Comparison between the Efficacy of Amitriptyline and Fluvoxamine in Treatment of Chronic Tension Type Headache
BackgroundChronic tension type headache is one of the most common types of headaches, which in half of the patients leads to decreased functional output and irregular analgesic consumption.Amitriptyline(a tricyclic antidepressant) is the most commonly used medicine in control of chronic tension type headache, but its adverse effects can cause a poor compliance in patients. With consideration of the lower side effects of the selective serotonin reuptake inhibitors such as fluvoxamine, this study compared the efficacy of fluvoxamine and amitriptyline in control of chronic tension type headache.
Methods110 eligible patients enrolled in the study and were divided into two groups: amitriptyline group (AG) and fluvoxamine group (FG).During 3 months of follow up, 81 patients completed the study, 38 patients in control(AG) and 43 ones in the case(FG) group. Self structured check lists comprised weekly headache indices (number, Intensity and duration of headache episodes), analgesic consumption and drug adverse effects. Data related to the week preceding the study, collected and regarded as basal data.Paired and independent sample T tests were used to compare the results related to each group and both groups, respectively.
ResultsHeadache indices in two groups during the first and second months of follow up improved significantly, in comparison with the basal data, in such a way that at the end of the follow up, there was no significant difference in headache indices between the two groups.
ConclusionFluvoxamine can be used in treatment of chronic tension type headache (as an alternative for amitriptyline) with equal clinical efficacy, after a month of consumption.
Journal of Medical Council of Iran, Volume:30 Issue:1, 2012
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