Blood pressure

Aging is a pervasive biological process that leads to a gradual and irreversible decline in physical function across all organ systems. The prevalence and severity of hypertension in women increase significantly with age.

This study investigated the effect of combined exercise (fitness and pilates) on metalloproteinase-1 levels and blood pressure indices in elderly women.

In this study, a purposive sample of 30 older women in Ahvaz was selected from the available community and randomly divided into an exercise group (pilates and fitness) and a control group (daily activity). The experimental group performed the exercise program for eight weeks, three sessions per week. Serum levels of metalloproteinase-1 and hemodynamic parameters were measured 48 hours before and after the intervention by ELISA using a human kit. Paired t-test and analysis of covariance were used to examine changes within and between groups. The significance level was set at P ≥ 0.05.

After eight weeks of exercise, hemodynamic values (including systolic, diastolic, mean blood pressure, and heart rate) and serum metalloproteinase-1 levels were significantly reduced (P < 0.05).

The selected exercise (pilates and fitness) changed hemodynamic indicators (blood pressure and heart rate) and decreased serum metalloproteinase-1 levels in elderly women. This exercise can return blood pressure to normal levels and help with complications.

The prevalence rate of hypertension is on the rise at an alarming rate. Studies conducted on the influence of flaxseed on blood pressure (BP) have come up with conflicting conclusions. The current investigation’s major purpose is to conduct a literature review and a meta-analysis focusing on the effect of flaxseed supplementation on BP in people with cardiovascular disease (CVD) risk factors. PubMed, Scopus, Web of Science, and Cochrane Central Library databases were searched from the inception date to April 2024 to find the randomized controlled trials (RCTs). A random-effects model combined the weighted mean difference (WMD). Standard methodologies were applied to evaluate publication bias, heterogeneity, and sensitivity analysis. Eighteen RCTs were included in the present systematic review and meta-analysis. Pooled analysis suggested that flaxseed supplementation can reduce systolic BP (SBP) (WMD: -4.75 mmHg, 95% CI: -7.05 to -2.44, P≤0.001; I2=93.6%) and diastolic BP (DBP) (WMD: -3.09 mmHg, 95% CI: -4.37 to -1.81, P≤0.001; I2=91.2%). In conclusion, the current meta-analysis has demonstrated that flaxseed supplementation can markedly lower BP in individuals exhibiting CVD risk factors. Given the significant heterogeneity, it is crucial to interpret the current results with careful consideration. In addition, further high-quality RCTs are required to better assess the causal relationships.

Essential hypertension, a common multifactorial condition, is a significant public health concern. In India, the prevalence of hypertension is high, with estimates indicating a rising trend. Shirodhara, an Ayurvedic therapy, has exhibited the potential for stress reduction and relaxation. Thus, the review investigates the effect of Shirodhara on systolic and diastolic blood pressure and its impact on clinical symptoms like palpitation, insomnia, giddiness, fatigue, and headache in essential hypertensive patients. We searched PubMed, Embase, Scopus, Google Scholar, and Shodhganga, Web of Science search for this systematic review and meta‑analysis from inception to June 2023. Evidence from RCTs was synthesized as a standardized mean difference (SMDs) for systolic and diastolic blood pressure, comparing participants who received Shirodhara intervention along with Ayurveda medication and those who received only Ayurveda medication. The Revised Cochrane Risk of Bias tool for randomized control trials (RoB‑2) was used for the quality assessment of randomized control trials. Analysis was done using Medcalc software. The comparison table is provided for the percentage of relief in clinical symptoms in both groups. Out of four RCTs, only three were included for quantitative analysis, which mentioned the mean and standard deviation of systolic and diastolic blood pressure. Meta‑analyses revealed the effects of Shirodhara on systolic blood pressure (n = 100), the mean difference (MD) was − 1.257 mmHg, (2.660–0.145), I 2 = 89.3%, and diastolic blood pressure (n = 100) MD was − 0.40 mmHg, (−0.79–0.01) I 2 = 0. The percentage of relief in clinical symptoms was notably higher in the Shirodhara and Ayurveda groups than in the Ayurvedic drug group. Shirodhara lowered diastolic blood pressure significantly, but it has low clinical value. Shirodhara’s effect on systolic blood pressure remained unclear. Relief in clinical symptom score was notable. Larger, well‑designed research is needed to prove Shirodhara’s effectiveness in hypertension management and optimize therapy methods.  

 Continuous Renal Replacement Therapy (CRRT) is commonly used in patients with hemodynamic instability but is associated with potential complications. Understanding these complications can improve CRRT efficiency and patient outcomes. 

This cross-sectional study investigated CRRT complications in patients > 18 years old who underwent CRRT at a tertiary medical center from 2017 to 2022. Data were collected from patient records and the hospital’s laboratory system. 

A total of 178 patients underwent CRRT for fluid overload (38%) and non-septic acute kidney injury (AKI) (35%). The most common CRRT modalities were hemofiltration (54%) and hemodiafiltration (31%). Among patients, 76% experienced a reduction in platelet count (mean decrease of 40% ± 24). Hemoglobin declined by ≥ 1 g/dL in 58% of patients. Phosphorus decreased in 64.6% of patients (mean reduction of 33%) and potassium decreased in 50% (mean reduction of 18%), but these reductions were not statistically significant (P-values: 0.73 and 0.88). Vasopressors were stopped in 27% of patients, and the dose was reduced in 50.4%. No significant hypothermia, allergic reactions, pneumothorax, hemothorax, or air embolism were reported. The survival rate at hospital discharge was 64% (123 out of 178). 

CRRT is a safe and efficient treatment for AKI, with notable reductions in platelet count and vasopressor dependency. However, reductions in phosphorus and potassium were not significant, indicating manageable complications.

Patients with coronary artery disease (CAD) can improve quality of life by undergoing coronary artery bypass graft (CABG), but they may face various complications. Early mobilization can help prevent these complications. This study aimed to evaluate the effects of two early mobilization protocols on pain and hemodynamic outcomes in patients who had CABG surgery.

This was a randomized, blinded clinical trial with a three-arm parallel design, conducted on 105 patients who underwent CABG at Shahid Madani hospital in Tabriz. The patients were randomly assigned to three groups: control, first intervention, and second intervention. The control group received standard care, while two intervention groups received early mobilization based on passive and active range of motion (ROM) activities and early mobilization based on deep breathing exercises respectively. Data were collected using a questionnaire that measured pain intensity using a facial pain scale and hemodynamic indicators using a monitor device. Data analysis was performed using SPSS version 24 software and descriptive and inferential statistics methods.

According to the study, the second intervention group is more effective than the first intervention group. The results indicated that in both morning and evening shifts, the mean of systolic blood pressure (SBP) increased significantly in three groups. Also, the mean of diastolic blood pressure (DBP) increased significantly in both shifts in intervention group 1 and control. The mean of DBP decreased (MD=-26.0, 95% CI: -5.6 to -1.2; P=0.003) significantly among intervention group 2 compared to control group in the evening. The results also indicated that the mean of heart rate (HR) raised significantly in both shifts in all three groups. In the morning, there was a significant difference between intervention group 2 and 1 compared to control. The mean of arterial oxygen saturation was a significant difference between intervention group 2 and intervention group 1 and control group in the both shifts. The mean of pain decreased significantly in the morning in two intervention groups. Similarly, in the evening, the mean of pain decreased significantly in intervention group 1, and intervention group 2. Both in the morning and evening, there was a significant difference between intervention group 2 and intervention group 1 (P<0.001).

This study provides valuable insights into the effects of early mobilization interventions on patients after CABG, but more research is needed to determine the optimal timing and intensity of mobilization protocols for patients after CABG and to explore the long-term effects and cost-effectiveness of these interventions.

Multisystem Inflammatory Syndrome in Children (MIS-C) is a rare but severe condition that can develop in children who have had COVID-19. It can lead to cardiovascular complications, potentially caused by endothelial dysfunction and arterial stiffness.

This study aimed to investigate the cardiovascular health of children with MIS-C compared to healthy controls. Fifty-nine children with MIS-C and fifty-nine healthy individuals were included in this cohort study. Non-invasive techniques were employed to measure the brachial artery’s flow-mediated dilation (FMD), aortic distensibility (AD), and aortic strain (AS).

The MIS-C group demonstrated significantly higher systolic blood pressure (P = 0.012), with a mean of 100.2 (10.1) mmHg compared to 95.3 (9.6) mmHg in the healthy group. The relative risk (RR) for elevated pulse pressure in the MIS-C group was borderline higher than in the healthy group (RR 95% CI: 1.06 [1.01–1.14]; P = 0.046). However, FMD, AS, and AD values were lower in the MIS-C group, with means of 13.6 (8.9), 10.4 (4.1), and 15.5 (2.7), respectively, although no significant differences were observed (P > 0.05).

Children with MIS-C exhibited higher pulse pressure, indicating potential arterial stiffness. They also showed lower FMD, suggesting endothelial dysfunction. FMD appears to be a more reliable indicator of endothelial dysfunction in MIS-C patients compared to aortic strain. These findings underscore the importance of early assessment and monitoring of cardiovascular complications in MIS-C patients. Endothelial dysfunction and arterial stiffness are well-established risk factors for future cardiovascular events.

Farmers need the right strategy to control blood pressure through Community-Based Occupational Health Promotion (COHP) Program interventions for reducing blood pressure. This study aims to analyse the effectiveness of COHP interventions to maintain blood pressure of farmers.

This study used a randomized control trial design. COHP interventions were performed in intervention (68 participants) and control (67 participants). The study was conducted for 24 weeks with intervention at 0-4 weeks and continued with follow-up at 5-24 weeks for participants in four Public Health Centres (PHC) areas in Indonesia. Data were collected using a stethoscope and aneroid sphygmomanometer to measure blood pressure. Data were analysed using Fisher's exact test, to analyse the differences in systolic (SBP) and diastolic (DBP) blood pressure in both groups.

In after 24 weeks of CHOP, there were significant differences SBP between intervention and control groups (126.81 ± 14.52 Vs. 146.65 ± 16.38; p< 0.001). Meanwhile, there were significant differences DBP between intervention and control groups (83.03 ± 8.31 Vs. 86.91 ± 7.73; p= 0.003). Furthermore, the COHP was effective for reducing SBP and DBP (p< 0.001) among farmers.

This study indicates that COHP can be effective for reducing SBP and DBP among farmers in agricultural areas.

There is a belief that opium consumption has a protective effect on hypertension and diabetes, which are important risk factors for cardiovascular disease.

This study aimed to compare blood pressure and blood sugar measurements between opium users and non-users.

This cross-sectional study is based on the Fasa Adults Cohort Study (FACS). Participants from FACS who had no history of diabetes or hypertension with medication were included in this study. Systolic and diastolic blood pressure as well as fasting blood sugar (FBS) were compared between participants who use opium (regularly or ever) and those who do not, across different sociodemographic characteristics such as sex, marital status, employment, smoking, and other variables such as age, BMI, and physical activity. To control for the effect of confounders, a linear regression model was used in SPSS version 22.

A total of 7,428 adults participated in this study. The mean age of participants was 46.5 years. Of the participants, 27.05% were opium users. The mean diastolic blood pressure was 73.18 mmHg in non-opium users, while it was 70.95 mmHg in opium users (P = 0.000). The mean systolic blood pressure was 105.20 mmHg in opium users, compared to 107.78 mmHg in non-users (P = 0.000). The mean fasting blood sugar was 86.75 mg/dL in non-opium users and 85.88 mg/dL in opium users (P = 0.019). Lower blood pressure was observed in opium users despite higher fasting blood sugar levels.

After controlling for confounders such as age, sex, smoking, BMI, physical activity, and calorie intake, both systolic and diastolic blood pressure were lower in opium users, while fasting blood sugar was higher. Given the numerous side effects of opium, it should not be used arbitrarily. However, these findings could be useful when making clinical decisions for diabetic or hypertensive individuals who are opium users.

To examine the association between metabolic syndrome, and rotating shift work, this study examined the prevalence of metabolic syndrome, and its components among rotating shift workers and day workers in Pars Special Economic Energy (Bandar-e-Asalouyeh), southwest Iran.

We conducted a cross-sectional study using the data of 1249 workers in the petrochemical industry. Statistical significance was assessed using Chi-square and independent t-tests. A multivariate and univariate analysis was used to assess the metabolic syndrome impact factors.

Shift workers were younger and had less education than day workers. The prevalence of metabolic syndrome was 11.6% among study participants, 13.4% among day workers, and 8.9% among shift workers. In the multivariate analysis, shift workers had an odds ratio of 0.9 for developing metabolic syndrome (95% CI= 0.58–1.37, p=0.619). Day workers were likelier to have low high density lipoprotein than shift workers (OR: 0.57, CI: 0.44-0.74, p=0.000). Physical activity at shift time (OR =0.84, CI =0.72-0.98, p=0.031), and increasing age (OR 1.05; 95% CI; 1.03-1.07; p<0.000) show an association with metabolic syndrome.

In the Iranian workers, metabolic syndrome was less prevalent than general population. A statistical difference in the metabolic syndrome prevalence was not found between shift workers and daytime workers. A rotating shift with night and day work schedules is probably not associated with metabolic syndrome. The adverse effects of working night shifts can be alleviated by physical activity.

Introduction. This study aimed to analyze the correlation between blood pressure variability (BPV), crystalloid osmotic pressure, and cardiovascular events (CEs) in patients undergoing maintenance hemodialysis (MHD). Methods. This retrospective analysis was conducted on 71 patients with end-stage kidney disease who underwent hemodialysis at Beilun District People’s Hospital from September 2021 to September 2022. The patients were divided into two groups based on the occurrence of CEs: a cardiovascular event group and a non-cardiovascular event group. Results. The 71 patients were divided into two groups based on the occurrence of CEs: the CEs group (25 patients who experienced CEs) and the non-CEs group (46 patients who did not experience CEs). The CEs group had significantly higher levels of crystalloid osmotic pressure, standard deviation of systolic BP (SBP-SD), coefficient of variation of SBP (SBP-CV), SD of diastolic BP (DBP-SD), and DBP-CV (P < .05). Multivariate logistic regression analysis identified crystalloid osmotic pressure, SBP-CV, and DBP-CV as independent risk factors for CEs. The ROC curve analysis indicated that the combined predictive value of crystalloid osmotic pressure, SBP-CV, and DBP-CV was significant, with an area under the curve (AUC) of 0.963. Conclusion. Elevated crystalloid osmotic pressure, SBP-CV, and DBP-CV are critical risk factors with strong predictive value for predicting CEs in MHD patients

Hypertension is the most significant modifiable risk factor for cardiovascular disease (CVD) and is associated with substantial negative effects on both individual and societal levels. Renal denervation (RDN) has been established as a safe and effective medical intervention for treating resistant hypertension, with approval from the Food and Drug Administration and endorsement by guidelines such as those of the European Society of Cardiology (2023) and the American Heart Association. However, with the advent of various types of RDN methods, including radiofrequency-, ultrasound-, and alcohol-based techniques, debates have intensified regarding their comparative efficacy and safety. Additionally, researchers have expanded their focus to consider outcomes beyond hypertension management. Most studies have demonstrated that this non-pharmacologic treatment significantly improves systolic and diastolic 24-hour ambulatory and office blood pressure in both the short- and long-term. Despite these findings, the social and psychological impacts of RDN on a broader scale have been less frequently discussed. Given the high burden of hypertension and its complications, such as cardiovascular and cerebrovascular events, this intervention could substantially enhance the quality of life and mental health of affected populations. Non-adherence to antihypertensive medications remains a critical challenge, driven by factors such as side effects, pregnancy, financial constraints, psychiatric disorders, and polypharmacy with its associated consequences. Renal denervation, by improving blood pressure control, offers the potential to enhance quality of life and reduce the incidence of severe physical and mental health conditions. This study provides a comprehensive perspective on this advanced treatment, emphasizing its impact on individual and societal well-being, physical health, and mental health.

This systematic review and meta-analysis aimed to evaluate the prevalence and clinical implications of metabolic syndrome in individuals with diabetes mellitus. 

A comprehensive search was conducted across multiple databases using key terms related to metabolic syndrome and diabetes. Access to subscription-based journals was facilitated through the HINARI program. Study quality was assessed using the adapted Newcastle–Ottawa scale, with a minimum inclusion score of ≥5/10. Statistical analysis included a meta-analysis using the DerSimonian and Laird random-effects model to determine the pooled prevalence, with heterogeneity assessed using Cochran’s Q and I² statistics. Publication bias was evaluated via funnel plot symmetry. Analyses were conducted using Stata/MP 17.0.

The meta-analysis revealed a pooled effect size of 1.98 (95% CI: 1.85, 2.10), with significant heterogeneity (I² = 92.35%). Prevalence ranged from 19.88% to 88.13%, underscoring a substantial burden. Variations in HbA1c, HDL cholesterol, blood pressure, and BMI highlighted the heterogeneity in metabolic syndrome characteristics. Advanced statistical approaches enriched the understanding of metabolic profiles and their interplay with glycemic control and lipid metabolism.

This study underscores the critical interplay between glycemic control and lipid profiles in metabolic syndrome. The findings emphasize the need for tailored, region-specific interventions to address its substantial burden and implications for clinical practice and policy.

The use of herbal teas can affect some physiological parameters of the body. Valerian has been used as a valuable medicinal plant. There are reports about sedative and sleep-inducing effects of Valeriana officinalis L. (VOT) on the nervous system. But in relation to its possible effect on the autonomic nervous system, the available information is limited. This study aimed to determine the effect of VOT on sympathovagal tone based on heart rate variability indices.

In this semi-experimental study, 12 healthy volunteers were enrolled. At first, the participants received 50 ml of water as the control group, and then after the clearance time, they received VOT with a dilution of 50% with the same temperature and volume and were considered the intervention group. Assessment of sympathovagal tone was performed in terms of heart rate variability indices. There were 5 recording steps: baseline, after drinking water, and 5, 20, and 30 minutes after drinking VOT.

The mean±SD of the average heart rate per minute at the five recording steps after VOT was 65.4±15.5, 63.5 ±14.6, 62.7±15.6, 61.8±16.09, and 60.9 15.2, respectively (p <0.05). The average arterial systolic pressure at the five recording steps after VOT was 119.4±7.4, 117.9± 9, 114.3±7.9, 113.8±8.6, and 114±6.5 mmHg, respectively.

A single cup of VOT significantly decreased the heart rate. This effect may be associated with a decrease in sympathetic activity and an increase in parasympathetic activity.

The relationship between body mass index (BMI) and blood pressure in the Vietnamese population has not been clearly defined. This study aims to examine the clinical characteristics and BMI of hypertensive patients and investigate the relationship between BMI and blood pressure.

This study employs a cross-sectional descriptive design and random sampling. Participants’ blood pressure was measured 3 times using an automatic sphygmomanometer.

A total of 5910 individuals participated in the study, with 2138 being diagnosed with hypertension. Among the participants, 20.8% were overweight, 20.8% were obese, and 9.9% were underweight. Linear regression analysis demonstrated a positive correlation between BMI and systolic blood pressure in both sexes (men: r = 0.339, P < 0.05; women: r = 0.324, P < 0.05; overall: r = 0.345, P < 0.05). After adjustments for age and gender, a 1-unit increase in BMI corresponded to a 1.414 mm Hg increase in systolic blood pressure. Obesity and overweight were associated with an increased risk of hypertension compared with normal weight (OR, 1.91; 95% CI, 1.67 to 2.18; P < 0.05 and OR, 1.81; 95% CI, 1.58 to 2.07; P < 0.05, respectively). Conversely, being underweight was associated with a reduced risk of hypertension (OR, 0.34; 95% CI, 0.27 to 0.43; P < 0.05).

The study found a positive correlation between BMI and blood pressure. It is advisable to manage weight even in individuals without hypertension and utilize BMI as a tool for detecting hypertension within the community. 

 Hypertension (HTN) has become a serious health problem in developing countries. The family has an important role in maintaining blood pressure (BP) at home, and sodium diet compliance in people with HTN needs to be developed. Therefore, this research aimed to evaluate the effectiveness of a family self-management program (FSMP) in HTN management and compliance with sodium consumption in rural areas of Indonesia.

Study Design:

 A parallel-group, single-blind randomized controlled trial.

 One hundred twenty-six eligible participants were randomly allocated to an intervention (n=63) and a control group (n=63). Participants in the intervention group received a 24-week (6-month) FSMP intervention. The primary outcome measures included the systolic and diastolic BP, the Score Sodium Questionnaire (SSQ), and the Morisky Medication Adherence Scale 8 (MMAS-8). The Knowledge of Health Care for HTN questionnaire and the Efficacy and Behavior Toward Health Care for Patients with HTN questionnaire were used to assess the secondary outcome.

 The final results were analyzed from 121 participants (n=61 intervention and n=60 control group). The repeated analysis of variance (ANOVA) test results demonstrated significant effects on the management of HTN and adherence to sodium consumption as indicated by systolic (P=0.004) and diastolic BP (P=0.006), SSQ (P<0.001), MMAS 8 (P<0.001), caregivers’ knowledge (P<0.001), caregivers’ self-efficacy (P<0.001), and caregivers’ behaviors (P=0.005).

 The FMSP emerges as a promising strategy for managing BP and adherence to sodium consumption in people with HTN through the support of family caregivers and selfmanagement activities.