The Effect of Calcium-Vitamin D in Efficacy of Induction Ovulation in Infertile Women with Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) is one of the most common hormonal problems among women in the age of fertility that causes infertility via stopping ovulation. Prescribing calcium with clomiphene may greatly impact induction ovulation and follicles growth. Thus، this study was conducted aimed on investigating the effect of Calcium-vitamin D in efficacy of induction ovulation in infertile women with PCOS.

This randomized controlled trial was conducted on 44 infertile women with PCOS in years 2010-2011. Patients were divided into two groups (22 Intervention and 22 controls) using block randomization method. Intervention group received a daily dose of 50 mg clomiphene tablet with 400 units of vitamin D3 and 1000 mg calcium and control group received a daily dose of 50 mg clomiphene tablet with placebo. In order to measure follicles size، patients underwent sonography during three menstruation cycles، each time at 13th day of menstruation. Data were analyzed using SPSS software version 11. 5 and Chi square، Fisher، Mann-Whitney and repeated measures ANOVA Tests. P less than 0. 05 was considered statistically significant.

No significant statistical different was observed in trend of changes in follicle size in two groups (p=0. 1). However، the median and mean of follicles size in intervention group was higher than control group in first، second and third months (p<0. 05). There was also no significant statistical difference between the first and second months regarding the size of follicles (p=0. 82); but the size of follicles in third month was significantly different from second month (p=0. 01).

Adding 400 units of vitamin D3 and 1000 mg calcium to normal clomiphene dosage may increase the size of follicles that its effect is especially more significant after the second post-treatment menstruation.