The effect of Satureja Khuzestanica Essential Oil (SKEO) on convulsion induced by Nicotine in male mice

Seizure is one of the most important symptoms of epilepsy and other neurological disorders. Satureja khuzestanica (SK) is an annual herb used in the traditional medicine of Iran. Because of adverse effect of synthetic medicines، nowadays medicinal plants are widely used in controlling convulsions. Convulsions investigated in mice. In this experimental study، 40 male mice were studied. Different doses (40، 80، 120 mg/kg) of the essential oil were administered in groups 1، 2، and 3 and Carvacrol (80mg/kg) was administered in group 4. In the 3% Tween (equal volume with SKEO) were injected intraperitoneally. In all groups، after 30 min، Nicotine (5 mg/kg) was injected intraperitoneally and the time for onset، duration، and intensity of the convulsion were recorded. The results showed that the SKEO and Carvacrol delaye the onset of convulsion، and decreased the duration and intensity of convulsion in 80mg/kg doses. The results of this study showed that SKEO has anti-convulsive effects. More investigations are needed in order to know the mechanisms of the extract.