ASSOCIATION OF SERUM ANTIBODIES BETWEEN SINGLE AND DOUBLE MMR VACCINATION IN CHILDREN UNDER THREE YEARS OLD REFERRED TO PEDIATRIC WARD OF KERMAN AFZALIPOUR HOSPITAL

Measles، rubella and mumps vaccination prevented the viral diseases threatening children during the recent decades. The incidences of these diseases in countries with high vaccination coverage have reduced significantly. Initial vaccination was as a single dose and then two dose vaccination was introduced. This change in the vaccination schedule still is renewed but the level of immunity، protection، production and stability of antibodies in the body is unknown. The aim of this study was the comparison of antibody levels among the children who received single or double doses of MMR vaccination. In this study، 200 children were classified as 100 patients with single dose vaccination (at age 12 months) and 100 with a double vaccination (at age 18 months). There was no relation between the serum level of antibody and gender of children. The positive serum level of IgM antibody against measles in single and double vaccination groups was 33% and 39% respectively with no significant difference. The positive serum level of IgG antibody against measles in single and double vaccination groups was 76% and 99% respectively with significant difference. The positive serum level of IgM antibody against mumps in single and double vaccination groups was 84% and 99% respectively with significant difference. The positive serum level of IgG antibody against mumps in single and double vaccination groups was 97% and 99% respectively with no significant difference. The positive serum level of IgM antibody against rubella in single and double vaccination groups was 21% and 14% respectively with no significant difference. The positive serum level of IgG antibody against rubella in single and double vaccination groups was 84% and 97% respectively with significant difference. The quantitative amounts of IgM and IgG against three diseases measles، mumps and rubella in children with second vaccination were more than once administration significantly. Finally، two time vaccination schedule in 12 and 18 months of age can immunize better than other vaccination programs and is more effective.