به جمع مشترکان مگیران بپیوندید!

تنها با پرداخت 70 هزارتومان حق اشتراک سالانه به متن مقالات دسترسی داشته باشید و 100 مقاله را بدون هزینه دیگری دریافت کنید.

برای پرداخت حق اشتراک اگر عضو هستید وارد شوید در غیر این صورت حساب کاربری جدید ایجاد کنید

عضویت

فهرست مطالب hedieh matloubi

  • Hedieh Matloubi, Mohammad Vodjgani, Abbass Ali Nasehi, Mohammad Hossein Niknam, Anoushirvan Kazemnejad, Eisa Salehi, Tahereh Aboufazeli, Zahra Gheflati
    Background
    Apart from genetic and environmental factors, activation of autoreactive mechanisms has been proposed to play a role in the pathogenesis of schizophrenia. In re-cent years, considerable work has been carried out to understand the role and contribution of the immune system in this disease.
    Objective
    To investigate the T cell response to phytohaemagglutinin (PHA) and determine the serum levels of anti-nuclear antibody (ANA), anti-cytoplasmic antibody (ACA), and circulating immune complexes (CIC) in schizophrenic patients.
    Methods
    A total of 30 drug-free schizophrenic patients and 42 healthy controls were enrolled in this study. T cell proliferation in response to PHA was measured using Methyl Thiazol Tetrazolium test. ANA and ACA were measured by indi-rect immunofluorescence. CIC concentration was determined using poly ethylene glycol precipitation assay.
    Results
    Mean PHA response was 1.96 ± 0.83 in patients and 3.72±1.39 in healthy controls (p < 0.001). ANA and CIC concentrations were not signifi-cantly different between two groups. In addition, ACA was detected only in patients.
    Conclusion
    Increased production of ACA together with lower T cell response to mito-gens in our patients provides evidence for the involvement of autoimmune mechanisms in the pathogenesis of schizophrenia.
  • Mohammad Vodjgani, Hedieh Matloubi, Abbas Ali Nasehi, Mohammad Hossein Niknam, Anoushirvan Kazemnejad, Eisa Salehi, Tahereh Aboufazeli, Zahra Gheflat
    Background
    Schizophrenia has been associated with altered immunity. Different studies regarding natural killer cell activity (NKA) in schizophrenic patients have shown inconsistent results.
    Objectives
    To evaluate NK cell activity in schizophrenic patients in comparison with healthy control individuals.
    Methods
    30 medication-free schizophrenic patients and 41 healthy sex، age and smoking status matched individuals were included in this study. NK cell activity of case and control subjects was measured by Methyl-Thiazol-Tetrazolium (MTT) test. Statistical analysis of the data was done using SPSS 11. 5 software.
    Results
    NK activity of patients and normal subjects had a mean of 36. 94 ± 26. 15 (Mean ± SD) and 22. 31 ± 17. 92، respectively. A significant increase in NK activity in schizophrenic patients compared to controls (P = 0. 011). Among patients، NK activity of smokers was significantly lower than that of non-smokers (P = 0. 02). Other demographic factors didn''t show any influence on NK activity.
    Conclusion
    The higher activity of NK cells in the schizophrenic patients as compared with the control population could explain the low incidence of cancer in these patients. Decreasing the effect of smoking on NK activity in the patients could be one of the responsible factors for the inconsistency in the results of different studies.
بدانید!
  • در این صفحه نام مورد نظر در اسامی نویسندگان مقالات جستجو می‌شود. ممکن است نتایج شامل مطالب نویسندگان هم نام و حتی در رشته‌های مختلف باشد.
  • همه مقالات ترجمه فارسی یا انگلیسی ندارند پس ممکن است مقالاتی باشند که نام نویسنده مورد نظر شما به صورت معادل فارسی یا انگلیسی آن درج شده باشد. در صفحه جستجوی پیشرفته می‌توانید همزمان نام فارسی و انگلیسی نویسنده را درج نمایید.
  • در صورتی که می‌خواهید جستجو را با شرایط متفاوت تکرار کنید به صفحه جستجوی پیشرفته مطالب نشریات مراجعه کنید.
درخواست پشتیبانی - گزارش اشکال