hosein khedmat

Metabolic disturbances and dyslipidemia are among the most important medical problems in human society. Their effects on the mortality of coronary heart disease (CHD) have lead to many investigations about them. An epidemiologic cross-sectional study was carried out on 10136 persons selected randomly in Tehran urban district 13 with a minimum age of 20 years and over. We measured fasting blood sugar, blood sugar 2 hours post 75 grams oral glucose, triglyceride, total cholesterol, LDL cholesterol, HDL cholesterol, alkaline phosphatase and TSH. Degree of physical activity was registered according to “LRC” classification and anthropometric data, Social condition, family history and smoking exactly delineated. Our patients were divided into two groups. Those who had normal lipid profile and those with dyslipidemia. The latter group was further divided into two subgroups. Primary (without any risk factor for dyslipidemia) and secondary (having one or more risk factors such as DM…). ANOVA, t test, and logistic were used to analyze the level of significance. A P value of 0.05 was adopted. of all patients, 9632cases (5619 female and 4013 male) had all detailed data needed for analysis and drawing Conclusions. 3697 female (65.8%) and 2903 male (72.3%) had as little as one type of dyslipidemia and the total prevalence was (68.5%). In female group, 1179 cases (34.8%) and in male group, 1165 cases (42.8%) had no risk factor for dyslipidemia (Primary dyslipidemia). There were 13 patients with renal failure. 100% of them were dyslipidemic. Total cholesterol, LDL.C and triglyceride increased and HDL.C in CRF group were lower (p<0.05) than non-CRF group. Tehran eastern population suffers from a high prevalence of dyslipidemia and a large number of persons suffer from secondary dyslipidemia. Renal failure is one of the leading causes of dyslipidemia in our society.

Helicobacter pylori (HP) infection is one of the most important causes of gastrointestinal diseases such as peptic ulcer. This bacterium has recently been reported to be associated with low serum vitamin B12 level. In this study we investigated the relationship between Helicobacter pylori seropositivity and the serum B12 level in women aging 15-49 years in Khorram Abad. This cross-sectional study conducted from 2003 to 2004 on 110 healthy women aged 15-49 years. Serum samples of patients were analyzed for vitamin B12 level and anti-Helicobacter pylori antibody. Demographic data and the history of gastrointestinal diseases were recorded in a questionnaire and then were analyzed by SPSS software. There was no significant difference between mean age of HP positive and HP negative participants. 76 out of 110 (72.2%) samples were HP positive. The rate of HP seropositivity was significantly higher in patients with serum vitamin B12 level less than 12 pg/ml. who had lower and moderate vitamin B12 levels (145-180 pg/ml), that is 94% vs 64.5%, P<0.013. High HP seropositivity rate among patients with low-normal less serum vitamin B12 levels than normal indicates that there may be an association between HP infection and serum vitamin B12 levels.

Women suffer more often from depression than men. Social research suggests that high androgen levels cause aggressive behavior in men and women, and consequently cause depression. The purpose of this study was to determine serum levels of androgens, especially testosterone, in patients with depression. In this case-controlled study, we measured serum testosterone and dehydroepiandrosterone sulfate levels in 30 women with depression and 30 control subjects of the same age, weight, body mass index (BMI) and menstruation cycle. Total testosterone and free testosterone levels were significantly higher in patients with depression (202.3 ng/dl and 0.4 ng/dl respectively) than in the control group (140.3 ng/dl and 0.1 ng/dl respectively). There was no significant difference in dehydroepiandrosterone sulfate levels. This study may indicate a role of androgen, especially testosterone in the pathogenesis of depression.

Vomiting is one of the most common problems during pregnancy periods which happens in 50% of the pregnant women. Hyperemesis gravidarum is a rare status that 1 out of 500 pregnant women suffer from it. Although the reason of HG is unknown, but several studies indicate a relationship between HG and helicobacter pylori. So the aim of this study was to assess the relation between H.pylori infection and hyperemesis gravidarum and to compare it with healthy ones. In this case control study 100 pregnant women with HG and 100 pregnant controls, at the same gestational weeks, referred to the city clinics were studied. Then H.pylori serum immunoglobulin IgG concentration was determined in the case and control groups by ELIZA method and serologic tests and analyzed using SPSS software. Results showed that the prevalence of H.pylori infection was significantly higher in patients with HG (79.8%) than in controls (46.8%) with a P<0.001. There were no significant differences in maternal age, gestational age and social economic status between case and control groups. Results of this study indicate that H. pylori can play an important role for etiology of hyperemesis gravidarum.