Effect of Long-term Creatine Monohydrate Supplementation on Cellular Damage Indices in Non-athlete Males

Creatine monohydrate is the most common supplements used by athletes. However، there are controversies related to its positive and negative effects. This study was conducted to determine the effect of long-term creatine monohydrate supplementation on serum cellular damage in young non-athlete male. 18 non-athlete healthy male (age= 22. 88±2. 90Yr; weight=73. 58±5. 45 Kg; height= 173±6. 79Cm) were entered the study، they were subdivided into two groups، experimental (n=9) and control (n=9) groups. Each groups participated in two month of training. Experimental subjects consumed 0. 07 g/kg/day of creatinin monohydrate (crm) during training protocol، and control group received 0. 07 g/kg/day wheat flour as placebo. Venous blood samples were obtained before and 48h after last session of weight training. The results indicated that Serum LDH and CK activity mean was significantly increased after two months weight training and CrM Ingestion (LDH 90%، P=0. 004; CK 83%، P=0. 006) and placebo-training (LDH 13%، P=0. 001; CK 15%، P=0. 009). Moreover، there were significant differences between groups for CK and LDH activities mean (PCK=0. 018; PLDH=0. 001) and changes range (PCK=0. 002; PLDH=0. 005) after the protocol. This observation suggests that CrM ingestion might have adverse cellular damaging effects.