رژیم غذایی پرچرب

The purpose of this research is to determine the effect of 6 weeks of aerobic training and cinnamon supplementation on the expression of the resistin gene in the slow twitch muscle tissue of male Wistar rats fed with a high-fat diet. The statistical sample of the research consists of 50 two-month-old male Wistar rats, which were randomly divided into five groups, and each group consisted of ten rats. The mice had daily access to 20 grams of pellets and 10-12 ml of water per 100 grams of body weight. The groups receiving high-fat food used high-fat food emulsion daily of 1.5 mg per kilogram of body weight. The aerobic exercise group participated in the aerobic exercise program on the electronic treadmill five days a week for six weeks. The cinnamon extract group received 200 mg per kilogram of body weight for 6 weeks. To analyze the data, dependent t-tests, one-way analysis of variance and, Tukey's follow-up were used. The results showed that the effects of a high-fat diet, combination of high-fat diet and aerobic exercise, the combination of high-fat diet and cinnamon, and a combination of high-fat diet, aerobic exercise and cinnamon on resistin gene variables in slow-twitch muscle tissue are significant (p ≥ 0.05). As a result, considering the optimal and favorable effects of taking cinnamon extract along with performing aerobic exercise on body weight and resistance gene expression and adjusting the adverse effects of consuming a high-fat diet, it is recommended to use cinnamon extract along with performing aerobic exercise.

Adiponectin is a peptide hormone that is secreted from adipose tissue in humans and is effective on fat and glucose metabolism. Interleukin-6 also has the main role in various types of host defense mechanisms, including immune reactions and acute phase reactions. Therefore, the aim of the present study was to compare the short-term effects of aerobic exercise and high-fat diet and curcumin extract on the expression of adiponectin and interleukin genes in six muscle tissues of male Wistar rats. For this purpose, 50 two-month-old male rats were prepared and divided into five control groups, high-fat diet, curcumin and high-fat diet, exercise and high-fat diet, curcumin + exercise + high-fat diet. Data analysis was compared using one-way analysis of variance. The mean of intra-group differences was also compared using the one-way statistical test. The results showed that the average expression of the adiponectin gene of the subjects showed a significant difference among the 5 groups. The results of Bonferroni's post hoc test also showed a significant difference between the control group and other groups. Also, the expression of interleukin 6 gene increased in two groups - high-fat diet and high-fat + curcumin diet group compared to the control group. But in two groups of high-fat diet + exercise and high-fat diet + exercise + curcumin group, there was a significant decrease.

Obesity has become a global problem today. Obesity can be caused by sedentary lifestyle and a high-cholesterol diet. This condition increases oxidative stress and decreases the activity of oxidative enzymes, resulting in many complications, including cardiovascular disorders. Aerobic exercise and avoidance of high-fat diets are used as a non-pharmacological intervention to increase antioxidant capacity; however, the exact mechanisms of this on the cardiovascular system have not yet been fully identified. The aim of this study was to evaluate the effect of 12 weeks of aerobic exercise on cardiac antioxidant enzymes in mice fed high cholesterol diet. Thirty-two laboratory Wistar rats (191.2 ± 19 g), age 6-8 weeks were randomly assigned to four groups after the hypercholesterolemia induction of half of the rats (adding 1% cholesterol to the food of the rats and sampling the tails of the rats). These four groups comprised of the aerobic exercise-normal nutrition group (n=8), hypercholesterolemic group (n=8), aerobic exercise- hypercholesterolemic group (n=8) and normal nutrition group (n=8). Each endurance exercise training session was held five days a week for 12 weeks. Twenty-four hours after the last training session, the rats were killed and the cardiomyocytes were removed. Moreover, the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) enzymes was evaluated by specific kits. The results showed that increasing blood cholesterol had a statistically significant effect on reducing SOD, CAT, and GPX in heart tissue (p=0.001). Furthermore, it was found that aerobic exercise significantly increases the activity of antioxidant enzymes in cardiomyocytes (p=0.001). The highest decrease in the level of antioxidant enzymes was related to the hypercholesterolemic group and the highest increase was related to the aerobic exercise-normal nutrition group. Cholesterol-rich diets reduce the activity of antioxidants in the heart. Although aerobic exercise increases the heart’s antioxidant activity, it seems that avoiding a high-cholesterol diet can play a more effective role.