آمیلوئید

Lemon balm (Melissa officinalis) is one of the most important medicinal plants and belongs to the mint family, which is known as a medicine that increases memory. The purpose of this study was to investigate the effective compounds, anti-microbial effects and inhibitory effects of hydroalcoholic extract of lemon balm for the production of amyloid nanofibers as an effective agent in Alzheimer's disease.

The effective compounds of lemo balm plant were investigated by gas chromatography-mass spectrometry. Antimicrobial effects on two bacteria Escherichia coli and Staphylococcus aureus were investigated by well method and the values ​​of minimum inhibitory concentration and minimum bactericidal concentration were determined. The inhibitory effects of lemon balm extract on the fibrillation of bovine serum albumin were investigated by Concord absorbance method.

The presence of the active substance pyrrolidinone was confirmed with a probability of 90%. The diameter of the halo of non-growth of hydroalcoholic lemon balm extract for Staphylococcus aureus and Escherichia coli was 20 and 17 mm, respectively, and the MIC and MBC values ​​were 0.137, 0.068, 0.068, and 0.068 g/ml, respectively. Liter was obtained. The maximum inhibition of amyloid nanofibers was observed at a concentration of 4 mg/ml of lemon balm extract.

lemon balm extract with proper antimicrobial effects and lower side effects and cost than other synthetic drugs can have a good effect against infectious agents. By inhibiting the production of amyloid nanofibers, lemon balm extract can be useful for reducing the complications of Alzheimer's disease.