elham shahhosseini

Ovarian granulosa cell tumors (GCT) are rare tumors with a late recurrence and a good prognosis. The current study investigated the fertility and obstetrics situation, survival, and the factors influencing the mortality of patients with these uncommon ovarian neoplasms.

This is a retrospective study on ovarian GCT patients admitted to the Al-Zahra hospital oncology department, the tertiary referral hospital in Tabriz, between 2009 and 2022. Data were collected from medical records. Chi-square/Fisher exact tests and t tests were used to compare categorical and quantitative variables between the alive and dead patients, respectively. The Kaplan-Meier curve was used to present patients’ survival.

The study involved 65 patients with ovarian GCT. The presence of ovarian cysts statistically increased the survival of GCT patients (P=0.028). The advanced tumor stage (P=0.023), fast tumor growth (P=0.001), and tumor relapse (P=0.001) are significantly correlated with mortality in the affected patients. However, age and adjuvant chemotherapy were not associated with survival.

There was no evidence of increased survival with the use of adjuvant chemotherapy. Tumor staging is an important prognostic factor. Advanced stages were associated with inferior survival, and only prospective studies can ascertain their definite role.

Housing is the particular center of people’s activity and a part of Iranian society’s identity according to their social, economic, and cultural conditions. Socio-economic concerns have always been significant in residential complexes, but they are particularly vital in low-cost housing, such as Maskan-e-Mehr, because of the complex’s isolation from the city and the residents’ lack of familiarity. Therefore, social continuity is not formed, and people ignore improving their living conditions. This study aimed to evaluate the low-cost housing indicators and the influence of socio-economic factors on its models in Kerman, Iran, considering that because of real estate housing syndrome, socio-economic factors produce quantitative and qualitative indicators of low-cost housing. This case study was conducted using various information sources with qualitative and quantitative results, and the data were analyzed using ANP and AHP methods. The research objective was to provide a low-cost housing formation model considering economic-social factors. The results showed that the administrative bureaucracy sub-criteria are the most effective among the project’s components. The sub-criteria of weakness in the contract due to execution type, contract incompatibility, exclusivity in material supply, and transportation costs were placed in the following priorities.

Fibroids are solid ovarian tumors, usually originating from connective tissue, that vary in size; from the small size of small nodules on the ovarian surface to large neoplasms weighing several kilograms.

a 43-year-old married woman, nulli gravida, without any past medical history,
who complained of Amenorrhea in six past recent months, was referred to our academic hospital in Tabriz, Iran. According to the size of the abdomen, it was not possible to determine the exact size of the uterus by pelvic examination. The laboratory test was normal, and CA-125 was 79.6. In CTS scan, mild pericardial effusion, massive pleural effusion in the right lung, and a solid cystic mass without a sharp limit with size of 114╳91╳91 mm above the uterus that probably was originated from left adnexa was reported. In the right adnexa, a mural nodule cystic lesian with size of 46╳43 mm with a huge amount of abdominal fluid was revealed. According to the patient's symptoms, resend abdominal distension, pain, and Amenorrhea, and medical imaging after counseling with the patient, she was referred to Hemato-oncologists, and nine sessions of chemotherapy was performed and again referred to CT scan. According to the observations of CT scan and clinical examination, the patient underwent laparotomy and bilateral salpingo-oophorectomy and myomectomy was performed.
The frozen section result was included fibro-thecoma, Adeno fibroma cyst, and uterine Leiomyoma, and so was benign.

In cases of accompanying ovarian mass with ascites and pleural effusion, and abnormal uterine bleeding pattern, it is very important to think about benign ovarian mass differential diagnosis such as Fibrothecoma with Meigs syndrome after removal of the ovarian neoplasm, and there is a prompt resolution of both abdominal and pleural fluid.

As the world's sixth prevalent malignancy among women, the increased rate of mortality in ovarian cancer (OC)  patients is due to late diagnosis that causes a high rate of proliferation within the abdominal cavity. The sensitivity of screening and detection methods for the diagnosis of ovarian cancer in the early stages is insufficient. Considering the high rate of ovarian cancers resistance to most traditional treatments that cause the risk of disease recurrence and death, it is necessary to design new treatments and diagnostic methods. In this regard, nanoparticles and nanotechnology can be viable options for suppressing these limitations. One of the goals of nanotechnology is to improve the approaches of diagnosing, treating, or their combination (theranostics) in a variety of diseases including cancer. Au nanoparticles can simultaneously integrate therapeutic and imaging agents due to their special and extraordinary physicochemical properties and function as theranostic platforms. Next to their numerous distinct features, such as small size, surface impacts, quantum size, and electrical and optical effects, AuNPs proved to be relatively secure, stable, and require a simple preparation. Gold nanoparticles can be exerted as carriers for a more effective and targeted diagnostic and therapeutic agent delivery in the treatment of ovarian cancer. They can limit drug toxicity at tumor site and consequently reduce the toxicity of normal cells and tissues. Gold nanoparticles can be used as nano-theranostics agents and facilitate personalized medicine for a more efficient treatment of ovarian cancer by providing the simultaneous delivering of diagnostic and therapeutic agents.

Middle-Upper Eocene volcanic and volcano-sedimentary rocks of the Torud region have been formed by the sequences of basic-intermediate lavas, pyroclastic rocks, and sedimentary layers (e.g., siltstone, sandstone, and nummulite-bearing limestone) within a shallow marine basin. According to microscopic studies, the volcanic rocks of the region include basalt, basaltic andesite, trachyandesite, andesite, and dacite. These rocks have originated from the differential crystallization processes and occasionally calc-alkaline contamination geochemical properties. Generally, they contain olivine, clinopyroxene, and plagioclase ± amphibole minerals. Porphyritic to megaporphyritic textures with microlithic and flow matrixes are observed in these rocks. Studying the main and rare elements of these rocks indicates that reducing MgO content is accompanied by an increase in Al2O3, K2O, Na2O, and SiO2 and a decrease in Fe2O3 and CaO concentrations. These rocks are mainly enriched in LIL and LREE elements but depleted of HFS elements. The prominent features of these rocks are the presence of positive anomalies in the K, Sr, Rb, and Ba elements, the depletion of some samples of Nb and Ta, and their depletion of Ti and P. This result reveals the crustal contamination of the mantle mafic magma constructing these rocks. According to the geochemical data, magmatic pollution has not been an effective process in the formation of these rocks. In addition, the relatively higher levels of Cr, Ni, and MgO in the alkali basalts of the region indicate that these rocks are originated from partial melting (5 to 10%) of a spinel-garnet peridotite. Overall, they have no subduction-dependent rock characteristics and mainly represent characteristics of alkali basaltic magmas of the preliminary back-arc basin (BAB). These features, attributed to their calc-alkaline nature, represent the formation of these rocks in a tectonic back-arc setting in the Middle-Upper Eocene.

The area of study is located 120 Km north-east of Shahrood city. In terms of structure and geological classification, this area is located in the northern part of central Iran zone. Granitoids of Troud ranging from monzonite to granite. The main minerals of granitoids are quartz, plagioclase, and orthose. The accessory minerals are biotite, hornblende, sphene, and opaque minerals. Various textures of granular, graphic and prethite are observed in these rocks. Based on various diagrams of major and trace elements, this rock is I-type arc calk-alkaline, Meta to para-aluminous with continental origin form at subduction zone. All these characteristics, combined with low Al2O3/(FeO + MgO + TiO2) and (Na2O +K2O)/(FeO + MgO + TiO2) ratios and high Mg# values, suggest an origin through dehydration melting of alkaline mafic of lower crustal source rocks.

Asthma is a common respiratory disorder which often exacerbated during sleep. This study was done to determine sleep disorders among patients suffered from asthma. In this cross-sectional descriptive study، 95 asthmatic patients were selected using convenient sampling method. A questionnaire consisting of both demographic information and Global Sleep Assessment was employed to gather data. Results were analyzed using SPSS version 15. The prevalence of disorder differs from % 1/1 (sleep waking)، to %78 /9 (interruption in sleep maintenance). As there is a high prevalence of sleep disorders among asthmatic patients، early detection and treatment of this disease is recommended.