The Effect of Aerobic Exercise on Plasma Visfatin and Glycemic Control in Type 2 Diabetic Men Treated with Metformin

Visfatin is a newly discovered adipokine. Previous studies showed a direct relationship between plasma visfatin levels and type 2 diabetes mellitus (T2DM). The current study was conducted to investigate the effect of aerobic exercise on plasma visfatin in type 2 diabetic men treated with metformin. Thirty-six men with type 2 diabetes who consumed metformin (age 46/08 ± 3/08 years, BMI 30/1± 2/32 kg/m2, mean ± SD) volunteered to participate in this study. Subjects were randomly assigned in 2 groups. 18 subjects were in the aerobic exercise group (3 days per week, 35 to 50 minutes per day, 40-55% heart rate reserve) and 18 subjects in the control group. Fasting Plasma visfatin, insulin and glucose concentrations were measured before and after 8 weeks exercise in patients with T2DM and data was analyzed using Repeated Measures (ANOVA) at a Significance level of (P