The Effect of Moderate Substitution of Dietary Carbohydrates by Fats on Serum Levels of Adipocytokines, Inflammatory Indices, and Biomarkers of Endothelial Function among Women with Metabolic Syndrome
Message:
Abstract:
Background And Objective

Dietary carbohydrate restriction is one of the most effective approaches in the management of metabolic syndrome. However، there is little information available on the role of inflammatory processes.

Materials And Methods

In a randomized cross-over clinical trial، thirty overweight or obese (BMI>25 kg/m2) women with metabolic syndrome were randomly allocated into two groups، to follow either a high-carbohydrate (HC) (60-65% carbohydrates، 20-25% fats) or a moderately-restricted carbohydrate (MRC) (43-47% carbohydrate، 36-40% fats) diet for 6 weeks. After a 2-week washout period، individuals were switched to the alternate diet for an additional 6 week period. At the beginning and the bend of each period، markers of inflammation (hs-CRP، hs IL-6، hs TNF-α and SAA)، endothelial function (E-selectin، sICAM-1 and sVCAM-1)، and adipocytokines (leptin and adiponectin) were measured in both study groups at baselines (i. e.، fasting state).

Results

Consumption of the HC diet was associated with increased levels of SAA (3. 27 ±1. 22 μg/ml)، while consumption of MRC diet did not result in such unfavorable effects (P=0. 04). Serum concentrations of leptin and adiponectin were reduced by the HC diet (P<0. 02)، but these changes were not significant between the two diets (P>0. 05). Serum concentrations of hs-CRP، hs TNF-α and IL-6 were not influenced by either diet. There were also no significant differences observed between the two diets in terms of their effects on serum sICAM-1، sVCAM-1، and E-selectin concentrations.

Conclusion

Short-term substitution of dietary carbohydrates by unsaturated fats seems to have no significant effects on serum levels of adipocytokines، biomarkers of inflammation، and endothelial function except for SAA.

Language:
Persian
Published:
Journal of Advances in Medical and Biomedical Research, Volume:20 Issue: 83, 2013
Pages:
1 to 16
magiran.com/p1076525  
دانلود و مطالعه متن این مقاله با یکی از روشهای زیر امکان پذیر است:
اشتراک شخصی
با عضویت و پرداخت آنلاین حق اشتراک یک‌ساله به مبلغ 990,000ريال می‌توانید 70 عنوان مطلب دانلود کنید!
اشتراک سازمانی
به کتابخانه دانشگاه یا محل کار خود پیشنهاد کنید تا اشتراک سازمانی این پایگاه را برای دسترسی نامحدود همه کاربران به متن مطالب تهیه نمایند!
توجه!
  • حق عضویت دریافتی صرف حمایت از نشریات عضو و نگهداری، تکمیل و توسعه مگیران می‌شود.
  • پرداخت حق اشتراک و دانلود مقالات اجازه بازنشر آن در سایر رسانه‌های چاپی و دیجیتال را به کاربر نمی‌دهد.
دسترسی سراسری کاربران دانشگاه پیام نور!
اعضای هیئت علمی و دانشجویان دانشگاه پیام نور در سراسر کشور، در صورت ثبت نام با ایمیل دانشگاهی، تا پایان فروردین ماه 1403 به مقالات سایت دسترسی خواهند داشت!
In order to view content subscription is required

Personal subscription
Subscribe magiran.com for 50 € euros via PayPal and download 70 articles during a year.
Organization subscription
Please contact us to subscribe your university or library for unlimited access!