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Diabetes is one of the most common chronic diseases which also affects individuals' mental and psychological characteristics. The purpose of this study was to investigate the effectiveness of positive-psychology training on psychological well-being and its dimensions on patients with type II diabetes. This quasi-experimental study was conducted based on a pretest-posttest design with a control group and follow-ups. The participants were selected through convenient sampling from patients with type II diabetes who referred to Hazrat-e-Ali Health center in Isfahan during 2017. Subsequently, the participants were randomly divided into two groups of 15 people. The experimental group received positive psychology training, whereas the control group did not receive any treatment. Both groups were evaluated before and after the intervention and in the follow-up stage through Reef's Psychological Well-Being Questionnaire (1980). The data were analyzed using repeated measure ANOVA. The results showed that positive psychology training correlated significantly with psychological well-being, self-acceptance, positive relationships with others, having a purpose in life, and environmental domination in patients with type II diabetes. In addition, there was a significant difference between the experimental and control groups regarding the abovementioned variables. However, no significant difference was observed between the intervention and control groups regarding self-autonomy and personal growth (P<0.001).). Positive psychology training effectively improves the psychological well-being of patients with type II diabetes. Therefore, it is recommended that this treatment approach be used to help improve the psychological well-being of these patients.