جستجوی مقالات مرتبط با کلیدواژه "Malondialdehyde" در نشریات گروه "پزشکی"

The aim of this study was to investigate the effect of 6 weeks of high intensity interval training (HIIT) on the serum levels of oxidative stress parameters(malondialdehyde, superoxide dismutase and catalase) of athletics athletes in Yasouj city

In this quasi-experimental study, the statistical population was male track and field athletes in Yasuj, excluding female endurance athletes; among them, 30 female sprinters, throwers, and jumpers in the age range of 22-32 years were purposefully selected as a statistical sample and randomly divided into 2 groups of 15 (HIIT training and control).HIIT training protocol was performed at an intensity of 90% of maximum heart rate for 6 weeks (3 sessions per week). Blood samples were taken from the subjects before and after training and kits were used to measure malondialdehyde, superoxide dismutase, and catalase. Paired t-test was used to determine intra-group changes, and covariance test was used to compare between groups at a significance level of p<0.05 (p<0.05). The obtained data were analyzed with SPSS-25.

The findings showed that serum levels of malondialdehyde, superoxide dismutase, and catalase in the training group after six weeks of HIIT training were significantly different from the pre-test (p=0.00). Also, serum levels of these variables were significantly different between the training group and the control group at the post-test (p=0.01).

The results of this study showed that in order to reduce oxidative stress and improve the antioxidant capacity of runners, HIIT exercises can be used in runners' training program.

Age-related metabolic changes and oxidative damage in the brain, particularly in the hippocampus, can contribute to cognitive decline and the onset of neurological disorders. This study aimed to investigate the effects of aerobic interval training and ginger extract on catalase and superoxide dismutase (SOD) activity, as well as malondialdehyde (MDA) levels, in the hippocampus of aged rats.

This semi-experimental study involved 20 Wistar rats with an average weight of 500 grams, randomly divided into four groups (n=5): control, ginger, training, and ginger, training+ginger group. The aerobic interval training protocol lasted for eight weeks, with three sessions per week. Ginger extract was administered at a dose of 100 mg/kg, dissolved in water and provided as the drinking water. One-way ANOVA and Tukey's post-hoc test were employed to analyze the data.

Tukey's post-hoc test revealed that the mean MDA levels in both the training group and the training+ginger group were significantly lower than those in the control group (p=0.005 and p=0.013, respectively). Additionally, the mean levels of catalase and SOD in the training+ginger group were significantly higher compared to the control group (p=0.016 and p=0.034, respectively). No significant differences were observed between the means of the other groups and the control group.

The findings suggest that both aerobic exercise and its combination with ginger extract lead to a reduction in MDA levels. Although exercise and ginger consumption alone did not significantly affect MDA, SOD, or catalase levels, their combined effect resulted in an increase in antioxidant enzyme activity.

Oxidative stress (OS) is one of the main factors of neuronal damage during cerebral ischemia. OS leads to the formation of reactive oxygen species (ROS) and triggers several destructive mechanisms, including mitochondrial dysfunction, elevated calcium levels, reperfusion injury, and inflammation. This study aimed to investigate the effects of eight weeks of endurance training on the expression of malondialdehyde (MDA) and superoxide dismutase (SOD) in the hippocampus of rats following ischemic stroke.

In this experimental study, 21 adult male Wistar rats were randomly assigned to three groups: control, stroke, and stroke + training. Brain ischemic stroke was induced by occluding both common carotid arteries (CCA) for 45 minutes. The training group underwent treadmill running at speeds ranging from 18 to 30 meters per minute, with sessions lasting 20 to 50 minutes, five days per week for eight weeks. Forty-eight hours after the final training session, the rats were sacrificed, and the gene expression of SOD and protein expression of MDA in the hippocampus were analyzed.

Ischemic stroke resulted in a significant increase in MDA protein expression and a decrease in SOD gene expression in the hippocampus of rats compared to the control group. However, endurance training significantly reduced MDA protein expression and enhanced SOD gene expression in the hippocampus of rats following ischemic stroke.

Endurance training increased SOD gene expression and decreased MDA protein expression, leading to reduced OS and enhanced antioxidant defense in rats following brain ischemic stroke. These findings highlight the potential of physical exercise as a therapeutic strategy for reducing oxidative damage after ischemic events.

 Obesity and overweight is a growing health concern. One of the important factors in obesity-related diseases is oxidative stress and the disruption of the body’s antioxidant system. The aim of this study was to investigate the effect of eight weeks of whole-body high-intensity interval training (WB-HIIT) with the consumption of mango leaf extract on the serum levels of oxidative and antioxidant stress in overweight and obese men.

 This semi-experimental study was conducted on 40 untrained men aged 32.4±4.1 years with a body mass index of 30.13±2.6 kg/m2. The participants were studied knowingly, and their written informed consent was obtained. They were placed randomly in four groups: WB-HIIT+placebo, mango leaf extract, WB-HIIT+mango leaf extract, and control. The mango leaf extract and placebo groups consumed one 500 mg capsule of mango leaf extract and placebo daily for eight weeks, respectively. Blood samples were taken before and after the eight-week intervention. In the analysis of serum malondialdehyde (MDA) and total antioxidant capacity (TAC), t-test and one-way analysis of variance were used (P≥0.05).

 The results showed that there were no significant differences between the four groups before the intervention. However, after eight weeks of WB-HIIT with the consumption of mango leaf extract, the values of serum TAC increased significantly (1.304±0.17) compared to the control group (0.405±0.16) (P=0.001). Despite this, even though there was a decrease (P=0.059) in the serum MDA values of the subjects in the studied groups, the difference was not significant.

 WB-HIIT with mango leaf extract can improve some antioxidant factors in overweight and obese people and prevent increased oxidative stress.

In the last decade, vitamin D has attracted more attention as a non-enzymatic antioxidant compound. The aim of this study was to survey of changes in BDNF and malondialdehyde (MDA) levels after a period of high intensity interval resistance training (HIIRT) and vitamin D intake in inactive overweight women women.

The subjects were first selected by the available sampling method, then they were randomly divided into four groups: control, interval exercise, vitamin D, and combined. HIIRT was performed in three sets at intensity with 80% one maximum repetition and 2.5 minutes rest between sets. Vitamin D and combined groups consumed vitamin D (50000 units) once a week. BDNF and MDA levels were measured before and after the interventions.

The findings showed that the MDA levels in the interval exercise, vitamin D and combined groups decreased after 8 weeks and BDNF levels increased significantly. But the combined intervention had a stronger effect on the change of MDA and BDNF levels compared to the other two interventions (p<0.05). In addition, no significant difference was observed between the changes in the levels of interval exercise and vitamin D (P<0.05).

It seems that HIIRT and vitamin D consumption can exert their protective effects in overweight people with abnormal levels of vitamin D, by reducing MDA levels and up-regulation of BDNF protein. But these effects were further developed with combined intervention.

It is well-established that high-intensity interval exercise (HIIE) contributes to an increase in reactive oxygen species, accompanied by enhanced antioxidant activity. However, the effects of HIIE on liver tissue remain poorly understood. This study aimed to evaluate the effects of HIIE on liver redox status and liver enzymes in male Wistar rats.

This study employed a true experimental research design, specifically a post-test-only control group design. Twenty-five male Wistar rats were randomly divided into three groups: control (Control, n = 8), one-hour HIIE exercise group (HIIE-1h, n = 8), which were sacrificed one hour after training, and twenty-four-hour HIIE exercise group (HIIE-24h, n = 9), which were sacrificed 24 hours after training. The two HIIE groups underwent a single treadmill run consisting of 10 bouts of high-intensity exercise (85–100% of VO2max) lasting 1 minute each, at 28 m/min, with a 10° incline, interspersed with 2 minutes of active recovery at 10 m/min, with no incline. Superoxide dismutase (SOD), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and malondialdehyde (MDA) enzymes were measured in liver tissue. Data analysis was performed using SPSS statistical software (version 19) at a 95% confidence level. One-way analysis of variance (ANOVA) was used to analyze the research's levels of dependent variables.

The study results showed that the SOD level in liver tissue was significantly lower in the HIIE-1h (P = 0.004) and HIIE-24h (P = 0.008) groups compared to the control group (P < 0.05). Additionally, the MDA level in liver tissue was significantly higher in the HIIE-1h (P = 0.002) and HIIE-24h (P = 0.005) groups compared to the control group. The levels of ALT in the HIIE-1h (P = 0.003) and HIIE-24h (P = 0.02) groups and AST in the HIIE-24h (P = 0.004) group were significantly higher compared to the control group.

HIIE leads to oxidative stress and an increase in liver damage marker enzymes. These changes persist for at least 24 hours after exercise, highlighting the importance of focusing on recovery time after HIIE. However, further studies are needed in this field.

Cyclophosphamide (CP) is an immunosuppressive medication which is primarily used to manage and treatt of neoplasms, including breast cancer, lymphoma and Leukemia. CP as well possesses many side effects, including hepatotoxicity which leads to mitochondrial oxidative stress, cell death and hepatic necrosis. Empagliflozin (EMPA) is a Sodium-glucose cotransporter-2 inhibitor used to treat diabetes and has antioxidant activity. The present study was designed to investigate the effect of Empagliflozin on hepatotoxicity induced by cyclophosphamide in male rats.

The present experimental study was conducted at the School of Medicine, Yasuj University of Medical Sciences in 2023. Twenty-four male Wistar rats were divided into four groups: control group, CP group, EMPA+CP group and CP+EMPA group. All groups were treated for 11 days. Moreover, blood samples were obtained and the liver was removed. Plasma levels of ALT, AST and ALP were measured. Homogenized liver tissue was used to measure malondialdehyde (MDA), Nitric Oxide (NO). Liver histology was also performed. The results were analyzed by one- way ANOVA and Tukey's Post Hoc test.

The results indicated that cyclophosphamide triggered a significant increase in the plasma level of AST, ALT enzymes and the level of NO and MDA metabolites in the liver tissue (p<0.001) and increased inflammation, edema, congestion and tissue necrosis compared to the control group. The administration of Empagliflozin led to a decrease in plasma levels of AST and ALT enzymes and tissue levels of NO and MDA and decreased tissue changes compared to the cyclophosphamide group. Furthermore, Empagliflozin reduced histological changes both as prevention and as treatment.

According to the results of the present study, Empagliflozin can reduce the hepatotoxicity of cyclophosphamide probably with reduction of oxidative stress.

A high-fat diet and increased calorie intake increase the prevalence of obesity،,which itself causes many diseases. The studies carried out in the field of investigating the mechanisms related to obesity and its related diseases have introduced the increase of fat mass and as a result the disruption of cytokines as one of the most important influencing factors. Therefore, the aim of the current research was the effect of eight weeks of intense interval training on serum lipid peroxidation indices and adiponectin gene expression in obese mice.

The current research was experimental with a control group. 24 male rats were randomly divided into three control groups, self-obesity group and self-obesity group with high intensity interval training (HIIT). The normal distribution of the data was evaluated using the Shapiro-Wilk test. Then، in order to compare data between groups، one-way analysis of variance was used, and if it became significant، the data were compared using Tukey's post hoc test at a significance level of P < 0.05.

The findings of this research showed that in the exercise group, there was a significant increase in the state of superoxide dismutase (SOD) compared to the self-obesity group. However,, there was no significant change in the level of malondialdehyde (MDA) and the level of adiponectin gene expression in the liver of self-obesity group and interval training group.

Obesity causes an imbalance in the oxidative status and a disturbance in the production and secretion of adiponectin in the liver tissue of obese mice، and intense intermittent exercise improves the oxidative status, but it does not have a significant effect on the expression of the adiponectin gene

Diabetes, along with morphine, can lead to metabolic damage in testicular tissue through oxidative stress. This study aimed at investigating the effects of eight weeks of moderate-intensity endurance training on some oxidant and antioxidant indices in the testicular tissue of diabetic rats with acute morphine withdrawal syndrome.

In this experimental study, 32 male Wistar rats were randomly divided into four groups of eight: 1) diabetes control, 2) morphine + diabetes, 3) diabetes + moderate-intensity endurance training, and 4) morphine + diabetes + moderate-intensity endurance training. Diabetes was induced and morphine was administered to create the acute morphine withdrawal syndrome. The training groups underwent an eight-week endurance training protocol. Oxidant and antioxidant indices, including MDA, TAC, GPX, and SOD, were measured in the testicular tissue at the end of the study.

The concentration of the oxidant index MDA significantly increased in the diabetes group compared to the other groups (P=0.001). However, moderate-intensity endurance training led to a significant decrease in MDA concentration (P=0.001) and a significant increase in the levels of antioxidant indices (TAC, GPX, and SOD) compared to the diabetes group (P=0.001).

Moderate-intensity endurance training could reduce the oxidant index and increase antioxidant indices in the testicular tissue of diabetic rats with morphine withdrawal syndrome. This suggests a potential reduction in infertility complications in these rats.