cardiac troponin

The purpose of this research was to explain the protective effect of quercetin on cardiac fatigue caused by exercise in skyrunning runners.

26 professional sky running athletes voluntarily and purposefully participated in this race. Random people were placed in 2 groups: quercetin (13 people) and placebo (13 people). The race was held in the central Alborz mountains, the total distance traveled was 21 km and 200 meters, the altitude of the starting point was 1650 meters above sea level, the maximum altitude was 3150 meters above sea level. Before and immediately and 1 hour after the end of the race, blood was taken from the subjects. In order to check the changes of the studied variables, the independent T-test was used at the significance level of alpha 0.05.

The amount of cardiac troponin T decreased significantly immediately and 1 hour after the end of the race in the quercetin group compared to the placebo group (P < 0.05). No significant difference was observed between the two groups of quercetin and placebo in the pre-test, immediately after the test and 1 hour after the test (P>0.05).

It seems that the increase of free fatty acids after the competition and long-term sports play an important role in reducing cardiac inotropic during the same period. Skyrunning competitions cause an increase in heart damage indices in professional athletes, despite this, quercetin supplementation reduces the increase in cardiac troponin T and can have a protective effect on the athlete's heart

 One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. 
Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. 

 In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05.

 The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591).

 he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.

Cardiac troponin I and T (cTnI and cTnC) are regulatory proteins that encounter in myocardial contraction and are specific sensitive markers of cardiac cell necrosis. The aim of this study was to determine the effect of continues and high-intensity training (HIIT) on cTnT and cTnI gene expression in the cardiac tissue of male Wistar rats. In this experimental study, 18 Wistar rats with body weight average 263±12 gr were studied for eight weeks in three groups: control, continuous endurance training (CET) (five sessions per week at 70% max speed) and HIIT (three sessions per week at intensity of 90 to 110% max speed) under standard conditions. Expression of cTnT and cTnI genes were assessed by Real time-PCR and the quantification of expression levels was analyzed by the 2-ΔΔct formula and one-way ANOVA statistical method with the significance level of p≤0.05. There were significant differences in the mean expression of cTnT between control group and both CET (p=0.001) and HIT (p=0.001) groups. The expression of cTnT was higher in HIIT than endurance training group (p=0.021). The results also showed that there was no significant difference in the mean of cTnI expression between different groups (p=0.523). According to the findings, it seems that eight weeks of HIIT and CET can decrease the expression of cTnT which could be a result of reduction of hemodynamic and physiological pressures on the heart. These changes may be accompanied by reduction of heart damage