جستجوی مقالات مرتبط با کلیدواژه « quinazolinone » در نشریات گروه « شیمی »

In medical chemistry, aminoqunoline-7-hydroxylic acid is considered as a very useful and attractive nucleus supporting compound. Since then, it has become a central moiety in a variety of bioactive compounds. We synthesised new antioxidants from 6-aminoqunoline-7-hydroxylic acids and determined their antioxidant activity. In cellular and intracellular physiological responses, the peptides are usually considered as the main regulators and widely expected to be used in disease treatment. Due to their therapeutic significance, the two vital molecules, aminoqunolines and peptide derivatives have been combined together into a single molecule by changing the various amino acids synthesized by different chemical reactions. Analysis and valdation of such compunds by Fourier transform infrared (FTIR), 13C and (1H) nuclear magnetic resonance (NMR) spectra was done. The specific optical rotation (SOR) has also been determined. The evaluation of in vitro antioxidant activities of such multifunctional compounds was carried out using the DPPH and Nitric oxide free radical scavenging methods. Activity was noted for derivatives from 6-aminoqunoline-7-hydroxylic acid, while other members showed a higher antioxidant activities than the ascorbic acid. All the five compounds synthesized were studied for their potent antioxdinat activity. A2 and A3 showed highest DPPH scavenging activity at 4 µM. Activity was increased for A3 upto 63.3% and 66.8% on increasing the alkyl chains and polar side chains respctively. A1 was found to exhibit high nitric oxide scavenging activity with 31.2% of activity. This study confirmed the synthesis of new compounds through infrared and NMR spectra. Moreover, they are highly effective in scavenging free radicals.

Novel substituted quinazolinone derivatives based on 8-hydroxyquinoline were synthesized and identified by hydrogen-1 nuclear magnetic resonance, carbon-13 nuclear magnetic resonance, and elemental analysis. The corrosion inhibition of these compounds in 1 M HCl Solution for mild steel was evaluated using potentiodynamic polarization measurements, electrochemical impedance spectroscopy, weight loss measurements. It is showed that these compounds are good inhibitors for mild steel corrosion in 1.0 M HCl solution which act as mixed type inhibitors. So, the inhibition efficiency was increased with inhibitor concentration in the order of QZn>QZ which depended on their molecular structures. Maximum values of inhibition efficiency 96% and 79% were obtained at low concentration (10-3 M) for QZn and QZ respectively. It is found also that the inhibition efficiency of these compounds slight decrease with temperature. In addition, the thermodynamic adsorption parameters at different concentrations were investigated and discussed. The both inhibitors as good acid corrosion inhibitors and were found to obey Langmuir adsorption isotherm. Additionally, the corrosion properties were also investigated by UV-visible spectrophotometry to obtain information on bonding mechanism between the metallic surface and the inhibitor. Scanning Electron Microscopy (SEM) was performed and discussed for surface study of uninhibited and inhibited mild steel samples.

Quinazolinones were synthesized through the one-pot three-component reaction of aromatic aldehydes, isatoic anhydride, and urea under solvent-free conditions using sulfonic acid functionalized mesoporous silica (SBA-Pr-SO3H). The propargyl ether containing 2,3-dihydroquinazolin-4(1H)-ones were reacted with sodium azide in the presence of CuI to gain the new triazole-quinazolinone products.

Utilization of benzoxazinone for synthesis quinazolinone derivatives with 3-heterocycle side chain. treatment of benzoxazinon 1 with cyano acetohydrazide or thionocarbohydrazide gave the quinazolinone derivatives 2 or 12. quinazolinone 2 has been utilized as synthon for new  pyridinone, oxazet, thiazole, thiazolidinone and quinazolinone derivatives. Thiosemicarbazide and thiosemicarbazone derivatives are synthesized from quinazolinone 12 by different route. The structures of the new compounds were established on the basis of IR, 1HNMR, mass spectral data, and elemental analysis.