Relationship between biochemical risk factors for Atherosclerosis in dialysis patient and healthy persons

One of the major causes of morbidity and mortality in dialysis patient is cardiovascular disease.The prevalence of cardiovascular diseases is estimated to be between 10 to 30 times higher than general population. Some of the known risk factors for calcification are hypetcalcemia and hyperphosphatemia, increased parathyroid hormone(iPTH), increased CRP and dyslipidemia. We selected 30 dialysis patients and 30 healthy persons among persons admitted to the Imam Ali’s hospital of Bojnurd. 5 ml blood was obtained from all subjects. Parathyroid hormone(iPTH) and hs-CRP were measured with ELISA (Enzyme-Linked Immuno Sorbent Assay) reader. Other biochemical factors were measured with autoanalyser. it was found that Parathyroid hormone (iPTH), mean LDL, calcium-phosphorus products and hs-CRP, between patient group and control group, were significantly different (p<0.001). We also found significant direct relationship between the disease and increased risk factors for vascular calcification. These results support a role for serum iPTH, hs-CRP, ca*P ratio and LDL level as risk factors for cardiovascular disease in hemodialysis patients.