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Obesity has become a global problem today. Obesity can be caused by sedentary lifestyle and a high-cholesterol diet. This condition increases oxidative stress and decreases the activity of oxidative enzymes, resulting in many complications, including cardiovascular disorders. Aerobic exercise and avoidance of high-fat diets are used as a non-pharmacological intervention to increase antioxidant capacity; however, the exact mechanisms of this on the cardiovascular system have not yet been fully identified. The aim of this study was to evaluate the effect of 12 weeks of aerobic exercise on cardiac antioxidant enzymes in mice fed high cholesterol diet. Thirty-two laboratory Wistar rats (191.2 ± 19 g), age 6-8 weeks were randomly assigned to four groups after the hypercholesterolemia induction of half of the rats (adding 1% cholesterol to the food of the rats and sampling the tails of the rats). These four groups comprised of the aerobic exercise-normal nutrition group (n=8), hypercholesterolemic group (n=8), aerobic exercise- hypercholesterolemic group (n=8) and normal nutrition group (n=8). Each endurance exercise training session was held five days a week for 12 weeks. Twenty-four hours after the last training session, the rats were killed and the cardiomyocytes were removed. Moreover, the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) enzymes was evaluated by specific kits. The results showed that increasing blood cholesterol had a statistically significant effect on reducing SOD, CAT, and GPX in heart tissue (p=0.001). Furthermore, it was found that aerobic exercise significantly increases the activity of antioxidant enzymes in cardiomyocytes (p=0.001). The highest decrease in the level of antioxidant enzymes was related to the hypercholesterolemic group and the highest increase was related to the aerobic exercise-normal nutrition group. Cholesterol-rich diets reduce the activity of antioxidants in the heart. Although aerobic exercise increases the heart’s antioxidant activity, it seems that avoiding a high-cholesterol diet can play a more effective role.

The present study was conducted to investigate the effect of aerobic training with resveratrol supplementation on regulatory and executive factors of cardiomyocytes apoptosis in streptococci diabetic male rats

In an experimental study, 50 male rats were randomly divided into 5 groups of 10 healthy controls, diabetics, resveratrol supplements, aerobic training and complementary resveratrol + aerobic training. Diabetes was induced by single injection of streptozotocin, ml / kg. The program of exercise, exercise and supplementation groups began for 8 weeks and 5 days a week on the training of Treadmill. All animals were completely and similarly treated, followed by 14-12hours of fasting and 48 hours after the last training session, anesthetized and sacrificed. After cardiac output and homogenization, the concentration (GPX, SOD, and MDA) was measured as ELISA. 

After induction of diabetes, the concentration of GPX and SOD in the cardiac system was significantly lower than healthy controls, while MDA concentration increased significantly in these conditions. However, exercise interaction and resveratrol had a significant effect on the concentration of cardiac SOD, while the interaction of these two effects there was no concentration of MDA and GPX in the heart.

Aerobic exercise and resveratrol have a beneficial effect on cardiac apoptosis in inducing diabetes, but their interaction is not significant in the process of cardiac apoptosis. Of course aerobic exercise and resveratrol can be used as complementary medicine for protecting myocardial cells against the invasive induced apoptosis induced by diabetes.

Selenium (Se) is a beneficial element for plant but at high concentrations, it is toxic and causes in plant growth retardation. There is limited information about the effects of Se on salinity-induced damages on wheat. Therefore this study was carried out to investigate interaction of salinity and Se on root and shoot dry matter yield, activity of GPX, and concentrations and uptake of selected micronutrients in roots and shoots of wheat. Two wheat cultivars (Triticum aestium cvs. Kavir and Back Cross-Rushan) differing in micronutrient efficiency were treated with four levels of Se (0, 20, 40 and 150 µM) and two salinity levels (0 and 100 mM NaCl). The effect of application of different Se concentrations on the shoot dry matter yield of wheat varied upon crop cultivar and salinity level. Application of Se at 20 µM concentration resulted in increase of shoot dry matter weight of ‘Back Cross-Rushan’ under salinity conditions. Selenium at 40 µM level increased shoot dry matter yield of Kavir cultivar at non-saline conditions. The effect of Se on activity of GPX was dependent on the wheat cultivar and Se level. In general, activity of GPX in roots of both wheat cultivars exposed to salinity stress was increased by application of 20 and 40 µM Se. Also, at saline conditions, application of 20 µM Se increased activity of GPX in shoots of both wheat cultivars. According to the results obtained from the present study, Se nutrition had positive effects on dry matter yield of wheat especially in salinity condition, but this effect depended on crop cultivar and applied Se concentration.