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Aging and wrinkles on the face and neck are natural processes throughout a person's life. On these days, there are various techniques to treat these facial lines. The non-invasive facelift technique is suggested considering the risks and effects of different cosmetic procedures. This research collected information about using polymer threads for lifting the face and treating ptosis from authentic scientific texts published in databases such as PubMed, Google Scholar, Science Direct, and Web of Science. The investigations showed that when placed correctly, biodegradable polymer threads cause skin irritation and promote collagen formation, so that’s interesting for patients and doctors. Patients undergoing a facelift with polymer threads experience fewer complications than those undergoing traditional methods. Despite the low side effects of this method, some patients have opted to remove the threads after the lift due to dissatisfaction with their appearance. Threads with superficial spines and biodegradability are considered popular and attractive for lifting the soft tissue of the face due to their quick recovery and low cost. Different types of absorbable threads are available in the market, each with different compositions and have different designs depending on the place of use. This review study will discuss biodegradable polydioxanone (PDO), polycaprolactone (PCL), and polylactic acid (PLLA) yarns.

Wound healing is a complex process and known as one of the most important challenges in medicine, which imposes a significant financial burdens on patients and healthcare systems. It has been estimated that chronic wounds as a whole cost the medical system over US$12 billion per year. Therefore, the development of innovative therapeutic strategies for skin wound healing is very important. Over the years, different conventional therapeutic strategies such as debridement, skin grafting, pharmacological agents, topical formulations, wound dressings, and bioengineered skin substitutes, have been used extensively as the safe and effective methods for wound therapy. Moreover, in recent years advanced biomedical technologies, including nanomaterial-based therapies, stem cell applications, 3D bioprinting, platelet-rich plasma (PRP), microRNAs, and hyperbaric oxygen therapy, have been utilized to promote wound healing and restore normal skin function. In this study, modern and up-to-date available therapeutic strategies for healing and management of chronic wounds have been investigated.

 Stress is a psychological pressure that affects an individual's physical health, including skin health. Skin disorders can also exacerbate stress, creating a vicious cycle in which stress and skin diseases reinforce each other. The aim of this study was to determine the level of stress in patients with fungal skin infections and compare it with healthy individuals.

 This descriptive-analytical study was conducted with the participation of 152 patients with fungal skin infections referred to Ardabil medical centers and 148 of their companions as a healthy group in 2023. The sampling method was available sample. A total of 300 individuals were selected through convenience sampling. The Perceived Stress Scale by Cohen was used to assess stress levels. After completing the questionnaires by both groups, perceived positive and negative stress levels were evaluated. Data were analyzed using the independent t-test and SPSS Statistics for Windows, version 26.0 (SPSS Inc., Chicago, Ill., USA).

 A total of 152 volunteers with fungal infections, including 108 women and 44 men, aged 18 to 48, and 148 healthy volunteers, including 76 women and 72 men, participated in the study. The mean (SD) age of the patient group was 31.5 (5.0) and the healthy group was 31.2 (6.6) years. In the patient group, the mean (SD) of perceived negative stress was 23.6 (0.3) higher than in the healthy group 22.8 (0.2) (P=0.01). There was no difference in the level of perceived positive stress between the healthy 17.0 (3.8) and the patient 16.7 (5.4) groups.

 The level of negative perceived stress was higher in patients with fungal skin infections compared to healthy individuals. Psychological interventions aimed at training patients in perceived stress management appear to be necessary.

Curcuma zedoaria, an aromatic plant from the ginger family, has gained attention for its medicinal properties. In traditional medicine, Curcuma zedoaria has been used as an anti-inflammatory, antibacterial, antifungal, and analgesic. Recent scientific research has revealed significant benefits of Curcuma zedoaria for skin health. Curcuma zedoaria contains curcumin, a powerful anti-inflammatory compound that can help reduce skin inflammation, redness, and swelling. This makes Curcuma zedoaria a suitable option for treating acne, eczema, and psoriasis. Curcumin in Curcuma zedoaria also possesses strong antioxidant properties that can help protect the skin from damage caused by free radicals. Additionally, curcumin can promote collagen and elastin production, which are essential for wound healing. The antimicrobial properties of curcumin can aid in combating bacteria and fungi that cause skin infections. Curcuma zedoaria also exhibits anticancer properties that can help prevent the growth of skin cancer cells. Therefore, Curcuma zedoaria is a natural and safe plant that can help treat a wide range of skin problems. This review article explores the various benefits of Curcuma zedoaria for the skin.

Curcumin is the active ingredient of the turmeric plant (Curcuma longa) from the ginger family (Zingiberaceae). The medicinal properties of this plant have been known and used for thousands of years. Today we know that turmeric is a rich source of two main products: polyphenols (curcuminoids) and essential oils. Curcumin is the main natural polyphenol in turmeric rhizomes. Research has shown that curcumin has strong anti-inflammatory and antioxidant properties. These effects of curcumin have caused this compound to be used as an effective supplement in the treatment of various diseases such as; Pain, diabetes, addiction, central nervous system diseases, skin diseases, cardiovascular diseases, etc.

The present study reviewed related investigations up to 2024 by searching keywords such as turmeric, curcumin, curcumin with skin diseases, cardiovascular diseases, digestive diseases, central nervous system diseases, addiction, lung diseases, skin diseases, cancerous tumors, cancer, diabetes, and aging; Cheched in PubMed databases. Among the collected articles, the articles that were most related to the goals of writing this article were selected and studied.

Research shows that curcumin is a potent antioxidant and anti-inflammatory and a tolerable compound in humans. The permissible daily intake of curcumin based on JECFA (Joint FAO/ WHO Expert Committee on Food Additives) and EFSA (European Food Safety Authority) is up to 3 mg/ kg. Of course, in various studies, daily consumption of up to 12 grams of safe and non-toxic curcumin has been mentioned. Considering that curcumin is a very effective compound in the treatment of many diseases and is used as a supplement in some diseases in our country; And on the other hand, the therapeutic effect of this combination has been proven in various diseases; In this review article, we examined the effect of curcumin in the treatment and improvement of various diseases. It should be noted that so far, no article has been presented that examines the effect of curcumin on various diseases.

Psoriasis is a common skin disease that presents with papulosquamous lesions (scaly papules and plaques) and can have psychological and physical consequences. Due to the anti-inflammatory role of vitamin D, studies have been conducted on the relationship between serum levels of this vitamin and psoriasis. In recent years, conflicting results have been obtained, all of which emphasize the importance of investigating this issue. This study aimed to investigate the relationship between serum 25-hydroxy-vitamin D levels and psoriasis.

We conducted a case-control study with psoriasis patients from Vasei Hospital's dermatology clinic and healthy people from Sabzevar Blood Transfusion Center in Iran. Patients with chronic psoriasis (more than 6 months) aged 18 to 65 years were included in the study regardless of the type of psoriasis. This study had a sample size of 177 people (88 cases, and 89 controls). The data collection methods were a questionnaire and blood samples. In both groups, the amount of 25-hydroxy-vitamin D was measured by ELISA method.

This study recruited 177 individuals: 78 (44.10%) males and 99 (55.90%) females. The mean age in the case group was 36.95±13.30 and in the control group, it was 21.34±12.60 years. The mean vitamin D levels had no significant difference between the case (19.68±13.60) and the control groups (21.34±12.60) (P>0.05).

The findings of this study showed that there was no significant difference in vitamin D levels between the case group and the control group, which did not support the hypothesis that vitamin D deficiency is associated with psoriasis.

Chitosan biopolymer, due to its antimicrobial, anti-inflammatory, and antioxidant properties, has become an ideal candidate for use in a wide range of cosmetic products and has opened up new horizons in the design of cosmetic formulations. The ability of this polymer to electrostatically interact with negatively charged surfaces (such as damaged skin) leads to the formation of polymeric films and ultimately imparts smoothness and moisture to cosmetic products. This review article revisits the potential of chitosan and its derivatives as raw materials in cosmetic and skincare products.

The skin, as the outer layer, protects the body against external factors. Wounds can negatively affect its performance. Wound healing includes three stages of inflammation, proliferation, and regeneration, which begin immediately after injury. Also, some factors such as infection, obesity and diabetes can disrupt the natural healing process that leads to chronic wounds. Various surgical and non-surgical treatments have been used to manage chronic wounds, including hyperbaric oxygen therapy, ultrasound therapy, laser therapy, and skin grafting. These treatments have advantages and disadvantages. Recently, stem cells have been used as a surgical treatment for chronic wound healing. Stem cells are highly proliferative cells that can maintain their ability to divide and regenerate for a long time. Among the different types of stem cells, MSCs have many advantages such as ease of harvest, availability, and multilineage differentiation capacity for cell therapy. In addition, they showed some properties that could be useful in the clinical application of ASCs, including angiogenesis, immune system modulation, and improved tissue regeneration. This study was conducted by collecting data from reliable scientific sources from April 1401 to January 1402 at the Research Institute of Neurosciences, Brain and Spinal Cord Injury Research Center of Tehran University of Medical Sciences. Several studies have shown that ASCs can be a suitable candidate for wound healing due to their special characteristics. The purpose of this review is to discuss the use of ASCs in wound repair and healing as a new strategy in the treatment of skin problems.

Cosmetic dermatology has seen significant advancements in developing new materials and techniques to enhance skin beauty and combat signs of aging. One notable development is creating and analyzing fillers made by combining hyaluronic acid and polycaprolactone. This innovative filler type has gained popularity due to its unique properties, exceptional skin rejuvenation capabilities, and effectiveness in facial contouring. This study gathered information on dermal fillers and the effects of using hyaluronic acid and polycaprolactone by referencing papers from various databases such as Civilica, PubMed, Google Scholar, Science Direct, and SID. The authors conducted a study to explore the benefits and drawbacks of utilizing hyaluronic acid and polycaprolactone and their impact on filler durability and injectability. Research conducted by experts and studies on cosmetic fillers has highlighted the positive effects of hyaluronic acid and polycaprolactone, two powerful substances widely discussed in the beauty industry. Further research could improve the understanding and utilization of hyaluronic acid/polycaprolactone fillers, enhancing skin cosmetic treatments and increasing patient satisfaction.

Decellularized extracellular matrix scaffolds, with a three-dimensional structure and natural bioactive compounds, can mimic the natural conditions of the body. This study aimed to decellularize, characterize, and explore the potential use of chicken skin as a scaffold in tissue engineering.

In this experimental study, the chicken skin was decellularized with a combination of physical (agitation) and chemical [ionic detergent sodium dodecyl sulfate (SDS)] methods. DNA content, histological characteristics, morphology, mechanical properties, biocompatibility, blood compatibility, swelling, water retention capacity, and contact angle of the scaffold were investigated.

The decellularization of chicken skin was confirmed through DNA content assay and tissue staining. Electron microscope images demonstrated the preservation of scaffold morphology. Besides, the mechanical strength of the decellularized tissue was largely maintained. The prepared scaffold exhibited non-cytotoxic properties and showed acceptable compatibility with blood. Additionally, the scaffold displayed promising characteristics in terms of swelling, water retention capacity, and contact angle.

Our study's findings indicate that chicken skin, as a readily available material, is biocompatible, hemocompatible, and capable of retaining moisture. Therefore, it can be considered a suitable candidate for scaffold preparation in future tissue engineering research.

Caviar, a rich source of nutrients, has long been recognized as a luxurious and nourishing food. In recent years, research has shown that caviar can also be beneficial for cosmetic and therapeutic purposes. The aim of this study is to explore the various applications of caviar-derived fatty acids, proteins, and peptides in skincare products.

Relevant scientific databases such as PubMed, Scopus, and Science Direct were searched using keywords including "caviar," "fatty acids," "proteins," "peptides," "skin," and "cosmetic and therapeutic applications." Studies published in English within the last 10 years were reviewed and summarized.

Studies have demonstrated that the polyunsaturated fatty acids present in caviar, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possess anti-inflammatory, antioxidant, and anti-aging properties. Caviar is a rich source of various proteins and peptides with diverse biological activities. Some of these proteins and peptides can act as moisturizers, firming agents, anti-inflammatories, and antimicrobials.

Due to its abundance of fatty acids, proteins, and nourishing peptides, caviar can be utilized as an effective ingredient in skincare formulations. These natural compounds can contribute to improving skin health, enhancing its radiance and vitality, and preventing signs of agin

Cryotherapy, which causes inflammation, is one of the methods used in treatment of warts. Including a topical steroid in a regular wound care regimen slows the course of damage and promotes re-epithelialization. The purpose of this study was to assess the therapeutic efficacy of topical betamethasone valerate on inflammation after cryotherapy in patients with warts compared to placebo.

Twenty people were included in a double blind clinical trial. Cryotherapy was used on both sides of the body to treat the lesions. Following cryotherapy, topical betamethasone was applied to the lesions on one side, while placebo ointment was applied to the lesions on the opposite side. The patient's symptoms were documented during four visits. To assess pain intensity, the visual pain scale (VAS) was used. Finally, treatment evaluation was scored during these four sessions. SPSS V16 was used to analyze the data.

None of the samples at the end of the study had hypertrophic or atrophic scars and depigmentation, hyperpigmentation or hypopigmentation lesions. Mean erythema, pain, frequency of blistering and frequency of edema during 14 days of follow-up were not significantly different between the two groups (P>0.05).

During the 14-day follow-up period after therapy, topical betamethasone had no effect on the incidence of blisters and edema, as well as the average score of pain and erythema. As a result, this treatment modality cannot be used to relieve inflammation following cryotherapy in patients with warts.

Melanoma is the most aggressive and fatal type of skin cancer caused by the uncontrolled proliferation of melanocytes. The ineffectiveness of existing therapies has encouraged researchers to use herbal medicines. Amygdalin is a natural cyanogenic glycoside that is found in fruits and seeds of different plants and has antiproliferative, antioxidant, and immune-regulating activities. In this study, we aim to evaluate the effect of amygdalin against murine melanoma cancer cell line and normal human fibroblast cells.

The murine melanoma cancer cell line (B16F10) and human foreskin fibroblasts (HFF) cells were exposed to different concentrations of amygdalin and dacarbazine (a standard anticancer drug) for 24 and 48 hours. The half-maximal inhibitory concentration (IC50) of amygdalin was obtained using the MTT assay and analyzed in GraphPad Prism and Excel applications.

Amygdalin had a high cytotoxic effect on the melanoma cell line within 48 hours of exposure, which is comparable to the cytotoxicity of dacarbazine at the same time. Amygdalin had no cytotoxic effect on HFF cells, while dacarbazine caused a high toxicity on HFF cells.

Amygdalin, by inhibiting the proliferation of cancer cells in a dose-dependent manner, may prevent the adverse effects of chemical drugs on healthy cells and can be an appropriate treatment option for melanoma.

National studies on the prevalence of skin problems of the Iranian are very limited. The aim of this study was to determine the skin complaints of adult male population.

In this cross-sectional study, 1419 men over 35 years from 32 provinces participated by invitation. Demographic information, underlying disease history and presence of skin problems/diseases were collected by dermatologists. The participants were evaluated in terms of the presence of skin complaints (itching, burning, dry skin, redness, scaling, and skin color change); and any skin complaints with type, severity and location.

About one third 31.6% of the Iranian male middle-aged and elderly, had an underlying disease (n=449). High blood pressure, diabetes, and neurological disorders constituted 79.7% of the chronic diseases. In total, n=344 persons (24.2%) were rated as having skin complaint. Most people who had a skin complaint reported more than one skin complaint 75.6% (n=260). The most common skin complaints were related to itching 14.6% (n=207) and dry skin 5.6% (23.3%) in studied population, which were mostly mild 59.3% (n=204) and localize 58.4% (n=201). The use of corticosteroids was stated in 7.2%(n=103) and the most common types of usage was oral 62.1% (n=64). There was significant correlation between skin complaint and occupational exposure (P=0.01); lower education level (P=0.05); corticosteroid usage in general (P<0.001) and both oral (P=0.02) and topical (P<0.001) corticosteroid.

Skin complaint is common among middle-aged and elderly Iranian men. The most common skin complaint are mostly mild and localized itching and dry skin.

Skin injuries with various causes may lead to legal action. Complaints are referred to specialized authorities such as Razi Hospital, before specialized forensic medicine commission comment. The present study surveyed demography of patients' complaints and initial diagnosis at the time of referral over a period of 6 months. 

In this retrospective study, patients referred for initial visit, from Forensic Medicine Office in the September 2018-March 2019, were examined. The patients' complaints at the time of referral and the clinical diagnosis made at the initial examination were recorded. 

A total of 220 patients including 176 women (80%) and 44 men (20%) with a mean age of 34.8 years were included. 42 different complaints were documented, including traumatic hair loss with 91 cases (41.4%) - the most common - followed by complications of laser hair removal with 32 cases (14.6%) and filler injections with 16 cases (7.3%). Scarring from trauma, reaction to chemicals during work or accidental contact, rare injuries from various treatments, and even cases of pediculosis (contamination of the accommodation) or zoster (complaint about care in the treatment center), etc. were observed.

Traumatic hair loss (mainly due to fight) was the most common complaint. Knowing other cases may expand physicians' awareness regarding the wide range of complaints that can be raised and improve the process of some treatment measures.

Using a flipped classroom with proper design improves learning and competencies. The aim of this study was to investigate the effects of the virtual flipped classroom on teaching dermatology to medical internship students.

Methods and Materials:

 A quasi-experimental study with a pre-test post-test group design was conducted on 38 medical internship students of Mashhad University of Medical Sciences in the second semester of the academic year 1399-1400. The stages of the study were: pre-testing at the beginning of the course, presenting electronic content in the field of dermatology, participating in online flipped classrooms, and finally conducting a post-test. To achieve satisfaction, a questionnaire was provided to students and the mean score of the questions was compared using a one-sample t-test with a mean value of zero. The effect on learners' knowledge was investigated by comparing the mean scores of pre-test and post-test using paired t-test.

Thirty-eight interns, including 17 males and 21 females with an average age of 24/8 ± 0/57 years and an average grade of 88/0 ± 8/3 (out of 100 scores) were enrolled. The mean score of all satisfaction questionnaire items was significantly higher than zero. The increase in post-test score compared to pre-test was statistically significant (t = 2.82; P = 0.009). There was no significant relationship between gender, age, and grade point average with satisfaction and learning.

Interns have a positive attitude towards the virtual flipped classroom. Dermatology virtual flipped classroom can significantly improve the level of knowledge of them.

The COVID-19 pandemic is still present and we are directly or indirectly affected by it. The skin is one of the organs that has some manifestations not only during the course of the disease, but also long after recovery and also after vaccination. Hair is one of the parts that, like the skin, may show disorders during and after recovery of the infection and also after vaccination. In this issue, we aimed to provide an overview of the effects of COVID-19 and vaccination on hair. We also express the instrumental role of hair in the study of other diseases, including psychological problems.

Care of patients with skin diseases may lead to high financial costs and burden on health system for societies and family members. In this study, we decided to evaluate the costs of treatments of patients admitted in the dermatology ward of Afzalipour Hospital, Kerman.

This is a retrospective, cross-sectional study performed from 2011 to 2017 on patients admitted in the dermatologic ward of Afzalipour Hospital. Demographic features of patients, duration of admission, cost of treatment, number and type of prescribed drugs as well as the patients’ and insurance organizations’ shares of the cost were recorded.

In this study, 940 patients were evaluated for six years. The mean age of the patients was 38.05±22.35 years and most of them were female. The mean duration of admission was 8.42±2.54 days. The insurance companies’ and patients’ shares of the fees were 93.8% and 6.2%, respectively. The highest costs belonged to prescribed drugs (37.9%) and hoteling (30.3%). The most common prescribed drugs were antihistamines (33.1%), topical steroids (27.7%) and systemic steroids (24.5%). The mean number of prescribed drugs in each admission was 6.30±4.02 (range
0-20). Patients suffering from Erythema and urticaria had the total highest costs of admission (81,360,000 Iran Rials).

In this study, the most frequent skin diseases were infectious and papulosquamous diseases. The highest and lowest cost of admission belonged to prescribed drugs and consultations, respectively. Also, the highest cost of admission belonged to patients with erythema and urticaria.

It is clear that the correct knowledge of scales and the identification of fish without scales are specialized propositions that cannot be achieved without the necessary knowledge. The body of most fish is covered with scales. The scales are made of horny or bony material.

Scales from the dorsal fin are slowly separated from the body of the fish. Place in sodium hypochlorite solution to remove mucus or other undissolved material. The scales are then washed and dehydrated in ethanol series. Finally, it is covered with a thin layer of gold and examined by electron microscopy.

All cartilaginous fish have placoid or plate scales or serrated teeth on the outer surface of their body. Many eels, such as freshwater eels, have small, elliptical cycloid scales that attach to the skin. Catfish generally do not have clear and uniform scales and their bodies are often naked. Catfish do not have distinct scales and instead have leathery skin. Catfish evolved differently and have no scales.

The presence of scales in all cartilaginous fish (shark, shield and table fish) and some snake fish is clearly confirmed and proven, but in catfish the usual structure of scales is not confirmed and instead skate structures that have the same function as scales. And plays the role of scales or sequins is approved.