogen and progesterone receptors (ER, PR) negative in comparison to ER, and PR positive breast cancer and their normal controls, and also finding the relationship between SPHK1 expression and high body index (BMI) in the selected groups with breast cancer.
A total of 120 human breast cancer tissue specimens were analyzed for SPHK1 expression using quantitative real–time polymerase chain reaction (q RT-PCR) assay. Detection of hormonal status of breast cancer tissue samples was conducted by immunohistochemical assay.
The current study findings showed that the level of SPHK1expression in the breast cancer tissue was significantly higher in patients with estrogen and progesterone negative receptors, compared to the ones without them (P-value 25).
The current study showed that expression of SPHK1gene was higher in the patients with ER and PR negative breast cancer and high BMI, compared with other groups.

Myasthenia gravis is a neurological disorder characterized by muscle weakness. The role of thoracoscopic thymectomy in the treatment of this disease is controversial, but has some advantages that include less pain, shorter hospital stays, and better cosmetic results. After the introduction of video-assisted thoracoscopic surgery (VATS) thymectomy, there has been increased interest in the use of this technique for myasthenia gravis. We conducted a retrospective study to assess the safety and efficacy of VATS thymectomy in treatment of myasthenia gravis.Patients and The medical records of 50 patients who underwent VATS thymectomy for the treatment of myasthenia gravis between May 2005 and June 2010 in Afzalipour Hospital, (affiliated to Kerman Medical University of Sciences, Iran) were reviewed. The patients were examined for response to treatment; for patients who were not available for examination, data was obtained through telephone conversations. Forty-three of 50 patients were accessible. Of these, 34 were female and 16 were male, with a mean age of 34.8 years. The treatment responses were remission, 6 (16%); improvement, 30 (70%); and without change, 7 (16%). The total positive response to treatment was 84 percent. VATS thymectomy has been considered as a safe and effective treatment in myasthenia gravis and was associated with low mortality and morbidity. VATS thymectomy is recommended for the treatment of myasthenia gravis.