Effects of hydro-alcoholic seed extract of Coriandrum sativum L. on pituitary-ovary hormones in rat

In this research, the effect of hydro-alcoholic extract seed of Coriander was studied on pituitary–ovary hormones and its possible role in infertility and reproductive activity in the immature female rats. In this experimental study, 64 immature female rats of the Wistar were divided to four groups of control, sham and experimental groups that received 150 and 300 mg/kg extract of hydro-alcoholic Coriander seeds. Half of each group was tested on day 28 and others on day 56, randomly. The extracts were orally administered. At the end of 28 and 56 days, blood samples from the heart were taken and serum hormones LH, FSH, estrogen and progesterone were measured using RIA. Data were analyzed by ANOVA and Tukey tests. Level of significance was considered at <0.05. The mean concentrations of LH and estrogen in the experimental group which received 300 mg/kg of the extract for 28 days and the experimental group which received 150 and 300 mg/kg of extracts for 56 days decreased significantly compared to control group. Concentrations of FSH in the experimental group which received 300 mg/kg of extract for 28 and 56 days decreased significantly compared to control group. Mean concentrations of progesterone in the experimental group which received 150 and 300 mg/kg of extract for 28 and 56 days showed significantly reduction compared to control group. According to the other studies, Coriander seed contains flavonoid and coumarin compounds. Probably, these components decrease gonadotropins and the enzymes involved in the steroidogenesis and reduce the secretion of estrogen and progesterone.