جستجوی مقالات مرتبط با کلیدواژه "هیپرلیپیدمی" در نشریات گروه "پزشکی"

 Curcumin has potential anti-inflammatory effects. The aim of this study was to investigate the protective effect of curcumin against cardiac ischemia -reperfusion injury in rats fed a high-fat diet.

 In this experimental study, male Wistar rats were divided into four groups: control (C), high-fat diet (H), curcumin 100 (HyperC100, 100 mg/kg) and curcumin 200 (HyperC200), with the last two groups receiving oral curcumin daily for 3 weeks.
The rats were fed a high-fat diet for 7 weeks to induce obesity. After anesthesia, hearts were removed and placed on the Langendorff perfusion system andbegan beating. After 20 minutes of stabilization, 35 minutes of ischemia and 60 minutes of nutrient fluid reflux were performed. During this interval, ventricular (LV) functional indices including LVSP, LVDP, LVEDP and +dp/dt were recorded. The relative size of the infarction was measured by using 2,3,5-triphenyltetrazolium chloride staining.

 Hyperlipidemia caused dysfunction with changes in ventricular parameters, but curcumin could to improve some LV contractile parameters such as systolic pressure and increase diastolic pressure (P≤0.05). Curcumin could not significantly reduce the infarct size.

 Curcumin may have an cardio protection effects against ischemia/reperfusion injury in normal and hyperlipidemic rats.

Cinnamon is a plant containing anti-inflammatory, anti-apoptotic, and antioxidant substances. Previous studies have revealed the reducing effects of obesity and hyperlipidemia and, on the contrary, the reinforcing effects of cinnamon on fertility. Therefore in this study the effect of the hydroalcoholic extract of cinnamon on Body Mass Index (BMI) and gene expression of cation channel of sperm (CatSper) in male Wistar rats receiving high-fat diets was investigated.

Thirty-six male rats were divided into six groups. Control group received normal diet and no treatment. The five other groups received high-fat diet for eight weeks. The diet control group received only high-fat diet, the vehicle group received carboxymethyl cellulase 0.5% (5 mg/kg), the lovastatin group received 10 mg/kg lovastatin, and the cinnamon groups received 130 and 260 mg intra peritoneum for six weeks daily. BMI was measured at the end of the study. The expression levels of Catsper genes were also evaluated using Real-Time PCR. Data were analyzed with SAS software version 9.1 using one-way analysis of variance (ANOVA) and Duncan tests (p<0.05).

The hydroalcoholic extract of cinnamon significantly reduced BMI (p<0.05). The expression level of Catsper1-4 genes decreased in the model and vehicle groups compared to the control group (p<0.05); however, the expression level of Catsper1-4 genes increased in the cinnamon and lovastatin groups compared to the control group.

Cinnamon as a pretreatment has beneficial and reducing effects on BMI. Moreover, in pretreatment with cinnamon, the increased expression of Catsper1-4 genes is observed.

In the present study the effects of Averrhoa carambola fruit hydro-alcoholic extract on hepatic tissue, liver enzymes, and serum lipids were investigated in rats submitted to a high-fat diet.

In this experimental study, 30 male Wistar rats were randomly divided to 3 equal groups as follows: (1) control, (2) rats fed a high-fat diet and (3) rats receiving a high fat diet and hydro-alcoholic extract of Averrhoa carambola (A. carambola) at a dose of (200 mg/kg bw). Rats received a high-fat diet for one month. Then, two rats were selected from each diet group and hyperlipidemia was confirmed by measurement of serum triglyceride and serum cholesterol levels. After confirming hyperlipidemia, rats of group 3 were orally treated by Averrhoa carambola (200 mg/kg bw) for 21 days. At the end of the experiment, serum liver enzymes, serum cholesterol and triglyceride levels were assayed. Afterward, for histopathological investigation, hepatic tissue samples were prepared and routine tissue processing protocol was performed.

The administration of Averrhoa carambola fruit extract significantly reduced serum triglyceride and cholesterol when compared with the hyperlipidemic group (P < 0.05 and P < 0.001 respectively). Serum ALT and AST in rats that received Averrhoa carambola fruit extract significantly decreased compared to hyperlipidemic group (P< 0.05). In the histopathological examination, degeneration, vacuolation and intra-cytoplasmic accumulations in the treated group were improved in comparison with the hyperlipidemic group.

These results showed that the Averrhoa carambola fruit extract can protect against hyperlipidemia- induced liver damage in rats.

Tamarix dioica is a medicinal herb in Sistan and Baluchestan, which has antidiabetic and antioxidant properties. This research aimed to investigate the effects of the hydro-alcoholic extract of this plant on liver damage caused by a high fat diet.
 
In this experimental study, 30 males adult Wistar rats, were randomly divided into 3 equal groups. The first group or the control group received a normal diet. The second group (hyperlipidemic group) received a high fat diet (HFD) for 30 days, and the third group received a high-fat diet for 30 days. In the following, the rats orally received hydroalcoholic extract of tamarix dioica (dose, 200mg/kg bw) for 30 days. serum liver enzymes. At the end of the period, blood samples were taken from the heart of the rats to assess liver enzymes and serum levels of cholesterol and triglyceride. After euthanasia, liver tissue samples, were taken and examined under a light microscope after staining with hematoxylin-eosin.
 
Administration of the extract of Tamarix dioica (200mg/kg bw), significantly reduced serum cholesterol and triglyceride levels compared to the hyperlipidemic rats with no treatment (p<0.001). Furthermore, the treatment with the extract of Tamarix dioica decreased the levels of serum alanine aminotransferase (ALT) and serum aspartate aminotransferase (AST) compared to the untreated hyperlipidemic rats (p<0.01). In histopathological evaluation, fat accumulation in cells, was significantly lower in Tamarix dioica treated rats compared to the hyperlipidemic rats.
 
Administration of Tamarix dioica extract can reduce the liver damage induced by high fat diet.

Increasing blood sugar and hyperlipidemia in diabetic patients may lead to enhance late complications of diabetes. So, the aim of this study was to evaluate the herbal combination effects of securigera securidaca, vaccinium arctostaphylos, citrullus colocynthis and coriandrium sativum on triglyceride of pre-diabetic elderlies.
In a single-blind randomized controlled trial, 60 pre-diabetic persons aged 60 to 70 years with triglyceride level of 180-250 mg/dl were selected. They were divided in two groups (drug and placebo) randomly. The drug group patients recieved diet with 500 mg capsules of herbal blend once a day and the placebo group in the same period received diet and placebo capsules (500 mg flour). Their triglyceride levels in 2 groups were evaluated after 30 days.finally, SPSS software 18 was used to data analysis.
In this study, comparing the mean triglyceride and the mean changes in triglyceride had no significant statistical diffrences before and after the intervention, also comparing the mean triglyceride levels before and after the intervention, separetly Translation errorin vegetable capsules group (drug) or placebo had no significant statistical diffrences.
Regarding to the ineffectiveness of of 30-day intervention of herbal blend on elderlies’s triglyceride, it is recommended to perform more study regarding to drug dose and time of consumption of these herbal medications.

Hyperlipidemia and elevated serum total cholesterol is one of the greatest risk factors contributing to prevalence and severity of cardiovascular complications like coronary heart diseases, including atherosclerosis and death. To clarify the anti-hyperlipidemic effect of Artemisia dracunculus essential oil (ADEO), the present experimental study was designed.
The EOAD was extracted by clevenger apparatus using hydrodistillation. Hyperlipidemia was induced by giving high cholesterol (2%) diet in standard rat chow diet for twenty-one days. Animals were randomly divided into 6 groups (there were 6 rats in each groups). The groups of rats selected for the study were treated orally with lovastatin (10 mg/kg) and EOAD (15–60 mg/kg) daily for the two weeks.
EOAD did not show significant difference in serum cholesterol (TC) and triglycerides (TG), but these values were lowered significantly (P The present work indicated that essential oil of A. dracunculus could not prevent dyslipidemia that occurred in rats following feeding of high cholesterol diet in both dose-and time-dependent manners. However, it was affected HDL level and athrogenic index. Further studies are needed to characterize the effects of A. dracunculus in the prevention and treatment of atherosclerosis.

Hyperlipidemia is a progressive worldwide metabolic disorder. The aim of the present study was evaluation of effects of Salvia shariffi and Salvia virgata hydroalcoholic extracts on some serum biochemical parameters in hyperlipidemic male rats.
In this experimental study, 40 male Wistar rats were randomly divided into 4 equal groups including control, hyperlipidemic rats, and hyperlipidemic rats treated with S. virgata and S. shariffi hydroalcoholic extracts (200 mg/kg bw). High-fat diet was administered to rats for one month. Then, hyperlipidemia was confirmed by measurement of serum triglyceride and cholesterol levels and the extracts were orally treated to the groups for 21 days. Finally, serum cholesterol and triglyceride levels and hepatic enzymes were measured and the obtained data were analyzed using one-way ANOVA and Tukey's post hoc test.
Comparing to the hyperlipidemic group, the serum levels of cholesterol, triglyceride, and low-density lipoprotein were significantly reduced in the treated groups but this reduction was brilliant in the group treated with S. shariffi (P Both extracts could improve lipid profile and liver enzymes in hyperlipidemic rats but this improvement was more pronounced in the S. shariffi treated group.

ApoAI, is the main protein of HDL and its gene is a member of apoAI-CIII-AIV gene cluster on chromosome 11q23-q24. In some studies, association of PstI polymorphism with dyslipidemia has been reported. This study was designed to investigate the frequency of rare allele (P2) of apoAI gene PstI polymorphism and its association with serum lipids levels in an Iranian population (Semnan city).
In a case-control study genomic DNA was extracted from whole blood of 76 Iranian hyperlipidemic patients [total cholesterol (TC) > 200 mg/dL, triglyceride (TG) > 150 mg/dL] and 75 healthy control subjects (TC The frequencies of the PstI polymorphism minor allele (P2) were 22.14 and 14.7 in the case and control groups respectively (P>0.05). In the case group, patients with P2P2 genotype had lower serum HDL-c and apoAI, compared those with P1P1and P1P2 genotypes (P> 0.05).
Considerably, the presence of the rare P2 allele was not associated with lipid levels in the studied population. The association between the polymorphisms and dyslipidemia is quite complicated. We propose evaluation of PstI polymorphism with other polymorphic sites in the apoAI-CIII-AIV gene cluster

Barberry has various antioxidant compounds and hypolipidemic properties. This study was carried out to compare the effect of Barberry's aqueous extract and Lovastatin on reduction of liver indices enzymes level in hyperlipidemic mice serum treated with high fat diet.
In this study, 60 male mice were divided randomly into 4 groups. Control group was not feed. Negative control group which were hyperlipidemic and considered as the main control group. Positive control group treated with high fat diet and received specific dose of Lovastatin at the same time. The treated group fed with high fat diet and aqueous extract of B.vulgaris (80 mg/kg). At the end of 30 days, blood sampling was done from the heart of the mice and the level of liver enzymes was measured. Data were analyzed using statistical analysis.
Based on the results, the level of ALP enzyme increased in the group treated with Barberry aqueous extract compared to the negative control group (p≤0.05), whereas the level of ALT and AST enzymes decreased (p≤0.05) which was similar to Lovastatin effect. On the other hand, there was no significant difference in the level of enzymes between positive control and treated groups.
Overall, despite the fact that B. vulgaris aqueous extract and Lovastatin had similar effect on reduction of the liver enzymes level, the use of B. vulgaris aqueous extract is preferred due to the fewer side-effects.

Due to high prevalence of diabetes with hyperlipidemia and associated high risk of cardiovascular disease, much interest exists for safe medications including medicinal plants. Considering traditional use of Citrullus colocynthis L. (C. colocynthis) for treatment of diabetes and hyperlipidemia despite toxicity, clinical evaluation of safety and efficacy of the processed C. colocynthis fruit is necessary. In this clinical trial the safety and efficacy of the processed C. colocynthis fruit in hyperlipidemic type II diabetic patients were evaluated. 60 hyperlipidemic type 2 diabetic patients were randomly allocated to C. colocynthis and placebo groups, but only 28 patients in each group completed the study. The patients in C. colocynthis and placebo groups were treated with processed C. colocynthis (100 mg) and placebo capsules (100 mg) three times a day respectively for 1 month. The fasting blood glucose, cholesterol, LDL, HDL, and triglyceride levels as primary outcome and aspartate transaminase, alanine transaminase and creatinine levels as secondary outcome were measured in both groups at the baseline and the endpoint. In the C. colocynthis group fasting blood glucose, cholesterol and LDL levels were significantly reduced at the endpoint compared with the baseline. There were no significant changes in any blood parameters in C. colocynthis group compared with placebo at the endpoint. There were no gastrointestinal, liver and kidney function adverse effects during the study in both groups. The results suggest that processed C. colocynthis fruit extract may be a safe anti-hyperglycemic and anti-hypercholesterolemic agent in hyperlipidemic type II diabetic patients.

Hyperlipidemia is a major risk factor for atherosclerosis and cardiovascular incidents. Abnormalities in lipoproteins and lipids profile are common in patients with pediatric idiopathic nephrotic syndrome and may contribute to atherosclerosis. Prescription of lipid lowering agents such as statins because of myopathy and growth disorders, are not recommended in child-aged groups. However, there isn’t any investigation on carnitine effects on lipids profile of patients with childhood nephrotic syndrome which is the propose of our study. In this case-control study, case group included 16 patients in 2-12 years of age with steroid resistant nephrotic syndrome, receiving prednisolon, cyclosporine and carnitine (25mg/kg/day) within a 3 months period and control group included 17 age and sex matched patients, receiving standard treatment (prednisolon, cyclosporine), were compared. In both groups, biochemical parameters like triglyceride, cholesterol, VLDL, LDL, HDL, BUN, creatinine and serum albumin were measured. At the end of the study period, L-carnitine treated group showed no significant difference in the biochemical markers compared with the control group (P-values>0.05). Our study indicates that oral administrations of L-carnitine with the dose of 25 mg/kg/day did not have any effects on lipoprotein profile of persistent childhood nephrotic syndrome.

Complications associated with atherosclerosis are the most common cause of human mortality. Hyperlipidemia is an important risk factor for atherosclerosis. In fact, a decline in cholesterol concentration decreases the incidence of coronary artery diseases by approximately 50%. Considering the use of herbal medicine as one of the earliest modes of treatment, this study aimed to determine the effect of ginger on reducing lipid level in humans. In this study, 90 patients with hyperlipidemia were randomly allocated to 3 groups of 30 subjects. The first group only received anti-hyperlipidemic medications, the second group was given anti-hyperlipidemic and placebo medications, and the third group received ginger in addition to anti-hyperlipidemic medications for 7 weeks. Fasting blood sugar (FBS), blood pressure, and serum lipid were evaluated before and after the intervention. FBS, triglyceride, cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels were not significantly different among the three groups before the intervention. However, after the intervention, FBS was different between the first and third groups. Moreover, triglyceride level in the third group was significantly different from those reported in the first and second groups. Also, HDL in the third group was significantly different from those of the first and second groups. Given the significant effects of ginger on blood sugar and serum lipid profile, we recommend ginger for controlling hyperlipidemia, hyperglycemia, and hypertension.

Dyslipidemia is a common disorder and one of the major causes of the atherosclerosis development and progression in hemodialysis patients.Timely diagnosis and treatment of dyslipidemia can reduce mortality and morbidity of cardiovascular disease and protect the remaining function of kidneys in patients withchronic renal failure. This study was performed with the objective of evaluating the frequency of dyslipidemia and its accompanying factors in hemodialysis patients. In a descriptive cross-sectional study, 182 patients with chronic renal failure referred to hemodialysis units of Baqiyatallah and Shahid Chamran hospitals, Tehran in 2012 were studied. Fordata collection, in addition to demographic questionnaire, serum levels of cholesterol, triglyceride, HDL and LDL were measured. Data analysis was done using Chi-square, independent t-test, and one-way ANOVA. The significance level was considered to be p<0.05. In this research, 8.2% of the patients had hypercholesterolemia, 26.4% hypertriglyceridemia, and 6.8% LDL level more than 130. In half of the patients, serum HDL was less than 35. A significant relationship was observed betweendyslipidemiaand variables of gender (p=0.001), duration of hemodialysis (p=0.004), education level (p=0.005), and weight (p=0.007). Dyslipidemiahas a high prevalence in hemodialysis patients, especiallypatients with low literacy and obesity. So that, at least one of the components of lipid profilesis abnormalin more than 80% of hemodialysis patients. Therefore, planning to improve life style and provide training on proper nutrition and physical activity is recommended as one of the principles of care in hemodialysis patients.

We are aware of limited data about the effects of purslane on diabetes. Earlier studies have mostly indicated the beneficial effects in animal models. This study aimed to evaluate the effect of purslane seeds on glycemic status and lipid profiles of type 2 diabetic patients. This cross-over randomized controlled clinical trial was conducted on 48 diabetic patients. Participants were randomly assigned to receive either 10 g/d purslane seeds with 240 cc low-fat yogurt (intervention group) or only 240 cc low-fat yogurt (as control group) for 5 weeks. After a 2-week washout period, subjects were moved to the alternate arm for additional 5 weeks. At baseline and end of each phase of study, fasting blood samples were collected to quantify plasma glucose levels as well as serum insulin and lipid profiles. Mean age of study participants was 51.4±6.0 y. We found a significant reduction in weight (-0.57 vs. 0.09 kg, P=0.003) and BMI (-0.23 vs. 0.02 kg/m2, P=0.004) following purslane seeds consumption. Despite a slight reduction in fasting plasma glucose levels (-2.10 vs -2.77 mg/dL, P=0.90), we failed to find any significant effect on serum insulin levels and HOMA-IR score after purslane seeds intake. Furthermore, purslane seeds consumption decreased serum triglyceride levels (-25.5 vs. -1.8 mg/dL, P=0.04) but could not affect serum HDL-, LDL- and total-cholesterol levels. We observed significant reduction in systolic blood pressure (-3.33vs. 0.5 mmHg, P=0.01) and a borderline significant decrease in diastolic blood pressure (-3.12 vs. -0.93 mmHg, P=0.09) after purslane intake. In conclusion, consumption of purslane seeds for 5 weeks in type 2 diabetic patients might improve their anthropometric measures, serum triglyceride levels and blood pressure. Further studies are required to determine the appropriate dosage for these patients.

Coronary artery diseases are one of the main causes of mortality and morbidity. This study was done to determine the prevalence of risk factors for coronary artery diseases in patients referred to angiography center in Sari، Northern Iran. This descriptive study was performed on 2540 patients referred to angiography center in Sari city، northern Iran، during 2005-10. Risk factors including diabetes، hypertension، hyperlipidemia، smoking، Family history، CRP and also ECG changes، type and number of involved artery and the severity of vascular involvement were recorded for each patient. Hypertension، hyperlipidemia، diabetes، smoking were seen in 40. 8%، 40. 5%، 29. 1%، 12. 5% of patients، respectively. Positive family history and CRP were found in 10% and 3. 4% of the patients، respectively. 23. 8% of patients had abnormal ECG. One، two and three vessel diseases were observed in 26. 5%، 48. 3%، 48. 3% of cases، respectively. Left anterior descending artery constriction was seen in 75. 8% and 80. 4% of males and females، respectively. A significant relationship was found between diabetes and left coronary circumflex (P<0. 04) and left anterior descending artery (P<0. 03) constriction. Diabetes، hypertension، hyperlipidemia، smoking، family history، abnormal ECG are among the risk factors of coronary artery diseases in this area.

Androgenetic alopecia (AGA) is the most common type of progressive balding that appears with early loss of hair، chiefly from the vertex. There has been significant relationship between AGA with coronary artery disease and related risk factors، such as hypertension in some studies. The aim of this study is to investigate the association between androgenetic alopecia with hyperlipidemia.

This cross-sectional study was performed on 112 patients with vertex type AGA (in male grade 3 or higher Hamilton- Norwood scale، and in female grade 2 or higher Ludwig scale) (study group) and 115 persons age and sex matched، with normal hair status (Normal group). None of participants had diabetes mellitus، hypothyroidism، liver disease، kidney disease and none of them had history of smoking and using drugs with effect on serum lipids. They were 20-35 years old and their body mass index were 20-30. Blood samples were obtained following 12 hours fasting status and serum levels of triglyceride (TG)، cholesterol، high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were determined using standard laboratory methods. Total cholesterol greater than 240 or TG greater than 200 or LDL greater than 160 or HDL less than 40 in men or HDL less than 50 in women were considered hyperlipidemia.

In androgenetic alopecia group 46. 4% and 47% of normal group were female. Mean (±SE) of total cholesterol (172. 4±3. 1، 148. 8±3. 1، P< 0. 001)، TG (133. 6±5. 5، 88. 3±4. 3، P< 0. 001)، LDL (96. 4±2. 9، 84. 9±2. 7، P= 0. 004) and HDL (54. 9±2. 0، 45. 5±0. 9، P< 0. 001) in AGA patients were higher than normal group. %46. 4 of patients and %52. 2 of controls had hyperlipidemia. Relationship between AGA with hyperlipidemia was not significant (P> 0. 05).

The findings showed that there is no relationship between AGA and hyperlipidemia. Regarding to high levels of total cholesterol، LDL and triglyceride in AGA patients، it seems that، AGA increases risk of coronary heart disease. To determine a definite association between AGA and hyperlipidemia more studies are recommended.

Stroke is the third leading cause of death in the world. Risk factors for stroke in young adults are different from adults، this study aimed to determine the frequency and risk factors for strokes in patients 15-45 years old. In this cross-sectional study، hospital records of all patients 15-45 years old with stroke who were hospitalized in Ayatollah Roohani hospital during 2009-2010 by using a checklist including demographic characteristics، time of stroke onset، type of stroke and risk factors were extracted and the collected data were analyzed. The average age of patients was 38. 09±6. 11 years that 34 patients (52. 3%) were male and the rest were female. The most common type of stroke was ischemic in 61 cases (93. 8%)، that the most common of them was embolic in 38 (58. 8%) and hemorrhagic strokes (6. 2%)، and 10. 8 % were as a TIA (transient ischemic attack). Among the risk factors، hypertension was in 23 cases (35. 4%)، heart disease was in 20 cases (30. 8%) including ischemic heart disease in 7 cases (%10. 8)، mitral stenosis، patent foramen ovale each in 6 cases (9. 2%) and the others were different other cardiologic etiologies. Alcohol and substance abuse in 18 cases (28. 1%)، hyperlipidemia in 15 cases (23. 1%)، diabetes in 13 patients (20%)، hematologic disorders in 12 cases (18. 5%) that 6 cases (9. 2%) of them had hypercoagulable state. Miscellaneous causes were in 13. 8% cases and no risk factor found in 7. 7% cases. The most common type of stroke was ischemic stroke and hypertension، cardiovascular disorders، drug and alcohol abuse، hyperlipidemia and diabetes were the most common risk factors associated with stroke.

Dyslipidemia is one of the major causes of the production and progression of atherosclerosis in hemodialysis patients. Vitamin C is able to improve dyslipidemia by reducing an oxidative stress. The aim of this study was to evaluate the effect of vitamin C supplementation on dyslipidemia in hemodialysis patients. In a randomized، double-blind clinical trial، 160 patients with chronic renal failure were studied. They were divided into three groups (intervention، control and witness). In an intervention group، 250 mg from vitamin C was injected، three times weakly at the end of each dialysis session via the intravenous route، for 8 weeks. In the control group same amount of placebo saline was injected and in the witness group no intervention was performed. Required laboratory parameters including serum total cholestrole، triglyserid and HDL were measured at the beginning and end of the intervention. In order to analyze the data، SPSS statistical software was used، and test Chi square and ANOVA were performed. P value less than 0. 05 is considered statistical significance. No significant differences were observed in the serum levels of cholesterol، triglyceride and HDL between groups before and after the intervention. The results of this study demonstrated that 250 mg intravenous vitamin C did not change serum levels of cholesterol، triglyceride and HDL.

Allium latifolium has polyphenolic compounds with power antioxidant properties which reduce serum lipids. Phosphatidate phosphohydrolase (PAP) is a key enzyme in controlling the synthesis of glycerophospholipids. The aim of this study was to determine the effect of the hydroalcoholic extract of Allium latifolium on the liver PAP and serum lipid profile in hyperlipidemic rats. In this experimental study، 40 male rats were randomly divided into 5 groups (8 in each group). Group I (normal) received standard diet، group II received cholesterol and oil diet (without treatment group)، and groups III and IV were the rats which received cholesterol (Chol) and oil plus 150 and 300 mg/kg bw Allium latifolium extract، respectively. Group V were the rats which received cholesterol and oil diet plus 30 mg/kg bw gemfibrozyl. At the end of the study، liver PAP activity، liver triglycerides (TG) and cholesterol، and serum lipoprotein levels were determined and compared. In group II، liver PAP activity showed a significant reduction (p<0. 05) compared to other groups. In groups III and IV (the rats which received Allium latifolium extract)، the liver Chol and TG، serum HDL-C، TG، total Chol، and VLDL (Very Low Density Lipoprotein) concentrations showed a significant reduction (p<0. 05) compared to group II (the rats without treatment). In group IV، serum total cholesterol indicated a significant elevation (62. 30%) with respect to group III (p<0. 05). The consumption of Allium latifolium in the low dose can reduce the side effects of hyperlipidemia such as elevated serum Chol and TG.