mina yaghoobi

Spinal cord injury (SCI) is characterized by serious both motor and sensory disability of the limbs below the injured segment. It is the most traumatic disorder among central nervous system (CNS) conditions which not only leads to psychological and physical harm to patients but also results in a dramatic loss in the life quality. Many efforts have been developed to find a therapeutic approach for SCI; however, an effective treatment has not yet been found. The lack of effective treatment approach and rehabilitation of SCI underscores the need to identify novel approaches. Tissue engineering associated with stem cells has been recently introduced as an effective treatment approaches for traumatic SCI. Although, low survival rates, immune rejection, cell dedifferentiation, and tumorigenicity have been addressed for tissue engineering. Regenerative medicine is an interdisciplinary field developing and applying tissue engineering, stem cell (SC) therapy, and SC-derived extracellular vesicle therapy that aims to provide reliable and safe ways to replace injured tissues and organs. The application of mesenchymal stem cells-derived extracellular vesicles (MSC-EVs) has recently attracted attention to improve central nervous system dysfunction such as SCI, mainly by promoting neurogenesis and angiogenesis.

In this review article the latest information of SCI improvement using stem cell-derived extracellular vesicles published data in the Web of Science, Scopus, Science Direct and Pub Med databases were collected. 

The data collected show that MSC-EVs, including exosomes, alone or in combination with scaffolds can can regenerate the injured nerve in SCI.

This study summarizes the efficacy of MSC-EVs, including exosomes, alone or in combination with scaffolds in the treatment of SCI and then discusses the therapeutic outcomes observed in SCI experimental models following treatment with MSC-EVs alone or loaded on scaffolds in particular collagen-based scaffolds.

Spinal cord injury (SCI) is a severe neurological disease leading to poor quality of life.

The regenerative effect of adipose-derived mesenchymal stem cells (AD-MSCs) encapsulated into fibrin, and collagen hydrogel scaffolds on a rat model of SCI was investigated using clinical and histopathological examinations.

A total of 18 adult male Wistar rats (250 - 300 g) were prepared and randomly divided into three equal groups, each with six rats, including the control or SCI group (SCI contusion model without treatment), SCI contusion model treated with AD-MSCs encapsulated in fibrin hydrogel, and SCI contusion model treated with AD-MSCs encapsulated in collagen hydrogel groups. Clinically, functional recovery or hindlimb locomotor activity was assessed using Basso, Beattie, and Bresnahan's (BBB) scoring system four weeks post-treatment. The rats were sacrificed at week four post-treatment, and their spinal cords were examined histopathologically.

Faster functional recovery indicated with hindlimb locomotor activity was seen in both treatment groups compared to the control group. Severe polio and leuko-myelomalacia associated with disruption of spinal cord structure were identified in the control group. Mild polio and leuko-myelomalacia associated with mild to moderate disruption of spinal cord structure were seen in the collagen hydrogel + AD-MSCs and fibrin hydrogel + AD-MSCs groups.

AD-MSCs encapsulated into fibrin and collagen hydrogels, as two of the most promising ECM-based or natural scaffolds have the potential to be developed in neural tissue engineering (NTE), such as for the treatment of SCI.

Maslow’s human motivation theory has been considered as one of the most influential theories of psychology since its emergence. In this theory، basic human needs are ranked in a pyramid. Based on this hierarchy، basic needs، such as physiological needs، safety needs، etc.، should be met first. In this hierarchy، the need for self-actualization and transcendence are placed at the highest level. Thus، an inevitable order and hierarchy of needs govern the fulfillment of the needs. Using a qualitative comparative approach and content analysis method، this study tries to critically review Maslow’s hierarchy of needs theory from the point of view of Islam and The Holy Quran. The results of the study show that in order to achieve self-actualization and transcendence defined by The Quran، it is not necessary to fulfill all the prior needs. Even in some cases، it is necessary for humans to disregard some or all their prior needs. Some examples of contradiction mentioned in The Quran include fasting، avoiding hypocrisy، martyrdom، and divine trials.

Administrative corruption, in all its different forms and with all its harmful consequence, is considered both a moral and a legal problem from the perspective of Islam. This phenomenon originates from personal, economic, cultural, political and judicial factors. Hence, the religion’s strategies to prevent and combat the problem include informal and internal strategies like Taqwa (God-fearing), patience, faith in the Hereafter, social responsibility, etc, as well as official strategies such as political, economic, cultural and judicial ones. This research, with a review of the verses of the holy Quran and the Hadiths (sayings) of the Infallible (AS), explains and clarifies the factors that lead to corruption and ways to combat them. According to the results of this study, Islam has a multifaceted view of the issue of uprooting the causes and origins of administrative corruption and recommends decisive action against such corruption when it happens.