Association of Preeclampsia with Maternal Plasma and Umbilical Cord Lipid Concentration

Background and Preeclampsia is a pregnancy-specific condition characterized by hypertension and proteinuria. According to many predisposing factors in pathophysiology of preeclampsia, the role of lipid preoxides, is recently important. The aim of this study was to evaluate association of preeclampsia with maternal plasma and umbilical cord Lipid concentration. This case-control study was done on pregnant women referring to Babol Yahyanejad Hospital, during 2008 - 2009. Case group include 31 term preeclamptic pregnant women and for control group 31 term normal pregnant women were recruited. All women had 20-30 years old and were in gravid 1 and 2. Total TG, cholesterol, HDL and LDL for plasma and umbilical cord were measured by enzymatic and calorimetric methods. The mean level of triglyceride (291.1 102.8 VS 309.4 114.4) cholesterol (226.3 48.8 VS 234.9 40.6), LDL (119 38.3 VS 123 33.1), HDL (50.1 10.6 VS 51.5 8.1) and VLDL (59.2 20.8 VS 61.5 22.6) in women with preeclampsia and normal subjects had not significant difference (p>0.05). About level of Lipids in umblical cord, only one case in control group had abnormal Triglycerid level. The mean level of umbilical cord triglyceride (56.3 32 VS 50.1 54) umbilical cord cholesterol (70.9 22.8 VS 64.4 20.8), umbilical cord LDL (30.9 12.7 VS 26.1 10), umbilical cord HDL (28.7 10.7 VS 30.7 8.6) and umbilical cord VLDL (11.6 6.8 VS 9.9 10.7) in preeclampsia and normal groups had not significant difference (p>0.05). Result show that there was no significant association between levels of plasma and umbilical cord lipids with preeclampsia.