Relationship between XPD Lys 751 Gln polymorphism and colorectal cancer risk: a case-control study in a population-based study

This study has examined the relationship between the XPD Lys 751 Gln polymorphism and colorectal cancer in 88 patients and their 88 age and sex-matched controls. Genomic DNA from peripheral whole blood was extracted using standard method to determine the genotype of subjects with RFLP-PCR analysis. Although this study shows cancer patients harbor more heterozygous genotype (XPD Lys 751 Gln) (OR=1.33, CI: 0.679-2.620 and less wild genotype (Lys751 Lys) compare to control group. However, it is not statistically significant (P = 0.406). Furthermore, colorectal cancer was less common in individuals with recessive homozygous genotype (OR=0.097, CI: 0.032-0.297; P= 00.000). Notably, in our study colorectal cancer was more frequent in male gender, elder people compared younger people and individuals with positive colorectal cancer in their first relatives (OR=4.5; CI= 2.010-10.044, P=0.000).