جستجوی مقالات مرتبط با کلیدواژه "میلوم متعدد" در نشریات گروه "پزشکی"

Multiple myeloma is the second most common hematopoietic cancer. This disease is caused by the cancerous category of cells called plasma cells. Detecting and counting plasma cells provide valuable information for pathologists to diagnose this disease. The manual counting and considering of plasma cells are time consuming and due to the tedious nature of this process, it is subject to error. Thus, a computer-aided tool for pathologists to help in the diagnostic process can be very useful. For this purpose, this research presented a computer tool for segmentation of effective cells in multiple myeloma from microscopic images.
In proposed method, after improving the quality of the images using histogram matching and median filter, the cells were extracted using the Chan-Vese deformable model. In addition, for splitting touching cells, the Modified Watershed algorithm was used. Then, the nuclei were extracted applying the k-means clustering method.
Findings: The proposed method was evaluated on 30 microscopic images containing 370 cells. The calculated results of the proposed method showed that similarity measures, sensitivity, precision, accuracy and Dice Similarity Coefficient (DSC) respectively were 89.01%, 89.95%, 97.71%, 98.63%, and 93.86% for cell segmentation, and 91.43%, 92.48%, 96.13%, 98.53%, and 95.47% for nucleus segmentation.
In this research, a novel method was presented for segmentation and extraction of effective cells in the diagnosis of multiple myeloma cancer from microscopic images using deformable models and clustering method. The evaluation results show that the proposed algorithm have improved segmentation performance compared to the previous methods.

Extramedullary plasmacytomas are rare solitary soft tissue tumors that arise from proliferations of malignant transformed monoclonal plasma cell. Though they are closely related to multiple myelomas, they have better prognosis. The tumor is eradicated by surgery or local radiation therapy. This is a case-report study of solitary plasmacytoma tumor which involved left side maxillary sinus and underwent excisional biopsy confirmed by IHC.

POEMS is a rare systemic disease. This syndrome is usually associated with multiple mylom and skin changes. By now, it has been reported two cases of this disease in Iran.

The patient was a 53 years old male who had history of hospitalization for recurrent pulmonary infections. Additionally, he had history of hyperthyroidism and idoide treatment. In the last presentation, he was hospitalized because of low back pain. Bone marrow aspiration findings showed that the cause of low back pain is multiple mylom. In abdominal computed tomagraphy, splenomegaly was cleared that all of these systemic findings are representatives of multiple mylom and POEMS syndrome.

In this study a POEMS syndrome patient that suffering from hyperthyroidism was introduced.

A 79-year-old female came to skin clinic with an ulcer, 15×20 cm, on her left shin. The laboratory report and both the skin and bone marrow biopsies reports, showed pyoderma gangrenosum associated with multiple myeloma. The patient was referred to hematology clinic for treatment. Multiple myeloma has rarely been associated with pyoderma gangrenosum. Multiple myeloma should be investigated in patients with paraproteinemia and pyoderma gangrenosum.