Investigating Choroid Plexus Volume and Capillaries Length in 15.5 Day Foetus of Diabetic Mothers Compared to Normal Foetus in Rats
Abstract:
Introduction
Diabetes mellitus is a metabolic disorder with systemic complications. Children of diabetic mothers are at risk of many disorders such as major and minor vascular injuries، retinopathy، and atherosclerosis. The present study aimed to investigate the effects of maternal diabetes on changes in choroid plexus volume and capillaries length in 15. 5 day foetus.
Methods
in this experimental study which was conducted on 30 male wistar rats، animals were divided into two groups; an experimental and a control group (n=10). Streptotosin was injected (55 mg/kg) in experimental group to induce diabetes while in control group intra-peritoneal injection of buffer citrate was done for four weeks. In the last day of the fourth week، mating was done and zero day of pregnancy was determined with vaginal plug observation. on 15th day of pregnancy، rats were anatomized and a foetus was chosen from each mother. After foetal head fixation and tissue processing، serial horizontal sections were prepared and stained with haematoxylin-eosin. Choroid plexus volume was measured by stereological techniques and the results were analysed using ANOVA statistical test.
Results
Results showed a significant difference between Choroid plexus volume and capillaries length in experimental and control groups، so that Choroid plexus volume and capillaries length were increased significantly in foetus of diabetic mothers (P<0. 05).
Conclusion
It is likely that maternal hyper-glycaemia induces a kind of angiogenesis in foetus that can cause many brain disorders.
Language:
Persian
Published:
Journal of Shaeed Sdoughi University of Medical Sciences Yazd, Volume:20 Issue:3, 2012
Pages:
306 - 314
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