جستجوی مقالات مرتبط با کلیدواژه « گاستریت مزمن » در نشریات گروه « پزشکی »

Identifying precancerous lesions for early detection of gastric cancer is greatly important in high risk areas for stomach cancer. In this study, we evaluated stomach biomarkers as a non-invasive method for recognition of gastric precancerous lesions. In a cross-sectional study, patients with chronic dyspeptic symptoms who were candidate for endoscopy were selected from Sari gastroenterology clinic. After endoscopic and pathological evaluations, patients were divided into three groups: those with normal endoscopic findings and pathology, patients with chronic active gastritis, and those with intestinal metaplasia. Their serum samples were evaluated for PG1, PG2, PG1/PG2 ratio, Gastrin-G17, and Helicobacter pylori serology. Data analysis was done in SPSS V21. A total of 63 patients were investigated of whom 19 were found with normal endoscopic results and pathology, 25 had chronic active gastritis, and there were 19 with intestinal metaplasia. Serum levels of PG1 and PG2 in patients with chronic active gastritis and intestinal metaplasia were higher than normal patients (p<0.05). These patients also had higher incidence of Helicobacter pylori infection compared with normal patients. (75% vs. 21%). Measurement of PG1, PG2, and anti-H pylori antibody in dyspeptic patients can be helpful in identifying gastric precancerous lesions.

Osteoporosis and bone fracture consequence to it is an important cause of disability particularly in the elderly women. Identifying the causes of osteoporosis and its treatment is important in fracture prevention. The present study was parformed to determine the relationship between helicobactor pylori infection (HP) and ostoporosis in the women. In this cross sectional study, forty-two women with clinical features of dyspepsia due to HP– induced chronic gastritis confirmed by gastroscopy and biopsy were compared with 52 healthy control women without dyspepsia. Bone mineral density (BMD) was assessed by dual energy x-ray absorptiometry (DXA). Femoral neck BMD gr/cm2 and spine BMD gr/m2 were compared between whole number of two groups as well as between patients and controls according to age. The mean age of patients and controls were 51.6± 9.2 and 51.7± 6.5 years, respectively. There were no significant differences in mean spine and femoral neck BMD between the whole numbers of patients and controls. But in groups aged <50 years spine BMD in patients was nonsignificantly lower than controls and femoral neck BMD was higher than controls. There were not significant differences in mean spine and femoral neck BMD between patients and controls aged >50 and <50 years. Comparison of individuals aged >/=50 years with those aged < 50 years demonstrated a significant difference only in patients for spine BMD (p=0.017) but not in the controls. These findings indicate that HP-induced inflammation has no adverse effect over femoral neck BMD but has negative effect on spine BMD in women aged >/=50 years. Further studies with larger samples are needed to confirm these findings.

Chronic gastritis is one of the most common gastrointestinal disorders and detection of its etiology especially Helicobacter pylori and risk factors of malignancy (atrophy and intestinal metaplasia) is, to a great extent, based on histological assessment. Therefore, a system which could sustain good reproducibility in reporting observations is very important. Today, the most frequently used system for assessment and grading of chronic gastritis is the Updated Sydney System. The aim of this study was to find out inter-observer agreement on each criterion of this system (i.e reproducibility rate). In this descriptive analytical study, 44 endoscopic gastric biopsy samples (with hematoxylin, eosin, and geimsa stains) were reviewed by two pathologists in turn. Each pathologist graded any of Sydney System criteria including chronic inflammation and H.P density level from 0-3 (absent, mild, moderate and severe) glandular atrophy and intestinal metaplasia from 0-1 (absence and presence). In addition, neutrophilic infiltration (activity of disease) was also graded from 0-3. Finally results of the observation were analaysed by means of McNemar statistical test and K coefficient The most/best inter-observer agreement was found on intestinal metaplasia (K =0.84) representing. Good interobserver agreement was observed on chronic inflammation (K =0.67), H.P density (K=0.62) and neutrophilic infiltration (K=0. 68). For glandular atrophy, agreement was the least (K=0.32) Updated Sydney system is a useful system for the assessment and grading of chronic gastritis. In most cases there was good agreement between the observers. Reproducibility is evaluative differences in grading a specific feature and lack of standardized diagnostic criteria to charactrize its presence and degree.

Gastric cancer is the second most common cause of cancer related death in the world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with non-ulcer dyspepsia.Methods and Materials: During an eleven-month course (October 2001- September 2002) we studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by ELISA method.

Each group comprised of 21 male (52.5%) and 19 female (47.5%). Mean age was 53.18 and 56.58 years in control and case group, respectively. Anti-H. Pylori IgG was positive in 100% of patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a significant correlation between gastric cancer and Antibody test. (P= 0.000). Patients with gastric carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer.

Like other epidemiologic studies this study revealed that H. pylori infection is associated with an increased risk of gastric carcinoma and is considered as a cofactor in the pathogenesis of this malignant condition.