مشهد

The purpose of this study was to investigate the effectiveness of Islamic spiritual dignity therapy on depression and death anxiety of dialysis patients.

This semi-experimental study used a pre-test and post-test design with a control group. The statistical population included all dialysis women in Mashhad city, and 12 subjects (6 in the control group and 6 in the experimental group) were selected as a sample from the Mohaban Dialysis Center in Mashhad by the researcher's call in 2021. In this study, people were replaced by a non-probability (voluntary) sampling method and randomly in two experimental and control groups. During the sessions, one of the people in the experimental group had a stroke and died, and our sample fell. In the pre-test stage, the subjects of both groups responded to Beck's depression questionnaire (1996) and Templer's death anxiety questionnaire (1970). The subjects of the experimental group were subjected to dignity group therapy during six sessions each session for two hours, while the control group did not receive any treatment. At the end of the plan's implementation, both groups answered the mentioned questionnaires again. Finally, the data collected were analyzed by covariance analysis.

Dignity therapy has a positive effect on dialysis patients in reducing the two components of depression and death anxiety (P<0.01). Dignity therapy has established a significant difference between the control and experimental groups.

The results showed that dignity therapy is effective in reducing depression and death anxiety in dialysis patients. Islamic spiritual dignity improves depression and death anxiety of individuals, and this group therapy can be used to promote the reduction of depression and death anxiety.

Pseudomonas aeruginosa is an opportunistic pathogen that causes widespread infections in hospitals. Pseudomonas aeruginosa has become resistant to a variety of antibiotics due to the overuse of antibiotics. One type of resistance acquired by this bacterium is resistance to aminoglycoside drugs. The most important mechanism of this resistance is the enzymatic inactivation of aminoglycosides by their modifying enzymes. The rmtB gene is involved in this resistance and because silver nanoparticles have antibacterial properties, the present study was conducted to evaluate the expression level of rmtB gene in Pseudomonas aeruginosa specimens treated with silver nanoparticles.

In the current study experimental, 53 samples were collected from 11 laboratories in Mashhad during 1398-1399. Samples were identified using standard laboratory methods and specific culture. PCR method was used to evaluate the frequency of rmtB gene. In order to evaluate the antibiotic susceptibility pattern of the strains, the disk diffusion method based on the CLSI protocol (2018) was used. Silver nanoparticles were made from ginger extract and Real time PCR was used to investigate the effect of silver nanoparticles on rmtB gene expression.

Out of 53 samples of Pseudomonas aeruginosa, 51 samples were resistant to more than two aminoglucosides. Phenotypic evaluation of the antibiotic resistance pattern of aminoglucoside-resistant Pseudomonas aeruginosa strains showed that 61% were resistant to amikacin, 84% to gentamicin and 23% to tobramycin. Also, out of 53 samples, 76% were resistant to all three aminoglycosides. The minimum inhibitory concentration in the agar dilution method for silver nanoparticles was up to 500 μg/ml. Molecular analysis showed the presence of rmtB gene in all samples and the result of real time PCR analysis showed that the effect of silver nanoparticles on rmtB gene expression was significant (P <0.01).

There was high resistance to aminoglycoside in samples collected from Mashhad. Silver nanoparticles had a significant effect on reducing the expression of rmtB gene (P <0.01).

Purpose of this study was to investigate of prevalence, phylogenetic groups and antibiotic resistance pattern EAEC isolated from diarrheic children in Mashhad city.

This cross-sectional study conducted for one year. In total, 450 diarrhea samples of children under 10 years of age were collected from children's specialized hospital in Mashhad. After isolation of Escherichia coli, EAEC isolates were identified by PCR molcular method. Phylogenetic groups of EAEC isolates were determined using the original and updated 2019 method. Antimicrobial susceptibility test was performed using disc diffusion methods(Kirby-Bauer method) against 12 antibiotics.

44(9.8%) EAEC isolates were identified from 422(93.8%) Escherichia coli isolates by PCR. Seven phylogroups including D(40.9%), unknown(27.3%), G(11.4%), B1(9.1%), F(4.5%), B2(4.5%) and A(2.3%) were detected among EAEC isolates.The highest diversity of antibiotic resistance patterns was related to Phylogroup D. EAEC isolates showed the highest resistance to amoxicillin and erythromycin 100%. Overall, 97.7% of EAEC isolates were with multiple drug resistance(MDR).

The present study showed a significant presence of EAEC strains. Considering the role of EAEC in chronic diarrhea and growth retardation syndrome in children, it is suggested that the identification of EAEC strains to be considered in diagnostic laboratories in cases of children’s diarrhea. on the other hand, due to the high prevalence of multiple resistances, antibiogram test is required to treat diarrhea in children.

Access to quality information is essential for greater patient participation in treatment. This study aims to investigate the information sources of organ transplant recipients in Mashhad, Iran.

This analytical cross-sectional study was carried out from December 2017 to May 2018. Participants were 115 patients who received liver and kidney transplantation in Montaseriyeh Hospital in Mashhad. The research instrument was a researcher-made questionnaire with acceptable validity and test re-test reliability. Data analysis was performed in SPSS software, version 16.

The Mean age of the participants was 35.7±11 years. Most of them had the desire to receive more information about their disease (93%). The attending physician (Mean=8.91), Nurses (Mean=7.38), and other organ transplant patients (Mean=6.80) were the most popular sources of information for patients. The main reasons for using information sources were “having better understanding of the disease” (Mean=8.32), and “curiosity to learn more about the disease” (Mean=7.73). The most important problems in obtaining information were the lack of familiarity with medical terms (Mean=7.32) and information sources (Mean=7.16), and lack of access to information in Persian (Mean=7.14). Regarding the best type of educational method for information acquisition, verbal/face-to-face method got the highest score (Mean=9.05).

An appropriate and organized program should be developed for organ transplant patients to increase their health literacy as one of their undeniable rights.

Evidence shows that most diseases, including heart disease, cancer, pneumonia, and health inequalities, are all strongly influenced by social characteristics. Therefore, this study was conducted to determine the relationship between social participation and general health of the elderly in Mashhad

The present study was a cross-sectional descriptive analysis for which 350 elderly retirees (employees) and retirees of the Social Security Organization (workers), based on a multi-stage method ((class, systematic random access and available) based The proportions were proportionally selected.The data were collected using the elderly demographic information questionnaire, GHQ general health questionnaire and social participation questionnaire.The data obtained using SPSS-v24 software and using correlation tests, independent t-test, one-way analysis of variance And multiple linear regression was analyzed.

The mean and standard deviation of age of the research units was 68.91 7 7.62 years. The mean scores of general health and social participation were 15.19 and 31.71, respectively. The variables of social participation along with age, marriage, gender, employment, source of income, income satisfaction, illness and life companions as independent variables predicted 15% of general health (P <0.05).

In this study, no significant results were observed between the relationship between social participation and public health in retired elderly. Further research focusing on more individual factors such as age, marital status, gender, employment, source of income, income satisfaction, illness, and life companions can be useful for planning and implementing comprehensive and effective strategies.

Invasive fungal infections due to Aspergillus and Candida often occur in leukemia and transplantation patients because of a severe compromised in their immune systems. Rapid identification and initiation of treatment in the early stages of the disease can reduce mortality from fungal infection. The aim of this study was the identification of invasive fungal infections by Real-time PCR in patients with hematologic disorders and bone marrow transplantation.

patients with immunodeficiency hospitalized in Mashhad hospitals between March to November 2018 were evaluated for invasive fungal infections using TaqMan Real-time PCR with fluorescence probes and specific primers to identify fungal DNA in peripheral blood samples.

Seventy-five patients participated in this study. The female/ male ratio was 34 (45.3%)/ 41 (54.7%). The most common underlying disease was acute lymphoblastic leukemia (45.3%) and acute myeloid leukemia (32%) and the lowest was related to haemophagocytic patients with lymphohistiocytosis (1.3%). Blood culture results showed isolation of non-albicans Candida (13.3%) and Candida albicans (1.3%). Aspergillus species was not isolated from the blood culture. Real-time PCR were positive for Candida albicans and Aspergillus species in 5 (6.7%) and 9 patients (12%), respectively and 61 patients (81.3%) had negative results for invasive fungal infections.

Fungi are one of the major cause of infections in the patients with hematologic disorders. Real-time PCR techniques can be a reliable and fast way to diagnose these infections and manage the disease in high-risk individuals.

Heavy metals contamination of soils is one of the main environmental problems. Heavy metals are considered as one most dangerous groups of pollutants because of their toxicity and stability. The biological and ecological importance of heavy metals is due to their characteristics of polluting, their toxicity, persistence and bioaccumulation. The aim of this study was to investigate the spatial distribution of heavy metals in region Dehnow Shandiz (North West of mashhad).

In the present study, 20 soil samples (10-30 cm depth) collected and total concentration of As, Cd, Co, Cr and Ni were measured using Atomic absorption spectrophotometer device. Also, some other soil properties including PH, Organic carbon, CEC and soil texture proportions were measured.

The results showed that the average concentrations of As, Cd, Co, Cr and Ni in the study area were 10.87, 0.26, 14.8, 56.6 and 68.2 mg/kg respectively. Also the results of statistical analysis showed that the standard deviations of As, Cd, Co, Cr and Ni in the study area were 1.97, 0.16, 1.32, 19.47 and 17.39 respectively.

The results indicate that the average concentration of Ni in the soil of study area were higher than the standard of the Environmental Protection Organization of Iran and As, Cd, Co and Cr were lower than the standard. The presence of serpentinite soils has increased the concentration of nickel in the region.

The aim of this study was to investigate dust origin particulate (PM2.5) in Mashhad city in a long period of time (2014-2019) based on unhealthy days. Furthermore, changes in meteorological parameters and their relationship with dust storms have also been investigated.

In order to locate dust pollution hotspots in mashhad air, first, information about unhealthy days of Mashhad city in a 5-year period was obtained from the site of Mashhad Pollutants Monitoring Center and then HYSPLIT model was used to locate air pollution hotspots caused by particulate matter. To verify the results, the outputs obtained from this model were also compared with the DREAM8b model.

By examining the meteorological parameters and its relationship with the outputs obtained from THEHYSPLIT and DREAM8b models, the maximum wind speed and relative humidity were obtained in autumn. There was no rainfall in the studied days (19 days) and the highest temperature was related to summer, indicating the relationship between the occurrences of polluted days due to particulate matter less than μ 2.5, wind speed and relative humidity in autumn. The results of the two models showed that the southern and northeastern regions of Mashhad city had the highest source of dust particles during the studied days.

 Although in previous articles, the origin of dust in Mashhad city was announced outside the geographical boundaries of the province, long-term investigation at low altitude (below 10m) showed that local origin of dust have an essential role in air pollution in Mashhad city under unstable atmospheric conditions. Inappropriate use of agricultural lands and severe changes in land use often in the northern region and implementation of construction projects such as the southern belt of Mashhad city play essential roles in increasing PM2.5 particles in the air of Mashhad. This finding shows the importance of decision making for the implementation of soil stabilization projects etc... at the local level.

Nosocomial infections have always been one of the major health problems, and it is becoming increasingly important and a challenge for the health system of different countries. In this study, the contamination in the environment and equipment of two hospitals of Mashhad were studied.

This cross-sectional study was performed in two academic hospitals. The sampling method was convenient based on policy of infection control committee of each hospital. Environmental samples were collected from water, sink, patient bed and incubators. Samples were cultured in bacterial culture media and phenotypically identified. .

Out of 323 samples, 272 (84.2%) were from Qaem Hospital and 51 (15.8%) from Imam Reza Hospital. Overall, 47.1% of samples of Imam Ghaem hospital (128 samples) and 33.3% of samples of Imam Reza hospital (17 samples) were positive (p = 0.071). Overall, the most prevalent organisms were Bacillus (54 samples, 16.7%) followed by Staphylococcus epidermidis (22 samples, 6.8%) and Staphylococcus saprophyticus (16 samples, 0.5%). Others were consisted of Acinetobacter, Enterobacter and pseudomonas spp.

Bacillus species have a high persistence in the environment due to Sporulation and their removal will be an indicator of proper environmental health. The presence of potentially pathogenic bacteria in the hospital environment reveals the importance of environmental health control and monitoring programs.

Reproductive health is not merely limited to family planning programs, rather it involves devoting broader attention to social conditions that affect a woman's overall health and role in fertility and sexuality. Regarding this, safe motherhood refers to a set of actions and activities that aims to reach a desired level of health for the mother and neonate. Therefore, this study was performed to determine safe motherhood indicators among women of reproductive age.

This descriptive cross-sectional study was conducted to investigate the safe motherhood indicators of 1,019 pregnant women referring to teaching hospitals in Mashhad, Iran, in 2020. The samples was chosen with convenient Sampling method. The necessary data were collected using a researcher-made questionnaire containing demographic and fertility characteristics. The gathered data were analyzed in SPSS software (version 16) using descriptive statistics.

Based on the results, 96% and 33.5% of the subjects referred for prenatal care and preconception care, respectively. It was revealed that 67.8% of the cases used family planning services. The first prenatal visit of 87.7% of women was in the first trimester of pregnancy. It was also found that 58.5% and 33.1% of the subjects underwent natural childbirth and cesarean section, respectively, and 6.1% of pregnancies resulted in abortion.

The results showed that most women did not refer to receive preconception care to be prepared for this period; rather, they refer for prenatal care as soon as the pregnancy occurs. About a third of women do not have a fertility plan; therefore, there is still a gap in the field of healthy reproduction program and preconception care until reaching the desired level. In this respect, it is required to adopt a suitable strategy in this field.

Road Traffic Accidents around the world cause about 1.2 million deaths each year. Also, injuries and disabilities of 20 to 50 million people are estimated annually. According to UNICEF reports Road Traffic accidents are the second leading cause of death for people between the ages of 5 and 25. Therefore, this study was conducted to determine the epidemiological indicators of mortality and road traffic injuries in children and adolescents under the age of 15 years old in Mashhad.

This is a Cross-sectional-analytical study and was done cross-sectionally. In this study, all traumatic injuries victims of Mashhad city in 2016, who referred to City Hospitals were investigated and was used by Ferdows Organization of Mashhad to collect death data. This study was a survey-based study and lacked sampling.

The findings of this study showed that the total number of children died in Road traffic accidents in 2016 was 72, of which 45 (62.5%) were male and 27 (37.5%) were female. The total number of injured children was 4298, of which 2814 (65%) were male and 1484 (35%) were female. The incidence of lesions in males and females and in both genders was 740.5, 412, and 581 per 100,000, respectively.

Our study shows that most of the deaths were due to car occupants, and this shows the importance of using seat belts and child seats. In the case of pedestrian deaths, there also seems to be an urgent need for Culture building for drivers and educate children in this area.

Spanish flu was one of the harshest historical pandemics in the northeastern Iran, which killed many local people. Its first outbreak in Mashhad dates back to August 3 and 4, 1918. This disease continued until 1920 in successive waves. The death toll of this disease in Mashhad (with a population of 100,000 people at the time) was possibly as high as 3,500. Moreover, this disease caused outbreak of other diseases. In fact, it killed five percent of this city’s population and resulted in huge deaths in this city. This paper takes the importance of Mashhad’s medical history into consideration and at the same time investigates the outstanding role of Spanish influenza, World War I, and the presence of Russians who were the main cause of this outbreak in Mashhad, and the reaction of Iranian and foreign physicians to this disease and the medicine they prescribed, as well as the significant role of British in fake Persian Famine, opium addiction, and food poverty.

kidney cancer has a frequency of 3% in all cancers and this frequence has increased recently. We tried to investigate the prevalence, stage and type of renal tumors within 15 years in Mashhad.  

Methods & Materials: 

In this cross-sectional study, the pathologie of patients undergone nephrectomy due to tumor in previous (2001-2002) and recent(2016-2017)years in Imam Reza Hospital in Mashhad, were examined. All records of both groups were reviewed including demographic information and  mass informations such as number, size and type of pathology.  

Among 145 patients, 45 (31%) were prevoiusly registered in 2001-2002 and 100 (69%) were recently registered in 2016-2017. 71% of new cases and 55.56% of prevoius cases were male and both groups were in second group. There was no significant differences in the frequency distribution of gender (P = 0.07), disease grade (P = 0.75), mass location (P = 0.24), resection type (P = 0.89), lymphovascular invasion (P = 0.74) and extracapsular (P = 0.84) between old and new cases. The final diagnosis in 95% of new cases and 84.4% of old cases was renal cell carcinoma (RCC) and there was a significant difference in the frequency distribution of the final diagnosis between old and new cases (P = 0.02).  

This study shows the general pattern and increasing incidence of RCC in Mashhad, which requires further studies to investigate the etiology and risk factors and even eliminate them if possible.

Head lice as external parasite contamination is one of the health-threatening issues that despite the upgrading of health, is still a health problem.

This clinical trial study was carried out on 3062 elementary school female students examined for head lice infection in Mashhad, Iran, using cluster-randomized sampling method. The infected individuals were divided into six treatment groups. Three types of drugs, including lindane 1%, permethrin 1%, and dimethicone 4%, along with vinegar were used in this study. The results of the treatment were recorded after 7, 14, and 21 days during the reanalysis of the students. The results were analyzed by the Chi-square test and logistic regression.

The results showed that 417 (13.6%) students were infected with head lice. The levels of efficacy in the treatment groups of permethrin 1%, lindane 1%, and dimethicone 4% were 27.2%, 31%, and 30.4% after 1 week of treatment, 83.2%, 69.8%, and 69.6% after 2 weeks, and 96%, 91.5%, and 91.4% after 3 weeks, respectively. The levels of the effectiveness of the shampoos with vinegar were 64.2%, 96.1%, and 67.6% after 1 week, 90.6%, 100%, and 100% after 2 weeks, and 100%, 100%, and 100 % after 3 weeks, respectively.

According to the obtained results of this study, permethrin 1% and dimethicone lotion are recommended for the elimination of head lice contamination in children. Moreover, the efficacy of permethrin 1%, lindane 1%, and dimethicone 4% after 3 week, compared to their use, along with vinegar was shown to be 100%.

Gynecologic cancers are the important cause of women's mortality in the world. Considering the importance of epidemiological recognition of gynecologic cancers in regional form for planning the preventive measures, this study was performed with aim to assess the epidemiologic characteristics of patients with gynecologic cancers referring to Mashhad oncologic centers in 1982-2016.

In this cross-sectional study, after evaluation of all patients’ files recorded in the last 35 years, the required data were extracted and recorded. The study period was categorized into 4 intervals: before 1990, 1991-2000, 2001-2010, and 2011-2016. The relative frequency, mean age at the time of diagnosis, and the 35-year trend were then assessed. Data were analyzed by SPSS software (version 16) and Chi-Square, Anova, and Scheffe tests. P 

Among 2953 studied patients, mean age was (49.32 ± 13.69 years. The highest mean age was observed among the patients with uterine body neoplasms (52.21±12.49) and the lowest mean age in those with ovarian cancer (46.09±16.09). The mean age at the time of diagnosis of ovarian cancer has significantly increased in the last decades (p<0.001) while decreased in those with cervical cancer (p=0.017). Cervical and ovarian cancers had the highest relative frequency during the entire study period (39.3% (1161 cases) and 36.6% (1080 cases), respectively). There was also a significant difference in the frequency of various cancers across different decades (p<0.001).

Cervical cancer was the most frequent neoplasm in this study. The mean age of diagnosis had increased in patients with ovarian cancer and decreased in cervical cancer. Since cervical cancer can be controlled by preventive measures, more attention to screening of this cancer is recommended.

Burns are tragic events with considerable mortality rates. This study was conducted to analyze the spatial pattern of burns and identify the factors associated with the burn injuries in Mashhad, Iran. 

This retrospective cross-sectional study was conducted in patients hospitalized in Imam Reza Hospital Burn Center, Mashhad, which is the only referral burn center in the northeast of Iran. Spatial generalized linear models (Poisson and negative binomial) were used to model the association between socio-economic characteristics and the incidence of burn injury. 

A total of 1044 acute burn patients (69.9% male, 30.1% female) were reviewed. Most of the burned patients were in the age group 20-29 years (41.4%). The most common cause of burn injury was flame (64.6%). The local test of spatial autocorrelation confirmed that the burns had cluster pattern in the central areas of the city and the worn-out urban texture was at higher risk of burns. The results of model showed that the percentage of worn-out urban texture (IRR =1.007; 95%CI 1.005-1.008), literacy (IRR =0.98; 95% CI 0.95-0.99), percentage of employed women (IRR =0.96; 95%CI 0.92-0.99), unemployment rate (IRR =0.92; 95%CI 0.85-0.99) and percentage of margination (IRR =1.006; 95%CI 1.005-1.008) were associated with burns. 

Based on the findings, socio-economic and environmental characteristics are associated with the incidence of burn injuries in different areas. The results of this study could be used to design burn prevention strategies, especially in the high-risk areas and groups.

Health-related quality of life is an index of the safety Patients and refers to the measure of a patient's functioning, well-being, and general health perception in each of three domains: physical, psychological, and social. The aim of this study is identify related factors with quality of life in hemodialysis patients.

In this cross sectional study, 50 hemodialysis patients of 15 to 87 years old in mashad city were participated in 2017. We used checklists which included demographic questionnaire and SF-36 Questionnaire. Descriptive and statistical tests such as mean± standard deviation for quantitative variables, Spearman correlation coefficient,Naparametric test were used.

The mean score of quality of life was 43.3±8.2 that in the physical dimension was 42.8 ± 11.9 and in the psychological dimension was 43.9 ± 10.4.The highest mean of quality of life was observed in the men( 42.5 ± 6.1) , singles ( 43.6 ± 5.4), users general vehicles (44.4 ± 8.4) and people with a level of education in the guidance school (43.5±6.7).Age (p=0.04,r=-0.3) and duration to each dialysis session(p=0.007,r=-0.2) with mean score for quality of life were significantly inversely related but the correlation did not significantly with any of the individual characteristics, laboratory factors and clinical factors. The marrage (p=0.03) and duration of each dialysis session (p=0.03) and age(p=0.04) was a significant inversely correlation with the physical dimension.

Life quality of Hemodialysis patients is low and authorities need to provide these patients with more social support and see into their welfare.

Particulate matters are of the most important air pollutants, particularly in large cities, having harmful effects on the human’s health and the environment. The present study aimed to investigate of the relationship between meteorological parameters with PM2.5 changes using AQI index in Mashhad from 2014 to 2016.

This study is cross-sectional. Data related to concentration of PM2.5 were collected from the Monitoring Center of Environmental Pollutants of Mashhad, and the meteorological parameters were obtained from the Bureau of Meteorology of Razavi Khorasan Province. Then, the obtained data were analyzed in terms of Air Quality Index using SPSS 20 and Excel software.

The study result indicated that PM2.5 concentration changes were significant from 2014 to 2016, but the trend was not constant. The average annual concentration of this pollutant in 2014, 2015 and 2016 was 29.26 ± 19.49, 25.88 ±15.89 and 30.30 ±38.86 µg/m3, respectively. Results also demonstrated a negative correlation between wind speed and PM2.5 concentration. However, there was no significant relationship between this pollutant and other meteorological parameters (temperature, relative humidity and rainfall).

Occurrence of more inversion in cold seasons, wind speed, south-east-north-west prevailing winds, and transmission of pollutants in the east and south-east industries to Mashhad are among the factors associated with the volatility of this pollutant, thereby requiring integrated management to reduce the concentration of this pollutant.

Sleep disorders include problems involving the quality, timing and amount of sleep, which cause decreased functioning and discomfort during the daytime. Considering the importance of sleep in health and quality of life and the probability of the related disorders in the elderly, this study was conducted to investigate sleep disorders and their risk factors in an elderly population covered by Mashhad University of Medical Sciences.

We conducted one of the largest population-based cross-sectional studies in an elderly population covered by Mashhad University of Medical Sciences in 2016. In this study, a total 8496 elderly people aged 60-90 years old with sleep disorders were compared with 35041 elderly subjects without complaints. Data were extracted from the Sina Electronic Health Record System. Bivariate and multivariate logistic regression analysis were carried out using the STATA ® version 14 to determine associations between independent variables and sleep disorders.

In multivariate analysis, male gender (AOR=0.58; 95% CI: 0.55-0.61), being married (AOR=0.88; 95% CI: 0.83-0.93), overweight and lightweight compared to normal weight (AOR=1.27; 95% CI: 1.21-1.34 and AOR=1.20; 95% CI: 1.04-1.38, respectively), smoking (AOR=2.22; 95% C.I: 2.05-2.40), high blood pressure (AOR=1.44; 95% C.I: 1.37-1.52), diabetes (AOR= 1.49; 95% C.I: 1.40-1.58) and depression (AOR=3.05; 95% C.I: 2.74-3.38) variable remained in the final model after adjusting for confounders.

In this study, gender, marital status, body mass index, smoking, blood pressure, diabetes and depression were the main determinants of sleep disorders. It is necessary to identify the risk factors and perform appropriate interventions to improve the sleep.

Demoralization syndrome causes loss of meaning in life, hopelessness, and sense of failure. On the other hand, understanding religious coping can affect the communication and presentation ways of religious strategies in patients with cancer. It seems that the posttraumatic growth contributes to a person's psychological adjustment to cancer. Therefore, the aim of current study was the prediction of posttraumatic growth on the base of demoralization syndrome and religious coping among cancer patients. In this descriptive study, based on the criteria for entering the study and by using convenient sampling, 167 patients referred to Reza Radiotherapy and Oncology Center in Mashhad, filled the research materials in 2018. Data were collected by a demographic questionnaire, Posttraumatic Growth Inventory (PTGI), Demoralization Syndrome Scale (DS) and the Brief Religious Coping Questionnaire (RCOPE) and analyzed by Pearson's correlation coefficient and multiple linear regression analysis using the stepwise method. There was a significant negative relationship between components of dysphoria (r= -0.306, p= 0.001), disheartenment (r= -0.296, p= 0.001) and sense of failure (r= -0.251, p= 0.001) and posttraumatic growth and there was a significant positive relationship between positive religious coping (r= 0.215, p= 0.005) and posttraumatic growth. Also, multiple linear regression results showed that totally 21 percent variance of posttraumatic growth was explained by predictive variables. According to the results, it seems that the prevention of demoralization syndrome, and using positive religious coping strategies as effective ways can help to increase posttraumatic growth in cancer patients.