آدیپوژنز

Understanding adipogenesis, the process of adipocyte development, may provide new insights to treat type II diabetes and related metabolic diseases. The present study investigates the effect of eight weeks of moderate-intensity continuous training and L-carnitine supplementation on Wnt10b protein expression related to visceral adipose tissue adipogenesis in streptozotocin (STZ)-induced diabetes in larg rats.

In an experimental clinical-intervention study, 50 large laboratory mice were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplemental diabetic with exercise (D + LC + T). The training program consisted of three times a week for 30 minutes on a treadmill at a speed of 15 meters per minute. Five days a week, 30 mg/kg of L-carnitine was given through drinking water. Expression of Wnt10b protein at visceral fat was measured by western blot method. Data analysis was performed with one-way analysis of variance and Tukey's post hoc tests at a significant level (P< 0.05).

The results showed that the expression of Wnt10b protein, the Lipolysis inhibitory protein, in both (D+LC+T) groups and (D+T) decreased significantly (P< 0.001).

According to the results, it seems that MICT exercise with L-carnitine supplement and alone is more effective in decreasing the expression of protein associated with adipogenesis in visceral fat. However, a clear statement requires further research in this area.

Adipogenesis is a dynamic process that leads to the phenotype of mature fat cells and plays a significant role in obesity and diabetes. The present study investigates the effect of Eight –Weeks of High-Intensity Interval Training (HIIT) and L -carnitine Consumption on the expression of BMP7 protein in visceral adipose tissue in diabetic rats.

In an experimental clinical-intervention study, 50  male Wistar rats were divided into 5 equal groups of control (C), diabetic (D), supplemental diabetic (D + LC), diabetic with exercise (D + T), supplement and exercise (D + LC + T). The training program consisted of eight weeks, 5 sessions per week (6 to 12 2-minute sessions with an intensity of 85-90% of the maximum speed). The subjects received 30 mg/kg body weight L-carnitine through drinking water. Visceral fat was extracted and the expression level of BMP7 protein was assessed using Western Blotting. Data analysis was performed by one-way ANOVA and Tukey post hoc test at a significant level of (P< 0.05).

The results showed that the expression of BMP7, the adipogenesis stimulating protein, in (D + T) and (D + LC + T) groups increased significantly (P< 0.001).

According to the results, it seems that HIIT exercise alone and with L-carnitine Consumption is more effective in the expression of protein associated with adipogenesis expression in visceral fat. However, a clear statement requires further research in this area.

Nowadays, high prevalence of obesity and its consequences is considered as a major health complication worldwide. Overweight increases risk of diseases such as hypertension, cardiovascular diseases, type 2 diabetes, certain types of cancer, gallstone, and osteoarthritis. Obesity is defined as growth of visceral white adipose tissue. On the other hand, in order to supply for metabolic needs of adipose tissue, depends on appropriate growth of blood vessels, either in number and/or in size (angiogenesis/arteriogenesis). Moreover, the very close interconnection between adipogenesis and angiogenesis has been considered in recent years. Therapeutic interventions for treating obesity by targeting vessels of adipose tissue illustrate a promising future. In this review, we discussed adipose tissue, important roles and functions of vessels in adipose tissue, obesity, and angiogenesis. We finally presented suggestions on how to use anti-angiogenesis agents for treatment of obesity as a novel approach.